Effect of Oral Supplementation for Rabbits of Pomegranate seed Extract on Some Serum Biochemical Parameters in Relation to oral Inflammation, oxidative stress, and wound healing

Omer, Rezan Majeed; Baban, Dilyar Ahmed; Ahmed, Bakhtiar M

doi:10.26477/jbcd.v31i2.2618

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in agreement with the results of the Florence et al (2017) study [21]. In another research on treatment by oral supplementation of pomegranate peel extract in a mandibular bone defect in a rabbit, on day 7 post-surgery, the level of calcium decreased [22]. A previous study has reported that the level of blood calcium increases following an increment in the dosage of the Arjuna Terminalia extract, and repair occurs more rapidly in the group with a higher dose of extract.…”

Section: Discussionsupporting

confidence: 91%

“…Several previous studies have investigated the bone healing process using biochemical markers of the bone formation such as calcium, phosphorus, and alkaline phosphatase [6,[21][22][23][24]. High levels of calcium and phosphorus in the blood and extracellular fluids trigger the deposition of calcium phosphate crystals in the osteoid and make it harder [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit

et al. 2021

View full text Add to dashboard Cite

Background Bone fractures are medical emergencies that require prompt intervention to help return bone to its normal function. Various methods and treatments have been utilized to increase the speed and efficiency of bone repair. This study aimed to investigate the treatment effects of Prunus dulcis aqueous extract on tibial bone healing in rabbits. Methods All animals were distributed in five groups with six rats in each group, including the sham group, the control group in which tibial lesion was made and received distilled water, treatment groups with 150 mg kg−1, 300 mg kg−1 doses of Prunus dulcis extract, and osteocare treated group. Biochemical blood factors including calcium, phosphorus, and alkaline phosphatase (on days 0, 10, 30, and 50), biomarkers of oxidative stress such as GPx, CAT, and MDA (on days 10 and 30), radiological evaluation, histopathological parameters, and osteocalcin immunohistochemical expression were assessed. Results The data showed calcium levels in the treatment groups increased significantly from day 10 to day 50, respectively, and blood phosphorus levels decreased from day 10 to day 50 in the treatment groups. Alkaline phosphatase initially increased and then decreased in treatment groups. In the treatment groups, GPx and CAT levels significantly increased, and the serum amount of MDA reduced. The best antioxidant results were related to the extract-treated group with a higher dose. Radiographic score was significantly higher in the treatment groups than the control group on day 30. Based on the pathological findings, the healing occurred faster in the extract-treated group with a higher dose. Osteocalcin expression was significantly higher in the control group than that in the treatment groups. Conclusions Treatment with Prunus dulcis extract with a dosage of 300 mg/kg accelerated tibial bone healing in rabbits. Graphical abstract

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Bw for 21 days [19]. Pomegranate seeds extract tablets were supplied to groups III and IV on day one following the administration of AFB1 at 100 mg/Kg [20].…”

Section: Experimental Protocolmentioning

confidence: 99%

Protective Role of Pomegranate Seed Extract to Reduce Aflatoxin B1 Toxicity in Rabbits

Hamed¹,

Osama

Zohree³

et al. 2023

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

H IS investigation aimed to assess how Pomegranate Seed Extract (PSE) counteracted the negative impacts of Aflatoxin B1 Residue (AFB1) on liver health and antioxidant status in Aflatoxicated Rabbits. Twenty healthy male New Zealand rabbits (aged six weeks) were randomly divided into four experimental groups. Group I served as the negative control group without any treatment. Groups II and III were given AFB1 orally at (30 µg/kg.BW/day) for 21 days. On day one after Aflatoxin B1 administration, groups 3 and 4 were given 100 mg/kg of Pomegranate seed extract (PSE). The results showed that rabbits in groups 3 and 4 given 100 mg/Kg of PSE. Decreased levels of (ALT, AST, cholesterol, triglyceride, and total bilirubin), were observed in Group III which were significantly higher in the treated group II, indicating that PSE supplementation improved liver function tests. In addition, PSE supplementation significantly reduced Malondialdehyde (MDA) levels. Simultaneously, compared to the Aflatoxicated group, there has been a considerable rise in (superoxide dismutase enzyme (SOD), catalase (CAT), glutathione peroxidase (GPX), and reduced glutathione (GSH)) enzymes. According to the findings, Pomegranate seed extract improved treated rabbits' liver function tests and antioxidant status through eliminating the detrimental effects of oxidative stress produced by Aflatoxin B1.

show abstract

Effect of Oral Supplementation for Rabbits of Pomegranate seed Extract on Some Serum Biochemical Parameters in Relation to oral Inflammation, oxidative stress, and wound healing

Cited by 2 publications

References 0 publications

The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit

The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit

Protective Role of Pomegranate Seed Extract to Reduce Aflatoxin B1 Toxicity in Rabbits

Contact Info

Product

Resources

About