Effect of Protein Deprivation of Male Weanling Rats on the Kinetics of Hepatic Microsomal Enzyme Activity

Nitrosamine Metabolism in Protein-Deficient Weanling Rats during the Process of Repletion

“…This should be expected since the microsomal enzyme system in the liver, which deals with foreign compounds, chemicals and drugs, is known to fall to a low level during feeding of a protein-free diet or one low in protein content to adult and weanling rats [17][18][19], and so would tend to adjust itself as a result of dietary protein rehabilitation.…”

Effect of Dietary Protein and Lipid on the Activity of Hepatic Mixed-Function Oxidase System in Young and Adult Rats

“…In growing rats, the depression of this enzyme system is well known [Kato et al, 1962;McLean and McLean, 1966;Mgbodlie and Campbell, 1972]. However, no significant advantages were seen in adult rats offered 20% casein diet over the 10% casein diet in terms of growth rate and MFO activity.…”

Protein deficiency and drug interactions: A Review

“…There is abundant evidence that quantitative or qualitative dietary protein deficiency is associated with a decrease in the activity of several hepatic drug-metabolizing enzymes [Anthony, 1973;Campbell, 1977;Campbell and Hayes, 1974;Eriksson et al, 1975: Hospador andManthei, 1968;Kato et al, 1962Kato et al, , 1968Marshall and McLean, 1969;McLean and McLean, 1966;Mgbodile and Campbell, 1972;Miranda and Webb, 1973;Newberne et a]., 1978. Enzymes of the intestinal endoplasmic reticulum [Chhabra and Tredger, 19781, serum and liver cholinesterase [Casterline and Williams, 1969, 197 I], and acetyl-CoA synthetase [Gerson and Wong, 19781 (and perhaps other enzymes) are also affected by protein deficiency.…”