Effect of orlistat on serum uric acid level in adults: A systematic review and meta‐analysis of randomised controlled trials

Noori, Soheila; Mirzababaei, Atieh; Amini, Mohammad Reza; Clark, Cain C. T.; Mirzaei, Khadijeh

doi:10.1111/ijcp.14674

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…To further illustrate that the relationship between diet and hyperuricemia is largely mediated by obesity, we performed reduced rank regression and obtained one main pattern associated with obesity, “High fat and low vitamin” diet, which had a significant promoting effect on hyperuricemia, and the effect was entirely caused by weight gain. In fact, a variety of studies show that greater BMI is associated with an increased risk of hyperuricemia and that weight loss is an important measure for the prevention and management of hyperuricemia and gout [ 46 , 49 , 50 ]. For example, a cohort study including 1189 patients observed over 6.45 years showed that obesity (BMI > 27) was an independent risk factor for incident gout among women with and without hyperuricaemia [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, a cohort study including 1189 patients observed over 6.45 years showed that obesity (BMI > 27) was an independent risk factor for incident gout among women with and without hyperuricaemia [ 51 ]. Furthermore, Mendelian randomization studies have found that obesity is causally associated with serum urate levels in the general population [ 52 ], a systematic review of randomized controlled trials found a significant reduction in serum uric acid levels following orlistat therapy in adults [ 50 ]. In addition, a meta-analysis including 20 cohort studies assessed the relationship of bariatric surgery with gout and serum urate, and the results showed that uric acid decreased by an average of 0.73 mg/dL 3 months after bariatric surgery and 1.91 mg/dL 3 years after surgery [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

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Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

et al. 2022

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Background Diet has long been hypothesized to play an important role in hyperuricemia, and weight gain is a factor that is strongly associated with the rise in serum urate. We aimed to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and to determine whether a weight-loss diet is an effective way to prevent hyperuricemia. Methods This cross-sectional study analysed representative samples of United States (n = 20,081; NHANES 2007–2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyse the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine whether four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product index (LAP), mediated the relationship between nutrient patterns and hyperuricemia. Results PCA revealed three nutrient patterns (including “Low energy diet”, “Lower vitamin A, C, K pattern” and “Vitamin B group”), and only Vitamin B group had a total effect on hyperuricemia. RRR revealed one main nutrient pattern associated with obesity, which was characterized by High fat and low vitamin levels and was significantly associated with hyperuricemia. Mediation analysis showed that obesity mostly or even completely mediated the relationship between nutrient patterns and hyperuricemia, especially traditional obesity indicators, which played a key intermediary effect. The proportions of indirect effects for BMI and WC were as high as 53.34 and 59.69, respectively. Conclusions Our findings suggest that the direct effect of diet on hyperuricemia is weak, and obesity plays a critical mediating role in the relationship between diet and hyperuricemia, which confirms that a weight-loss diet such as a “Low fat and high vitamin diet” may be useful in preventing hyperuricemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

et al. 2022

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“…The delay in increasing the concentration of orlistat in plasma indicates the effectiveness of the properties of the modified release of the MR-OA composition [ 37 ]. A separate area of research is now the analysis of the effect of orlistat on uric acid in blood serum in adults [ 38 ].…”

Section: Novel Drugs In Obesity Treatmentmentioning

confidence: 99%

Pharmacological Treatments and Natural Biocompounds in Weight Management

et al. 2023

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The obesity pandemic is one of society’s most urgent public health concerns. One-third of the global adult population may fall under obese or overweight by 2025, suggesting a rising demand for medical care and an exorbitant cost of healthcare expenditure in the coming years. Generally, the treatment strategy for obese patients is largely patient-centric and needs dietary, behavioral, pharmacological, and sometimes even surgical interventions. Given that obesity cases are rising in adults and children and lifestyle modifications have failed to produce the desired results, the need for medical therapy adjunct to lifestyle modifications is vital for better managing obesity. Most existing or past drugs for obesity treatment target satiety or monoamine pathways and induce a feeling of fullness in patients, while drugs such as orlistat are targeted against intestinal lipases. However, many medications targeted against neurotransmitters showed adverse events in patients, thus being withdrawn from the market. Alternatively, the combination of some drugs has been successfully tested in obesity management. However, the demand for novel, safer, and more efficacious pharmaceutical medicines for weight management does exist. The present review elucidates the current understanding of the available anti-obesity medicines of synthetic and natural origin, their main mechanisms of action, and the shortcomings associated with current weight management drugs.

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“…additionally, the use of clinical medications in these conditions can interfere with ua concentrations. examples of these medications include calcium channel blockers (e.g., amlodipine and cilnidipine) (207), angiotensin-converting enzyme inhibitors (e.g., captopril, enalapril and ramipril) (208,209), angiotensin-converting enzyme ii receptor antagonists (e.g., losartan) (210), lipid-lowering agents (e.g., atorvastatin, simvastatin, ezetimibe and fenofibrate) (211), weight loss medications (e.g., orlistat) (212) and hypoglycemic agents (e.g., metformin) (213). additionally, sodium glucose transporter protein 2 reduces ua concentrations (214,215).…”

Section: Potential Mechanisms By Which Ph Affects Ua Concentrationsmentioning

confidence: 99%

Insights into the relationship between serum uric acid and pulmonary hypertension (Review)

Zhou,

Chen,

Zheng

et al. 2023

Mol Med Rep

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Pulmonary hypertension (PH) is a progressive lethal disease, which is characterized by abnormal vascular remodeling and persistently elevated pulmonary artery pressure, eventually leading to right heart failure and even death. although great progress has been made in treating PH, the mortality rate remains high. Metabolic disorders are one of the important hallmarks of PH. obesity, lipids, glucose tolerance and insulin resistance are risk factors for numerous cardiovascular diseases and are often accompanied by a considerable increase in serum uric acid (Sua) concentrations. uric acid (ua) is the end product of purine nucleotide metabolism and is closely related to cardiovascular diseases including PH. Hyperuricemia promotes the development and progression of PH through endothelial dysfunction, oxidative stress, inflammatory responses and activation of the renin-angiotensin system. in the present review, the advancements in knowledge about ua metabolism and PH, and the current understanding of the potential interactions and mechanisms of Sua in PH were systematically summarized, which may provide new insights into the pathogenesis of PH.

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Effect of orlistat on serum uric acid level in adults: A systematic review and meta‐analysis of randomised controlled trials

Cited by 4 publications

References 31 publications

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Pharmacological Treatments and Natural Biocompounds in Weight Management

Insights into the relationship between serum uric acid and pulmonary hypertension (Review)

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