Improvement of periodontal condition by probiotics with <i>Lactobacillus salivarius</i> WB21: a randomized, double‐blind, placebo‐controlled study

Shimauchi, Hidetoshi; Mayanagi, Gen; Nakaya, Seigo; Minamibuchi, Maiko; Ito, Yasuhiro; Yamaki, Kouya; Hirata, Haruhisa

doi:10.1111/j.1600-051x.2008.01306.x

Cited by 223 publications

(242 citation statements)

References 43 publications

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“…Ishikawa et al (2003), and Matsuoka et al (2006) demonstrated that the oral application of probiotic pills containing L. salivarius significantly reduced the concentration of the periopathogenic bacterium P. gingivalis in saliva and subgingival plaque in healthy volunteers. Shimauchi et al (2008) documented a reduced concentration of periodontopathogenic bacteria after the administration of probiotic Lactobacilli over a period of 8 weeks, which was associated with improved periodontal conditions. Although the characterization of the oral microflora was not the aim of this study, it may be speculated that the accumulation of a non-pathogenic bacterial biofilm on the tooth surfaces was very likely causative for the reduced inflammation in the test group.…”

Section: Discussionmentioning

confidence: 96%

“…Several clinical studies demonstrated that a regular consumption of probiotic lactobacilli and Bifidobacterium decreased the number of cariogenic streptococci in saliva and dental plaque, resulting in a significant lower risk of caries (Näse et al, 2001;Ahola et al, 2002;Ç aglar et al, 2006;Ç aglar et al, 2007;Cildir et al, 2009). Several studies also revealed that probiotic Lactobacillus strains were reducing gingival inflammation (Krasse et al, 2006;Twetman et al, 2009), improving periodontal health (Shimauchi et al, 2008) and decreasing the concentration of black-pigmented rods including Porphyromonas gingivalis in saliva and subgingival plaque (Ishikawa et al, 2003;Matsuoka et al, 2006). In contrast, Staab et al (2009) found no changes of clinical inflammatory parameters.…”

Section: Introductionmentioning

confidence: 99%

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Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

et al. 2011

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Objectives: To determine the effects of a probiotic milk drink consumed over a period of 28 days, regarding the expression of clinical inflammatory parameters of the oral gingiva during various phases of plaque-induced gingivitis. Methods: Twenty-eight adults with healthy gingiva took part in a prospective and clinical-controlled study. The test group was advised to consume a probiotic milk drink (Yacult) daily during a period of 4 weeks; the control group did not receive any probiotic food or drink. After 2 weeks of consumption of the probiotic drink, participants were advised not to brush their teeth for 14 days. Subsequently, at baseline as well as on days 1, 3, 5, 7 and 14, the following clinical parameters were assessed: plaque index (PI), gingival index (GI), gingival crevicular fluid (GCF) volume and bleeding on probing (BOP). Results: At baseline, the PI was significantly higher in the test group compared with controls (0.44±0.50 vs 0.09±0.24 PI; P ¼ 0.0001). The termination of oral hygiene increased clinical inflammatory parameters in both groups. At day 14, the parameters PI, GI, GCF volume and BOP were significantly higher compared with baseline values (P ¼ 0.0001). At day 14, BOP levels (18.75 ± 12.32 vs 36.88 ± 12.54%) and GCF volume (18.78 ± 16.7 vs 35.72 ± 16.1 Periotron units) were significantly lower in the test group compared with the control group (P ¼ 0.005). Conclusion:The results of our study indicate that a daily consumption of a probiotic milk drink reduces the effects of plaqueinduced gingival inflammation associated with a higher plaque score due to the high-carbohydrate content of the probiotic milk beverage.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

et al. 2011

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“…By using a probiotic treatment (L. reuteri) also clinical effects were found, like a significant reduction in the gingival index and plaque scores [56]. Smokers showed a significantly greater improvement in plaque scores in a clinical trial using freeze-dried probiotic tablets of L. salivarius [57]. Even heat-killed L. plantarum decreased the depth of periodontal pockets in a randomised, doubleblind, placebo-controlled clinical trial [58].…”

Section: Periodontal Diseasementioning

confidence: 99%

Lactobacilli for the Treatment of Oral Diseases

Hoffmann¹,

Daniels²

2017

J Prob Health

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Probiotics are defined as live microorganisms that beneficially affect the host. Probiotic bacteria have been used therapeutically for years to target gastrointestinal disease by rebalancing the complex microflora. Besides the gastrointestinal tract also the oral cavity is highly colonized by bacteria and many different bacterial species are part of the microbiota in the mouth, as it offers ideal conditions for bacteria with a stable temperature, moist surface with a relatively stable pH and regular supply of nutrients. By disturbing the balance of microorganisms in the oral cavity or by extensive accumulation of plaque, the ratio of pathogenic organisms can increase and lead to oral health problems. Probiotic bacteria, like lactobacilli, are a promising treatment strategy for oral diseases with a microbiological aetiology. Those include plaqueassociated diseases like dental caries, which is an infectious disease with microbial processes eroding and destroying the hard dental tissue or inflammation of periodontal tissue, namely gingivitis and the more severe periodontitis. Moreover, endodontic infections, and even fungal, viral and acute bacterial infections could be treated by a probiotic therapy. The interest of probiotics in the field of oral health is growing, although it is still in its infancy. The present review adresses criteria for the selection of probiotic lactobacilli strains. It encompasses existing evidence on the use of lactobacilli for caries, halitosis and candidiasis, as well as for periodontal disease like Gingivitis and periodontitis.

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“…10 The most commonly used and studied probiotic are lactic acid bacteria, in particular Lactobacillus spp., and Bifidobacterium spp. 26 To determine the effects of probiotic on oral health promotion, we conducted a double blind, placebo-controlled randomized clinical trial in healthy subjects with gingivitis. The specific aim of this study was to investigate the effect of combined probiotic formulation on plaque, gingivitis and caries during and after discontinuation of administration.…”

Section: Journal Of Research and Practice Inmentioning

confidence: 99%

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Dhawan¹,

Dhawan²

2013

DENT

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The aim of this study was to investigate commercially available combined probiotic formulation for its effect on plaque, gingivitis and salivary Streptococcus mutans levels in subjects with chronic gingivitis. A total of 36 subjects were finally enrolled in a double blind placebo controlled randomized trial. Selected subjects were randomly divided in two groups; Group A (Control group) with 17 subjects, receiving placebo tablets twice daily and Group B (Probiotic group) with 19 subjects receiving probiotic tablets twice daily. The study consisted of two 2 weeks periods, a two week intervention period (T1-T2) and a two week post treatment period (T2-T3). Clinical parameters and bacterial counts of salivary Streptococcus mutans, were evaluated at the baseline (T1), at the completion (T2) of medication and 2 weeks after medication (T3). On comparative evaluation between the two groups, results indicated that Group-B (Probiotic group) exhibited statistically significant reduction in Plaque Index, Gingival index and Streptococcus mutans level than Group-A (Control group) over the entire span of the study. Our results indicated that probiotic could be useful in the improvement/ maintainance of oral health.

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Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double‐blind, placebo‐controlled study

Abstract: Our results indicate that probiotics could be useful in the improvement/maintenance of oral health in subjects at a high risk of periodontal disease.

Cited by 223 publications

References 43 publications

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

Lactobacilli for the Treatment of Oral Diseases

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

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