Effect of overweight/obesity on response to periodontal treatment: systematic review and a meta‐analysis

Papageorgiou, Spyridon N.; Reichert, Christoph; Jäger, Andreas; Deschner, James

doi:10.1111/jcpe.12365

Cited by 58 publications

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“…Metaanalyses evaluating this question reported that periodontal treatment effects on oral health outcomes did not differ among obese and non‐obese groups 24 , 25 . However, periodontal treatment had a greater beneficial effect on inflammatory markers and glycemic profile in patients with diabetes and obesity compared with those with diabetes and without obesity, even when there was no effect on oral health outcomes 25 . These findings suggest that obesity may modify the effect of periodontal treatment on systemic inflammation.…”

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confidence: 99%

“…The effect of obesity on periodontal treatment outcomes has not been studied extensively 24–26 . Metaanalyses evaluating this question reported that periodontal treatment effects on oral health outcomes did not differ among obese and non‐obese groups 24 , 25 . However, periodontal treatment had a greater beneficial effect on inflammatory markers and glycemic profile in patients with diabetes and obesity compared with those with diabetes and without obesity, even when there was no effect on oral health outcomes 25 .…”

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Commentary: Periodontal Treatment and Inflammation in Diabetes: Association or Causation?

Merchant

Josey

2016

Journal of Periodontology

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Commentary: Periodontal Treatment and Inflammation in Diabetes: Association or Causation?

Merchant

Josey

2016

Journal of Periodontology

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“…In addition, those individuals present a higher risk of chronic periodontitis 10 , 22 inducing variations among metabolic and inflammatory markers, when compared to normal-weight individuals 16 . Nevertheless, obese teenagers reported having contributed less when submitted to long orthodontic treatments with fixed appliances 14 …”

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Obesity and orthodontic treatment: is there any direct relationship?

Consolaro

2017

Dental Press J. Orthod.

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Obesity is a wide-spread condition directly or indirectly connected with an increase in the prevalence of a variety of human diseases. It affects over 50% of the western overall population. In 2017, a thorough analysis of 204 studies on obesity and cancer revealed that the condition increases the risk of the following types of cancer: stomach, colon, rectal, bile duct, pancreatic, esophagus, breast, endometrial, ovarian, kidney and multiple myeloma. The first study aiming at establishing a connection between obesity and the rate of induced orthodontic tooth movement was conducted by Saloom et al; however, it could not effectively nor significantly reveal any direct influence or effect. Despite being identified during the first week, differences could not be explained and treatment time remained unchanged. In spite of lack of studies in the literature on the connection between obesity and the rate of induced tooth movement, in clinical practice, courses or specialized training, we should not have protocols changed nor adopt any measures or expect significant differences between normal-weight and obese individuals. It should be emphasized that unsuccessful cases or cases of root resorption associated with treatment should not be assigned to obesity, since scientific data is insufficient to do so.

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“…The accumulation of fat was reported to lead to low-grade systemic inflammation (4). Besides, obesity and related fat accumulation might be responsible for the release of local and systemic proinflammatory cytokines and adipocytokines (including leptin, adiponectin and resistin) from adipocytes, resulting in modifications of the host response-, and playing a role in periodontal hard-and soft-tissue destruction (8)(9)(10). The studies have shown the causal relationship between the cytokines and tissue destruction (11).…”

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Deneysel periodontitiste fazla kilolu olma durumunun dolaşımdaki sitokinler ve adipokinler üzerine etkisi

2017

SDÜ Sağlık Bilimleri Dergisi

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Objective: Interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF-α) are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats. Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats (NH, n = 8), normal weight rats with periodontitis (NP, n = 8), overweight, periodontally healthy rats (OH, n = 8); and overweight rats with periodontitis (OP, n = 8). Periodontitis was induced by ligature for 14 days. The serum cytokine' and adipokine' levels were investigated using ELISA. Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats (p<0.01). The IL-6 level was significantly higher in the OP group than in the NP group (p<0.01). The adiponectin level was significantly higher in the NH group than in the OH and OP groups (p<0.01). Leptin and resistin levels didn't differ significantly among the groups (p>0.01). Conclusions:The overweight status affected the cytokine' and adipokine' level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines (IL-4 and adiponectin) and higher serum levels of pro-inflammatory cytokine (IL-6) than their counterparts in normal weight rat groups.

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Effect of overweight/obesity on response to periodontal treatment: systematic review and a meta‐analysis

Abstract: Whereas no difference was found in clinical periodontal parameters, significant differences in inflammatory or metabolic parameters were found between overweight/obese and normal-weight patients, but existing evidence is weak.

Cited by 58 publications

References 64 publications

Commentary: Periodontal Treatment and Inflammation in Diabetes: Association or Causation?

Commentary: Periodontal Treatment and Inflammation in Diabetes: Association or Causation?

Obesity and orthodontic treatment: is there any direct relationship?

Deneysel periodontitiste fazla kilolu olma durumunun dolaşımdaki sitokinler ve adipokinler üzerine etkisi

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