Effect of Oral <I>Lactobacillus salivarius </I>TI2711 (LS1)Administration on Periodontopathic Bacteria in Subgingival Plaque.

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

“…It was demonstrated in patients, who suffered from periodontitis or gingivitis, that probiotic bacteria accumulated in microbial biofilms thus replacing or reducing pathogenic bacteria (Grudianov et al, 2002;Tsubura et al, 2009). Ishikawa et al (2003), and Matsuoka et al (2006) demonstrated that the oral application of probiotic pills containing L. salivarius significantly reduced the concentration of the periopathogenic bacterium P. gingivalis in saliva and subgingival plaque in healthy volunteers. Shimauchi et al (2008) documented a reduced concentration of periodontopathogenic bacteria after the administration of probiotic Lactobacilli over a period of 8 weeks, which was associated with improved periodontal conditions.…”

“…Several clinical studies demonstrated that a regular consumption of probiotic lactobacilli and Bifidobacterium decreased the number of cariogenic streptococci in saliva and dental plaque, resulting in a significant lower risk of caries (Näse et al, 2001;Ahola et al, 2002;Ç aglar et al, 2006;Ç aglar et al, 2007;Cildir et al, 2009). Several studies also revealed that probiotic Lactobacillus strains were reducing gingival inflammation (Krasse et al, 2006;Twetman et al, 2009), improving periodontal health (Shimauchi et al, 2008) and decreasing the concentration of black-pigmented rods including Porphyromonas gingivalis in saliva and subgingival plaque (Ishikawa et al, 2003;Matsuoka et al, 2006). In contrast, Staab et al (2009) found no changes of clinical inflammatory parameters.…”

Microbiota, cirrhosis, and the emerging oral-gut-liver axis

“…In an RCT, Krasse and colleagues found that administration of probiotics twice daily for 2 weeks significantly reduced gingivitis (101). Matsuoka and colleagues noted a significant reduction in total plaque bacteria and Porphyromonas gingivalis after administration of Lactobacillus salivarius; however, bacterial levels returned to baseline after the treatment was stopped (102). Similarly, Teughels and colleagues found that probiotic treatment in patients with chronic periodontitis reduced plaque score, bleeding, gingival scores, and markers of inflammation during the period of probiotic administration (65).…”

Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double‐blind, placebo‐controlled study

“…In the previous reports, consumption of products containing probiotic lactobacilli was shown to successfully reduce caries risk and the number of mutans streptococci in the oral cavity (Näse et al 2001, Ahola et al 2002, Çaglar et al 2006). A few studies also revealed that probiotic Lactobacillus strains were useful in reducing gingival inflammation and the number of black‐pigmented rods including Porphyromonas gingivalis in the saliva and subgingival plaque (Ishikawa et al 2003, Krasse et al 2006, Matsuoka et al 2006). However, little is known about the effects of probiotics on periodontal health and the microbiota of supra‐ and subgingival plaque.…”