Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners

Toraason, Mark; Butler, Mary Ann; Ruder, Avima M.; Forrester, Christy; Taylor, Lauralynn; Ashley, David L.; Mathias, Patty; Marlow, Kate L.; Cheever, Kenneth L.; Krieg, Edward F.; Wey, Howard

doi:10.1016/s1383-5718(03)00130-x

Cited by 31 publications

(26 citation statements)

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“…Men in our study had higher total self-reported intakes but similar plasma levels of antioxidants than women, which may explain (at least in part) why we did not observe significant differences in oxidative DNA damage levels by sex. Although we were unable to find other studies in which the potential race-sex interactions have been investigated, our findings are consistent with other published data (38,(46)(47)(48). For example, the overall mean oxidative DNA damage levels we observed are similar to baseline data in a recent study of choline depletion in African-American and White healthy adults; however, results were not stratified by race (38).…”

Section: Discussionsupporting

confidence: 81%

“…The authors noted that these differences were not explained by diet or lifestyle factors and that all participants were nonsmokers (46). Similarly, Toraason et al (47) found statistically significantly lower oxidative DNA damage levels in AfricanAmericans than Whites in a study of female dry cleaners. Considering that oxidative DNA damage is a potential mechanism associated with cancer risk and that our study population was young and relatively healthy, the relationship between race and oxidative DNA damage needs to be explored further in other studies that also include those at elevated risk of oxidative DNA damage.…”

Section: Discussionmentioning

confidence: 93%

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Associations of Antioxidant Nutrients and Oxidative DNA Damage in Healthy African-American and White Adults

Watters

Satia

Kupper

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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High antioxidant intake has been shown to reduce cancer risk and may also mitigate the effects of oxidative DNA damage, which is hypothesized to be causally linked to carcinogenesis. This study examined potential racial differences in (a) dietary intakes and plasma concentrations of vitamin C, vitamin E, and carotenoids and oxidative DNA damage and (b) associations between plasma antioxidants and oxidative DNA damage. Data were from a cross-sectional study of 164 generally healthy nonsmoking African-Americans and Whites in North Carolina, ages 20 to 45 years, equally distributed by race and sex. Participants completed a demographic and health questionnaire, four 24-h dietary recalls, and a dietary supplement inventory; had height and weight measured; and provided a semifasting blood sample. African-Americans had statistically significantly lower plasma concentrations of vitamin E, A-carotene, B-carotene, and lutein + zeaxanthin than Whites, as well as lower self-reported intake of most antioxidants. Levels of oxidative DNA damage, measured using the alkaline comet assay, were lower in African-Americans than Whites. An inverse association between lycopene and oxidative DNA damage (r = À0.20; P = 0.03) was found in the combined study population after adjusting for sex, age, body mass index, passive smoke exposure, physical activity, education, income, and alcohol intake. There was also a positive association of vitamin E with oxidative DNA damage in the total population (r = 0.21; P = 0.02) and in AfricanAmerican men (r = 0.63; P = 0.01) after adjusting for covariates. This study is among the first to examine these associations in a sample of healthy adults with an adequate representation of African-Americans. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1428 -36)

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 93%

Associations of Antioxidant Nutrients and Oxidative DNA Damage in Healthy African-American and White Adults

Watters

Satia

Kupper

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The lymphocytic 8-OH-dG level was reported to be lower than the controls in cases of workers exposed to oxidative damage, such as smokers, flight engineers exposed to cosmic radiation, and dry cleaners exposed to perchloroethylene (Zwingmann et al 1998;Nia et al 2001;Toraason et al 2003). These authors explained that the phenomenon was the result of upregulation of the primary defenses with oxidative damage and/or the DNA repair system activating due to the oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Negative association between serum dioxin level and oxidative DNA damage markers in municipal waste incinerator workers

Yoshida

Kumagai

Tabuchi

et al. 2005

Int Arch Occup Environ Health

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“…Lipid-derived aldehydes (LDAs) such as malondialdehyde (MDA), bind covalently with proteins to form MDA-protein adducts (Khan et al, 2002; Ben Mansour et al, 2010), and higher levels of MDA-modified proteins have been observed in AD patients (Frostegard et al, 2005; Kurien and Scofield, 2008; Ben Mansour et al, 2010; Wang et al, 2010), suggesting a potential role of LDAs in ADs. PCE exposure has also been reported to lead to oxidative stress both from in vivo and in vitro studies (Chen et al, 2002; Green et al, 1990; Lash and Parker, 2001; Salahudeen, 1998; Toraason et al, 1999, 2003; Zhu et al, 2005). These evidences led us to hypothesize that PCE exposure could lead to an autoimmune response/disease via its ability to induce oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune potential of perchloroethylene: Role of lipid-derived aldehydes

Wang

Ansari

et al. 2017

Toxicology and Applied Pharmacology

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Tetrachloroethene (perchloroethylene, PCE), an ubiquitous environmental contaminant, has been implicated in inducing autoimmunity/autoimmune diseases (ADs), including systemic lupus erythematosus (SLE) and scleroderma in humans. However, experimental evidence suggesting the potential of PCE in mediating autoimmunity is lacking. This study was, therefore, undertaken to explore PCE’s potential in inducing/exacerbating an autoimmune response. Six-week old female MRL+/+ mice, in groups of 6 each, were treated with PCE (0.5 mg/ml) via drinking water for 12, 18 and 24 weeks and markers of autoimmunity and oxidative stress were evaluated. PCE exposure led to significant increases in serum anti-nuclear antibodies (ANA), anti-dsDNA and anti-scleroderma-70 (anti-Scl-70) antibodies at 18 weeks and, to a greater extent at 24 weeks, suggesting that PCE exposure exacerbated autoimmunity in our animal model. The increases in autoantibodies were associated with time-dependent increases in malondialdehyde (MDA)-protein adducts and their antibodies, as well as significantly decreased levels of antioxidants GSH and SOD. The splenocytes isolated from mice treated with PCE for 18 and 24 weeks showed greater Th17 cell proliferation and increased release of IL-17 in culture supernatants following stimulation with MDA-mouse serum albumin adducts, suggesting that MDA-modified proteins may act as an immunologic trigger by activating Th17 cells and contribute to PCE-mediated autoimmunity. Our studies thus provide an experimental evidence that PCE induces/exacerbates an autoimmune response and lipid-derived aldehydes (such as MDA) contribute to this response.

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Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners

Cited by 31 publications

References 50 publications

Associations of Antioxidant Nutrients and Oxidative DNA Damage in Healthy African-American and White Adults

Associations of Antioxidant Nutrients and Oxidative DNA Damage in Healthy African-American and White Adults

Negative association between serum dioxin level and oxidative DNA damage markers in municipal waste incinerator workers

Autoimmune potential of perchloroethylene: Role of lipid-derived aldehydes

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