Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

Waters, Laura J.; Finch, Catherine V.; Bhuiyan, A.K.M.M.H.; Hemming, K.; Mitchell, John C.

doi:10.1016/j.jpha.2017.05.003

Cited by 25 publications

(20 citation statements)

References 42 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cumulative amount permeated, on the other hand, were still lower than those permeated using this formulation [ 53 ]. Similarly, in other published literature flux values were found to be comparable with that presented in literature while producing a higher cumulative concentration [ 58 ]. Additionally, the permeation achieved with this nanoemulsion was able to be maintained over a period of 22 h. This extended release profile might be attributed to the use of sodium alginate in the formulation [ 26 ].…”

Section: Resultssupporting

confidence: 86%

Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant

et al. 2021

View full text Add to dashboard Cite

Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery. Microemulsions have shown great effectiveness for the transdermal transport of lidocaine. Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation. However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging. Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT). In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated. Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC. Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM. These nanoemulsions were also able to release 90% of their content within 24-h through PDMS and pig skin and able to the drug release over a 48-h. This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.

show abstract

Section: Resultssupporting

confidence: 86%

Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Moreover, PDMS is particularly useful for studying basic permeation mechanisms, and ranking drugs and formulations through comparison of their permeation profiles [16,29,30]. For example, PDMS membrane has been reported to produce data displaying a good correlation with an in vivo system whereby the penetrant lipophilicity was the prime determinant of compound permeation [31].…”

Section: Introductionmentioning

confidence: 99%

The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane

Rodríguez‐López

Shokry

Cruz

et al. 2019

Colloids and Surfaces B: Biointerfaces

Self Cite

View full text Add to dashboard Cite

The permeation of ten model drugs through silicone membrane was analysed to investigate the effect of the presence of a biosurfactant obtained from corn steep liquor. The ten selected pharmaceutical compounds were chosen to include a diverse range of physicochemical properties, such as variable hydrophobicities, pKa's, molecular masses and degrees of ionisation. When compared with compound permeation alone, the additional inclusion of biosurfactant in the donor phase altered the rate and extent of permeation. It significantly enhanced permeation for five of the compounds, whereas it decreased permeation for four of the compounds and remained approximately the same for the tenth compound. These effects were observed at both biosurfactant concentrations considered, namely 0.005 mg/mL, i.e. below the critical micellar concentration (CMC) and 0.500 mg/mL, i.e. above the CMC of the biosurfactant. Upon analysing permeation change with respect to physicochemical properties of the compounds, it was determined that compounds with a relative molecular mass below 200 resulted in an increase in permeation with biosurfactant present, and those above 200 resulted in a decrease in permeation with biosurfactant present. This effect was therefore attributed to the formation of a drug-biosurfactant interaction that enhanced permeation of smaller compounds, yet retarded permeation for those with a higher molecular mass. These in vitro findings can be considered an indication of potential novel formulation options that incorporate biosurfactant to create transdermal products that have bespoke permeation profiles.

show abstract

“…The surface oxidation of PDMS and the increased concentration of hydroxyl groups can also lead to the formation of strong intermolecular bonds [69,70]. These reactions may change the surface properties significantly [71], either by the formation of a thin SiO x layer, by increased cross-linking, or on the contrary, by the degradation of the network structure-all depending on the experimental conditions (e.g., plasma power, exposure time, etc.). Most of the proposed interactions upon plasma/corona exposure make the surface hydrophilic [69,72], and thus the quality of surface activation is generally monitored by water drop tests (contact-angle measurements).…”

Section: Surface Activation By Oxygen Plasma Treatmentmentioning

confidence: 99%

PDMS Bonding Technologies for Microfluidic Applications: A Review

2021

View full text Add to dashboard Cite

This review summarizes and compares the available surface treatment and bonding techniques (e.g., corona triggered surface activation, oxygen plasma surface activation, chemical gluing, and mixed techniques) and quality/bond-strength testing methods (e.g., pulling test, shear test, peel test, leakage test) for bonding PDMS (polydimethylsiloxane) with other materials, such as PDMS, glass, silicon, PET (polyethylene terephthalate), PI (polyimide), PMMA (poly(methyl methacrylate)), PVC (polyvinyl chloride), PC (polycarbonate), COC (cyclic olefin copolymer), PS (polystyrene) and PEN (polyethylene naphthalate). The optimized process parameters for the best achievable bond strengths are collected for each substrate, and the advantages and disadvantages of each method are discussed in detail.

show abstract

Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

Cited by 25 publications

References 42 publications

Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant

Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant

The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane

PDMS Bonding Technologies for Microfluidic Applications: A Review

Contact Info

Product

Resources

About