Effect of ovarian steroids on vascular endothelial growth factor a expression in bovine uterine endothelial cells during adenomyosis

Łupicka, M.; Zadroga, Anna; Szczepańska, Alicja; Korzekwa, Anna

doi:10.1186/s12917-019-2222-0

Cited by 8 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the endometrium of endometriosis patients might be hyper-responsive to estrogen stimulation and thus enhance the expression of VEGF. In addition, the dysregulation of VEGFRs (downregulation of VEGFR-1 and upregulation of VEGFR-2) seems to be responsible for endometriosis [ 114 ]. Kim et al have shown that expression of VEGFR-1, VEGFR-2, and VEGFR-3 was higher in the mid-luteal endometrium of patients with endometriosis [ 115 ].…”

Section: Vegf In Reproductive Failurementioning

confidence: 99%

Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Guo

et al. 2021

Biomolecules

View full text Add to dashboard Cite

Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.

show abstract

Section: Vegf In Reproductive Failurementioning

confidence: 99%

Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Guo

et al. 2021

Biomolecules

View full text Add to dashboard Cite

show abstract

“…The rabbit ovary and uterus undergo substantial transformation following ovulation [ 4 ]. The endometrium undergoes morphological and physiological cyclic changes, including proliferation, differentiation, apoptosis, and regeneration [ 11 , 12 ]. Therefore, angiogenesis, which is the development of new vasculature from preexistent vessels, plays a fundamental role in tissue remodeling and is necessary for implantation and normal pregnancy and proper uterine blood supply maintenance [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…During the reproductive cycle, both estrogen and progesterone hormones play a crucial role in controlling the uterine cyclic changes and functions of their receptors. Furthermore, these hormones influence the uterine vasculature growth either directly through their receptors or indirectly by initiating proangiogenic factor release, including vascular endothelial growth factor (VEGF) [12,15]. VEGF is one of the most common angiogenic factors that stimulate robust angiogenesis, increases blood vessel permeability, and plays a crucial role in ovarian folliculogensis and consequently CL formation and maintenance [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Ovarian, uterine, and luteal vascular perfusions during follicular and luteal phases in the adult cyclic female rabbits with special orientation to their histological detection of hormone receptor

et al. 2022

View full text Add to dashboard Cite

Understanding the does reproductive hemodynamic changes during the estrous cycle is crucial for improving reproductive competence and fertility potential in this species. The objective of this study is to investigate the hemodynamic variations in ovarian (OA) and uterine (UA) arteries, histological and morphometric changes in ovarian and uterine tissues throughout the follicular (FP) and luteal (LP) phases in rabbits and determine estrogen (ER), progesterone (PR) receptors, and vascular endothelial growth factor (VEGF) distributions using immunohistochemistry.Fourteen adults pluriparous New Zealand rabbits were divided into rabbits at the FP (Day − 1; n = 7) and those at the LP (Day 9; n = 7). Animals were subjected to Doppler, hormonal (estrogen [E2], progesterone [P4], insulin-like growth factor [ILGF], and VEGF), histological, and immunohistochemical analyses. In LP, OA Doppler indices were significantly increased, whereas peak systolic velocity (PSV) was decreased compared with that in FP. UA Doppler indices were significantly decreased in the LP, whereas PSV was increased (P < 0.05). E2 levels were increased in the FP, whereas P4 levels were increased in the LP. The morphometric analysis of uterine tissues during the LP revealed an increase in the mean uterine endometrium length, endometrial connective tissue area percentage (%), endometrial glands number, myometrial area (%) and thickness. Furthermore, ovarian follicles and corpus luteum (CL) displayed strong positive immunoreactivity for ER, PR, and VEGF-A during both phases. The ovarian sections displayed a substantial (P < 0.05) increase in the area % of VEGF-A in the ovarian follicles during FP while in the CL during LP. Conversely, area percentage of VEGF-A immunoreactivity in the uterine luminal and glandular epithelia during the FP and LP revealed no differences. However, the number of VEGF-A–stained blood capillaries revealed an increase during LP than FP. In conclusion, this study demonstrated for the first time the changes in both ovarian and uterine arteries during two different phases of the rabbit cycle in relation to the histo-morphometric analysis and distribution of ER, PR, and VEGF-A, which regulate uterine functions that play a role in reproduction.

show abstract

“…Нині інформація про внутрішньоутробний розвиток сечостатевої системи визначається теорією Мюллера, визнаною більшістю дослідників [14,21,33,36,40].…”

Section: результати обговоренняunclassified

Modern view on the germ and embryogenesis of the urinary organs

Bulyk¹,

Popeliuk²,

Melnyk³

et al. 2022

Rep. of Vinnytsia Nation. Med. Univ.

View full text Add to dashboard Cite

Annotation. The literature is devoted to the analysis of scientific literature for the last 10 years from the electronic databases "PubMed" and "National Library of Ukraine named after V. I. Vernadsky", which are devoted to the study of the formation and development of organs and structures of the urinary system. The consequences of perinatal morphogenesis play the most essential role in the causes and contribution to many congenital malformations (CM), stillbirths, and infant morbidity. According to the Medical and Genetic Service of the Ministry of Health of Ukraine, up to 3,000 cases of CM of various organs and systems are recorded annually among newborns in Ukraine. CM of the genitourinary system ranks 3rd in frequency, among which CM of the female genitalia is up to 6 %. These figures are somewhat subjective, as a certain percentage of pathology of the female reproductive system is detected only when a girl reaches childbearing age, which greatly complicates the choice of methods and effectiveness of treatment. The rapid development of the genitourinary system of the fetus requires morphologists to comprehensively study the patterns of morphogenesis and the development of topographic and anatomical relationships of the reproductive system and urinary tract in the early period of human ontogenesis. The problem of combining information about the structural organization of the urinary tract and genital system into a consolidated morphofunctional unit is one of the cardinal problems of perinatal urology. The final formation of the urogenital organs is as follows. The initial kidneys' replacement with the permanent ones, metanephros, begins to form, from the same nephrogenic cord that gave rise to the primary kidney. The proper permanent renal parenchyma develops from the nephrogenic cord (renal tubuli). From the 3rd month, the permanent kidneys replace the mesonephros as the excretory organs already function. Thus, the embryonic development of the genitals is closely related to the development of the urinary tract and kidneys. Therefore, the CM of these two systems often occurs together. Active introduction of perinatal prophylaxis of urogenital organs requires modern approaches and methods of examination of intrauterine life. Therefore, the complex of embryotopographic studies attains special significance, having combined the consideration of organically critical periods of development with the understanding of the peculiarities of the spatial relationships of organs and structures of the genitourinary system.

show abstract

Effect of ovarian steroids on vascular endothelial growth factor a expression in bovine uterine endothelial cells during adenomyosis

Cited by 8 publications

References 48 publications

Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Ovarian, uterine, and luteal vascular perfusions during follicular and luteal phases in the adult cyclic female rabbits with special orientation to their histological detection of hormone receptor

Modern view on the germ and embryogenesis of the urinary organs

Contact Info

Product

Resources

About