Effect of periodontal therapy on circulating levels of endotoxin in women with periodontitis: A pilot clinical trial

Abstract

SRP can lead to endotoxemia, possibly by release of endotoxins by bacteria of periodontal origin, into the systemic circulation.

Effect of scaling and root planing on level of immunoglobulin E and immunoglobulin G4in children with gingivitis and house-dust mite allergy: A pilot randomised controlled trial

“…37 The main purpose of dental SRP is to restore healthy gingivae by completely removing dental plaque, calculus and toxic substances such as LPS that trigger gingival inflammation, from the tooth surface. 38 This strategy may cause a drastic reduction in the number of subgingival microorganisms as well as a change in the composition of the plaque from one with more gram-negative anaerobic bacteria (Pg) to one with more gram-positive facultative bacteria (Streptococcus salivarius, Streptococcus gordonii, Streptococcus mutans, Streptococcus sanguinis and some Lactobacillus species). Therefore, this leads to less exposure to LPS, which is mainly produced by gram-negative bacteria.…”

Microbiome impact on metabolism and function of sex, thyroid, growth and parathyroid hormones.

“…He pointed out some LPS features similar to human hormones: 1. its exposure arises from endogenous stores (commensal, Gram-negative bacteria of the gastrointestinal tract), 2. it has a dedicated carrier protein, 3. it interacts with specific cellular receptor, 4. its signaling is specifically modulated by endogenous mechanisms and in turn LPS downstream signal interferes with endogenous hormones pathways. Endotoxemia and thus increased LPS influence on host occur under various conditions, such as major vascular surgery (Roumen et al, 1993), cigarette smoking (Hasday et al, 1999), mechanical ventilation (Nahum et al, 1997), laparoscopic abdominal surgery (Schietroma et al, 2006(Schietroma et al, , 2013, colorectal carcinoma (Iarŭmov et al, 2004), high-fat diet (Erridge et al, 2007), inflammatory bowel disease (Aoki, 1978), inten-sive care (Guidet et al, 1994), stomatological intervention and tooth-brushing (Jacob et al, 2012). Increased translocation of LPS in leaky gut syndrome may cause chronic dysfunction of some elements of endocrine and other systems (Maes et al, 2008).…”

Lesões endo-periodontais combinadas

“…Dessa forma, o LPS atuaria como um potente estimulador de células inflamatórias tendo como consequência a destruição óssea periodontal (Duque, 2016). Jacob et al, 2012, avaliaram níveis de endotoxina na circulação sangüínea de pacientes com periodontite crônica, através do ensaio semi quantitativo LAL, imediatamente após processos de raspagem e alisamento radicular. Eles observaram um aumento significativo nos níveis sangüíneos de endotoxina 15 minutos após a terapia periodontal (Duque, 2016).…”