Effect of Panax Ginseng on Testosterone Level and Prostate in Male Rats

Fahim, M.S.; Fahim, Z.; Harman, Joan; Clevenger, Thomas E.; Mullins, Walton; Hafez, E. S. E.

doi:10.3109/01485018208990207

Cited by 61 publications

(33 citation statements)

References 3 publications

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“…Moreover, KRG-WE was more effective than crude saponin in improving various parameters related to spermatogenesis, such as the Johnsen's score, seminiferous tubular size, percentage of tubules containing sperm, sperm count, and germ cell count. KRG-WE significantly improved the FSH and LH levels (p<0.05) ( Table 3) and increased testosterone levels in old rats (p<0.01), consistent with an earlier report [33]. The agerelated decline of Leydig cell steroidogenesis has potential implications for the decline of male fertility, and high testicular testosterone concentrations are required to maintain spermatogenesis [34].…”

Section: Discussionsupporting

confidence: 77%

Panax ginseng Improves Senile Testicular Function in Rats

Hwang¹,

Sohn²,

Wee³

et al. 2010

Journal of Ginseng Research

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Section: Discussionsupporting

confidence: 77%

Panax ginseng Improves Senile Testicular Function in Rats

Hwang¹,

Sohn²,

Wee³

et al. 2010

Journal of Ginseng Research

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“…These positive aphrodisiac effects of ginseng may be attributed to the enhancement of nitric oxide release from endothelial cells of penile corpus cavernosum and consequent relaxation (122). Furthermore, Fahim et al (123) and Bahrke and Morgan (124) reported that Panax ginseng produced a dose-related increase in serum testosterone levels and American ginseng reduced the plasma level of prolactin hormone in rats. Testosterone might mediate the heightened copulatory behavior in ginseng-treated animals, while prolactin altered it.…”

Section: Aphrodisiac Effect Of Ginsengmentioning

confidence: 95%

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Gille²,

et al. 2006

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Abstract. Ginseng, the root of Panax species, is a well-known herbal medicine. It has been used as a traditional medicine in China, Korea, and Japan for thousands of years and is now a popular and worldwide used natural medicine. The active ingredients of ginseng are ginsenosides which are also called ginseng saponins. Recently, there is increasing evidence in the literature on the pharmacological and physiological actions of ginseng. However, ginseng has been used primarily as a tonic to invigorate week bodies and help the restoration of homeostasis. Current in vivo and in vitro studies have shown its beneficial effects in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency, and hepatotoxicity. Moreover, recent research has suggested that some of ginseng's active ingredients also exert beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases. In general, antioxidant, anti-inflammatory, anti-apoptotic, and immune-stimulatory activities are mostly underlying the possible ginseng-mediated protective mechanisms. Next to animal studies, data from neural cell cultures contribute to the understanding of these mechanisms that involve decreasing nitric oxide (NO), scavenging of free radicals, and counteracting excitotoxicity. In this review, we focus on recently reported medicinal effects of ginseng and summarize the current knowledge of its effects on CNS disorders and neurodegenerative diseases.

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“…Rats treated with 5% Panax Ginseng in their diet for 60 days experienced a significant increase in blood testosterone level [46]. Research has also shown that Panax ginseng enhances the libido possibly through its effects on the CNS and gonadal tissues, as well as by increasing stamina during intercourse [110].…”

Section: Non-herbal Dietary Supplementsmentioning

confidence: 97%

“…We are presently completing a study in our lab involving DAA supplementation, which should provide additional evidence for or against the use of this amino acid for purposes of testosterone elevation. [41][42][43], ginkgo biloba [44,45], ginseng [46,47], passionflower extract (passiflora incarnate) [22,40,101], Longjack root (eurycoma longifolia) [38,39,102], and tribulus terrestris [17,24,48] are all touted to have health benefits and to increase testosterone levels. Of these, Longjack root and tribulus terrestris are of particular interest in the research community and will be explored in greater detail throughout the remainder of this review.…”

Section: Nutrient Intakementioning

confidence: 99%

“…These include but are not limited to: astragalus root (Astragalus membranaceus) [32][33][34], Chinese yam [35], Greek hay (fenugreek seed extract) [36], barrenwort (herba epimedium) [37], Longjack root (eurycoma longifolia) [38,39], passionflower extract (passiflora incarnate) [22,40], velvet bean extract (mucuna pruriens) [41][42][43], ginkgo biloba [44,45], ginseng [46,47], and tribulus terrestris [17,24,48]. Several of these ingredients have been studied in great detail with regards to impacting testosterone and GH concentrations, while others have only scant research investigating their efficacy.…”

Section: Overview Of Herbal Dietary Supplementsmentioning

confidence: 99%

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Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Gunnels¹

2014

J Plant Biochem Physiol

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Low circulating testosterone levels can present numerous problems related to the overall health and well-being of individuals, men in particular. This finding is well-documented in the literature and low testosterone appears more prevalent in older men, in particular those who are physically inactive and who present with elevated levels of body fat. Multiple botanical (herbal) products have been claimed to elevate circulating testosterone in men; however, data pertaining to the use of such herbal preparations obtained from human clinical trials are limited. This review examines the research to date pertaining to the use of herbal ingredients with regards to their ability to elevate blood testosterone levels. A collective summary of the findings indicate that certain herbal supplements may actually yield an increase in testosterone (e.g., Longjack root), while most others have little to no evidence in support of their use in human subjects. Additional, well-controlled clinical trials are needed to generate data relative to the use of herbal dietary supplements to increase circulating testosterone. Testosterone is generally measured as either "free" (unbound) or "total" (unbound and chemically bound). Men who have a morning serum testosterone level < 300 ng/dL are considered to be "low" and may be a candidate for testosterone replacement therapy-which has become more common in recent years due to the increased diagnosis of andropause [55]. Insufficient levels of testosterone due to either impaired production or uptake can present serious health consequences due to the wide array of applications of testosterone within the human body. Areas including skeletal muscle health, muscular strength, and overall well-being/vitality seem to be significantly affected by testosterone status. Increasing Circulating Testosterone: Impact of Herbal Dietary SupplementsTrintThe role of testosterone in muscle growth has been investigated extensively in both humans and animals [56][57][58][59][60][61][62]. One study in men concluded that the testosterone-induced increase in muscle volume is due to muscle fiber hypertrophy [63]. A follow-up study conducted a year later noted muscle hypertrophy in men over a period of 20 weeks of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of testosterone enanthate. The main findings from this study indicated that testosterone administration was associated with a significant increase in myonuclear number in men receiving the 300-and 600-mg doses.Muscular strength is another important factor that has been shown to be affected by testosterone levels in the body [56,61,62,[64][65][66]. A recent investigation utilized 267 men with stages 2-4 of Chronic Kidney Disease to assess the impact of testosterone level on a variety of variables [64]. This study found that testosterone was significantly and independently associated with handgrip strength, muscle mass, and nutritional status as the disease progressed. Another study explored short-term testoste...

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Effect of Panax Ginseng on Testosterone Level and Prostate in Male Rats

Cited by 61 publications

References 3 publications

Panax ginseng Improves Senile Testicular Function in Rats

Panax ginseng Improves Senile Testicular Function in Rats

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

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