Effect of quercetin on oxidative stress and liver function in beta-thalassemia major patients receiving desferrioxamine: A double-blind randomized clinical trial

Abstract

Background:Blood transfusion therapy is lifesaving for beta-thalassemia major patients, yet it indirectly causes complications such as oxidative stress and liver dysfunction. In the present study, we investigated the effect of quercetin supplementation on oxidative stress and liver function in beta-thalassemia major patients.Materials and Methods:In this double-blind clinical trial, 84 beta-thalassemia patients who received desferrioxamine (DFO) were randomly assigned to two groups; the treatment group received 500 mg quercetin tablet daily for 12 weeks, and the control group received placebo. In addition to demographic and anthropometric assessment, malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were biochemically assessed to detect the effect of quercetin on oxidative stress and liver function, respectively. The data were analyzed using SPSS 21. P < 0.05 was considered statistically significant.Results:Before adjusting for confounding variables, within-group comparison showed that quercetin supplementation reduced ALT (P < 0.001) and TAC (P < 0.001) significantly. Between-group comparison using analysis of covariance analysis though showed that quercetin could significantly reduce ALT (P = 0.002), but there was an insignificant increase in SOD and TAC, and insignificant decrease in GPx, MDA, AST, and ALP (P > 0.05).Conclusion:According to our results, consumption of 500 mg quercetin supplement daily for 3 months along with DFO treatment might be able to alter liver function, but not the oxidative stress in beta-thalassemia major patients.

Evaluation of the effect of the combination of glucosamine derivatives with quercetin on the morphofunctional state of the thymus and spleen of rats under the toxic effect of doxorubicin

“…Кверцетин -флавоноїд, який володіє значною фармакологічною політропністю, що обумовлюється, насамперед, його антирадикальною, антиоксидантною та мембраностабілізуючою активністю. До того ж ГА та Кв володіють вираженими імунотропними властивостями (що є важливим в умовах імунодепресії, викликаної застосуванням цитостатиків), виявляючи активуючий вплив на фагоцитоз фосфоліпази лізосом імунних клітин, стимулюючи антитілоутворення тощо [8,9] . З огляду на вищезазначене метою роботи стало фармакологічне вивчення комбінації похідних ГА (ГА г/х та N-ацГА) з флавоноїдом Кв як потенційного фармакокоректора імунотоксичної дії ДОКС в експерименті на щурах.…”

Lactobacillus delbrueckii subsp. bulgaricus KLDS 1.0207 Exerts Antimicrobial and Cytotoxic Effects in vitro and Improves Blood Biochemical Parameters in vivo Against Notable Foodborne Pathogens

“…Recently, tropical fruit-derived L. plantarum strains lowered both blood glucose and total cholesterol levels in Winstar rats after 14 days of administration (P < 0.05), suggesting that probiotics can improve host health status by modulating biochemical parameters (da Costa et al, 2019). Also, the AST and ALT parameters are indicators of the proper functioning of vital organs like the liver (Hezaveh et al, 2019;Mirmozaffari, 2019). We show that although oral administration of these food pathogens negatively altered these parameters (T SA and T EC groups), the consumption of L. bulgaricus KLDS 1.0207 (T LBSA and T LBEC groups) ameliorated this situation.…”

Association Between Serum Levels of Adropin and Insulin Resistance in Patients with Beta-Thalassemia Major

“…Disturbances in the homoeostasis of serum lipids and carbohydrates as well as oxidative stress are the most common diseases brought on by iron overload in β-TM (Noetzli, Mittelman et al, 2012). In several earlier research, patients with -TM were found to have carbohydrate dysfunction, including glucose intolerance, hyperglycemia, reduced beta cell activity, and insulin sensitivity (Luo, Bajoria et al, 2019) (De Sanctis, Soliman et al, 2013 and According to some studies, oxidative stress is brought on by a weakening of the antioxidant defense system and an increase in the formation of reactive oxygen species caused by iron (Sajadi Hezaveh, Azarkeivan et al, 2019).…”