Effect of polyherbal formulation on experimental models of inflammatory bowel diseases

Jagtap, Aarti; Shirke, S; Phadke, A.S

doi:10.1016/j.jep.2003.09.042

Cited by 141 publications

(72 citation statements)

References 12 publications

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“…Moreover the IFN-γ levels were significantly increased in the TNBS model in comparison with other acute and chronic models. Animal models of colitis have been employed to assess the anti-inflammatory effects of plant extracts or their components, polyherbal formulation and probiotics (Jagtap et al 2004;Mahgoub 2003;Osman et al 2006).…”

Section: Inflammation Dth/chs Reaction Carrageenan Paw Oedema Colimentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

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Juhás Š., D. Bujňáková, P. Rehák, Š. Čikoš, S. Czikková, J. Veselá, G. Iľková, J. Koppel: Anti-Inflammatory Effects of Thyme Essential Oil in Mice. Acta Vet. Brno 2008, 77: 327-334. Plant essential oils are plant secondary metabolites possessing various pharmacological properties, primarily anti-oxidative, antimicrobial or immunomodulatory ones. The aim of this work was to study the effects of thyme essential oil dietary administration in murine DTH/ CHS reaction, carrageenan paw oedema and TNBS colitis. Thyme essential oil was added to the murine diet at three concentrations (5000, 2500 and 1250 ppm) and fed to Balb/c mice. The extent of ear swelling in DTH/CHS reaction and paw oedema induced by carrageenan application was measured using the Mitutoyo thickness gauge. In the model of TNBS colitis we evaluated the changes in body weight, the colon weight : body weight ratio, bacterial translocation to mesenteric lymph nodes, and macroscopical and histological scores. IL-1 and IL-6 messenger RNA expression in colonic samples of one experimental group were assessed using quantitative real-time reverse transcriptase PCR. Dietary supplementation with 5000 ppm of thyme essential oil significantly decreased paw oedema and ear swelling. This thyme essential oil concentration caused a significant inhibition of total mRNA IL-1 expression in the mouse colon, and markedly decreased the macroscopic and microscopic scores of colitis. On the other hand, the 1250 ppm of thyme essential oil in diet increased ear oedema induced by oxazolone application in mice. Our study indicates that thyme essential oil is able to affect murine experimental inflammatory models depending on the concentration used. It is concluded that the anti-inflammatory effects of thyme essential oil should be interpreted with a caution due to its contradictory, dose-related effects.

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Section: Inflammation Dth/chs Reaction Carrageenan Paw Oedema Colimentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

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“…According to Chopra 4 , large quantity of mucilage which acts as demulcent that is effective in diarrhoea is present in the fruit's pulp. A. marmelos has been shown to be effective in experimental models of irritable bowel syndrome where diarrhoea is a prominent symptom [6][7][8][9] . The unripe fruit of A. marmelos being an astringent, is said to be an excellent remedy for diarrhoea, due to tannin or mucilaginous substance 10 however, literature lacks the experimental evidence of tannin as an antidiarrhoeal agent.…”

Section: Introductionmentioning

confidence: 99%

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

Taqvi

Versiani

Imran

et al. 2018

Bangladesh J Med Sci

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Objective: To investigate and determine the antidiarrhoeal and spasmolytic potential of fruit of Aegle marmelos is due to CCBs compounds and not tannic acid. Materials and methods: The extract of ripe and dry fruit of A. marmelos (Am.Cr) was prepared in methanol: water (70:30). The antidiarrhoeal activities of the extract, loperamide and tannic acid were studied in vivo; in castor oil induced diarrhoeal model in mice whereas spasmolytic effect was studied in vitro; in isolated mice ileum. Calcium channel blocking (CCB) activity was investigated after preincubation of mice ileum by Am. Cr or loperamide and subsequent adding of K + 80 mM. Results: Am. Cr inhibited castor oil-induced diarrhoea: onset of diarrhoea, total no. of faeces, and total no. of wet faeces dose-dependently, the dose of 800 mg/mL was found statistically significant, total weight of feces and total weight of wet faeces were also inhibited. Concentration-dependent inhibition of spontaneous contraction and contractile effect of K + 80 mM after pre-incubation by Am. Cr were confirmed in isolated mice ileum. The results of Am. Cr are comparable with Loperamide. Tannic acid produced neither antidiarrhoeal effect nor exhibited CCB activity, however relaxant effect was observed in isolated mice ileum. Conclusion: The antidiarrhoeal and spasmolytic effects of Am.Cr may be mediated through compounds which posses CCB effect. Tannic acid exhibited relaxant effect only which is not sufficient evidence scientifically to classify as antidiarrhoeal.

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“…37,38) Epidemiological studies have almost confirmed that non steroidal anti-inflammatory drugs reduce the incidence of AD. 39) Foeniculum vulgare, 40) Boerhaavia diffusa, 41) Celastrus paniculatus, 42) Centella asiatica, 43) Cyperus rotundus, 44) Eclipta alba, 45) Elettaria cardamomum, 46) Phyllanthus emblica, 47) Glycyrrhiza glabra, 48) Ocimum sanctum, 49) Piper longum, 50) Zingiber officianale, 51) and Withania somnifera 52) have been proved as anti-inflammatory agents, which might protect from the development of inflammatory lesions in brain.…”

Section: Discussionmentioning

confidence: 99%

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

Parle

Mani

2007

JOURNAL OF HEALTH SCIENCE

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The present study was aimed at investigating the effects of Abana, an Ayurvedic herbomineral preparation on memory and brain cholinesterase activity in mice. Drug Abana was administered orally in three doses (50, 100 and 200 mg/kg) for fifteen days to different groups of young and aged mice. Elevated plus maze and passive avoidance apparatus served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageinginduced amnesia served as the interoceptive behavioral models. Brain cholinesterase activity was also estimated. Abana (50, 100 and 200 mg/kg, orally (p.o.)) produced a dose-dependent improvement in memory scores of young and aged mice. Furthermore, it reversed the amnesia induced by scopolamine (0.4 mg/kg, intraperitoneally (i.p.)) and diazepam (1 mg/kg, i.p.). Interestingly, brain cholinesterase activity was reduced by Abana administered orally for 15 days. It may prove to be a useful remedy for the management of Alzheimer's disease.

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Effect of polyherbal formulation on experimental models of inflammatory bowel diseases

Cited by 141 publications

References 12 publications

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

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