Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials

Polyzos, Nikolaos P.; Polyzos, Ilias P; Mauri, Davide; Tzioras, Spyridon; Tsappi, Maria; Cortinovis, Ivan; Casazza, Giovanni

doi:10.1016/j.ajog.2008.09.020

Cited by 120 publications

(80 citation statements)

References 21 publications

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“…Their results were in accordance with our results, they concluded that preexisting periodontal disease in the second trimester of pregnancy increases the risk of preterm labor with odds ratio of 4.45 to 7.07 for subjects with generalized periodontitis. Some interventional studies are also in support of our study [24][25][26], provided periodontal treatment before 28 weeks of gestation for 200 women compared to 200 women who were not treated, periodontal therapy during pregnancy was found to significantly reduces the rates of preterm labor and low birth weight in women with periodontal disease. They also concluded that periodontal disease was the strongest factor among other risk factors related to Preterm Labor and Low birth Weight odds ratio of 4.7.…”

Section: Discussionmentioning

confidence: 72%

Periodontal Disease and Preterm Birth, is There any Relationship?

Kawar¹,

Partovi²

2016

J Interdiscipl Med Dent Sci

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Aim: Prematurity and low birth weight are major causes of neonatal morbidity, mortality and long-term disability. The purpose of this study was to determine if an association exists between periodontal disease and preterm birth (PT).Material and methods: 59 females from the delivery ward at St. Mary's Health Center, St. Louis, MO. Group I had 29 women who had Preterm birth (PT). Group II had 30 women whose babies were born full term (T). Full-mouth periodontal examination performed. Data collected about risk factors: race, maternal age, pregnancy complications; infections/inflammation; number of previous pregnancies and chemical abuse. Mothers were considered to have moderate to severe periodontal disease if ≥ 10% of sites measured ≥ 5 mm probing depth. Nominal logistic regression analysis used to calculate the odds of having a preterm birth infant having moderate to severe periodontal disease while adjusting for other risk factors.Results: After adjustment for smoking, preeclampsia, and infections/inflammation other than periodontitis, a statistically significant association was found between preterm birth and moderate to severe periodontitis (odds ratio = 5.8, 95% CI = 1.2-37.5, p = 0.04). Conclusion:Moderate to severe periodontal disease may be an independent risk factor for preterm birth.

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Section: Discussionmentioning

confidence: 72%

Periodontal Disease and Preterm Birth, is There any Relationship?

Kawar¹,

Partovi²

2016

J Interdiscipl Med Dent Sci

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“…Mais une fois encore, les réponses divergent : certains auteurs affirment que ces traitements sont efficaces pour prévenir la prématurité [69][70][71][72][73][74][75] alors que d'autres arrivent à une conclusion opposée [19,60,61,[76][77][78]. Ainsi, Polyzos et al considèrent que les traitements parodontaux réduisent significativement l'incidence des prématurités [70] tandis que Stamilio et al, dans un éditorial publié dans l'American Journal of Obstetrics and Gynecology, concluent que, sur la base des données actuelles, les traitements parodontaux ne peuvent pas être recommandés pour la prévention de la prématurité [79]. Macones et al signalent même que les traitements parodontaux pourraient être à l'origine de certaines formes de prématurité [77].…”

Section: Approche Thérapeutiqueunclassified

Lien entre parodontopathies et prématurité : analyse critique de 15 ans de recherche

Gunepin¹,

Derache

2010

Med Buccale Chir Buccale

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Mots clés :parodontopathie / grossesse / accouchement prématuré Résumé -En raison du taux d'incidence élevé, de la gravité des complications, de la lourdeur de la prise en charge et des possibilités en terme de prévention, les nouveau-nés prématurés représentent un des domaines d'intérêt pour la recherche médicale. La médecine bucco-dentaire prend part à ces travaux de recherche depuis 1996 en essayant de déterminer l'existence d'un lien entre les maladies parodontales et la prématurité. Nous proposons ici une revue critique de la littérature internationale portant sur les travaux tendant à établir l'existence de ce lien, à la fois sur la forme (méthodologie) et sur le fond (conclusions). Toute tentative de méta-analyse et d'élaboration de recommandations achoppe sur le caractère individuel de chaque étude car les critères utilisés pour définir la maladie parodontale et la prématurité sont diffé-rents ce qui conduit inéluctablement à des conclusions divergentes. Cependant, en étudiant la bactériémie et l'inflammation spécifiques des maladies parodontales et leurs conséquences sur la grossesse, la biologie semble constituer un axe de recherche prometteur qui devrait permettre de préciser le lien entre maladie parodontale et prématurité. Key words:periodontal disease / pregnancy / preterm birth Abstract -Periodontal diseases and preterm birth: a review of 15 years of medical research. The delivery of preterm babies (under 37 weeks f gestation) is a significant public health issue. This problem is associated with both high postnatal mortality rate and higher risk of morbidity due to sequelae. Despite clinical researches, in 40% of cases, aetiology of preterm birth remains unknown and the preterm birth rates have not only not declined but also have increased over the last two decades (7% in France, 13% in the United States).

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“…3,[35][36][37][38][39][40][41][42][43] Few other clinical questions have been studied with such rigor. A meta analysis of 7 of the 10 trials was performed by Polyzos and colleagues 44 and suggested a benefit to periodontal treatment in reducing preterm birth. However, five of the seven trials included in this meta-analysis had fewer than 500 patients.…”

Section: Efficacy Of Periodontal Disease Treatment On Reducing Adversmentioning

confidence: 99%