Effect of pH and temperature on doxorubicin hydrochloride release from magnetite/graphene oxide nanocomposites

Farazi, R.; Vaezi, Mohammad; Molaei, Mohammad Jafar; Saeidifar, Maryam; Behnamghader, Aliasghar

doi:10.1016/j.matpr.2018.04.184

Cited by 25 publications

(12 citation statements)

References 19 publications

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“…This possibility has been corroborated by the case of Fe 3 O 4 (magnetite) and γ-Fe 2 O 3 (maghemite) nanoparticles, which have recently been extensively exploited for biomedical applications, including magnetic resonance imaging (MRI) and hyperthermia. [10][11][12][13][14][15] For the latter, malignant tumours are more sensitive to heat than normal tissues at around 41-47°C. Once magnetic metal nanoparticles enter cancer cells and are subjected to an alternate magnetic field, they absorb energy, with the relaxation effect producing a heating effect to cause the death of the cancer cells.…”

Section: Introductionmentioning

confidence: 99%

ROS-Generating Amine-Functionalized Magnetic Nanoparticles Coupled with Carboxymethyl Chitosan for pH-Responsive Release of Doxorubicin

Obireddy¹,

Lai²

2022

IJN

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Magnetic nanoparticles have been used in diverse pharmaceutical applications because they can potentially be used to target specific sites. In the present work, a new type of nanocomposites is designed as a carrier of controlled bioactive agent delivery. Methods: Amine-functionalized magnetic nanoparticles (amine-MNPs) are coupled with carboxymethyl chitosan (CMC) to generate the nanocomposites, namely MNPs-CMC, which can be further loaded with doxorubicin (DOX) to produce MNPs-CMC-DOX. The generated nanocomposites are characterized by using various techniques (including FTIR, 1 H-NMR, DSC, TGA, SEM, TEM and XRD). In vitro drug release studies are conducted in PBS with different pH values (1.2 and 6.8) at different temperatures (25°C and 37°C). The toxicity of the nanocomposites is tested in MCF-7 and 3T3 cells. The ROS-generating capacity of the nanocomposites is determined in treated cells using 2',7'-dichlorodihydrofluorescein diacetate. Results: The structures of MNPs, CMC, and nanocomposites are confirmed by FTIR, XRD, and 1 H-NMR data reveals the formation of CMC from chitosan (CS). The size of MNPs is estimated by TEM to be around 25 nm. After conjugation with CMC, the size of the nanocomposites increases to 46-57 nm. Based on the release profiles of MNPs-CMC-DOX, our nanocomposites are pH-responsive. In addition, our nanocomposites show reactive oxygen species (ROS)-generating capacity and cell type-dependent toxicity. Conclusion: Our nanocomposites show high potential for use in bioactive agent delivery. Along with their ROS-generating capacity, they warrant further development as pH-responsive carriers for therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

ROS-Generating Amine-Functionalized Magnetic Nanoparticles Coupled with Carboxymethyl Chitosan for pH-Responsive Release of Doxorubicin

Obireddy¹,

Lai²

2022

IJN

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“…In the literature, the drug–micelle hydrogen bonding interaction is much stronger at neutral and basic conditions. Therefore, the drug release from polymeric micelle considerably decreases when compared with acidic conditions 46 …”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the drug release from polymeric micelle considerably decreases when compared with acidic conditions. 46…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin

Altınkök

Açık

Karabulut

et al. 2021

Polymers for Advanced Techs

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In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)‐block‐poly(oligoethylene glycol methacrylate) (PMML‐b‐POEGMA) bearing bile acid moiety is prepared via sequential photo‐initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two‐step procedure is applied in the presence of phenylbis (2,4,6‐trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML‐b‐POEGMA) is successfully synthesized by wavelength‐selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML‐b‐POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML‐b‐POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti‐cancer drugs for combination chemotherapy.

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“…In order to investigate the release process of DOX from m MWCNTs, several tests were performed using different volumes of acetic buffer. The release of DOX is determined by factors such as temperature or pH [ 30 , 31 ]. Generally, increasing temperatures from room temperature (298 K) to body temperature leads to higher rate of DOX release from different type of careers [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Chudoba

Jażdżewska

Łudzik

et al. 2021

IJMS

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.

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Effect of pH and temperature on doxorubicin hydrochloride release from magnetite/graphene oxide nanocomposites

Cited by 25 publications

References 19 publications

ROS-Generating Amine-Functionalized Magnetic Nanoparticles Coupled with Carboxymethyl Chitosan for pH-Responsive Release of Doxorubicin

ROS-Generating Amine-Functionalized Magnetic Nanoparticles Coupled with Carboxymethyl Chitosan for pH-Responsive Release of Doxorubicin

Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

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