Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans

Yesavage, Jerome A.; Fairchild, J. Kaci; Mi, Zhibao; Biswas, Kousick; Davis-Karim, Anne; Phibbs, Ciaran S.; Forman, Steven D.; Thase, Michael E.; Williams, Leanne M.; Etkin, Amit; O’Hara, Ruth; Georgette, Gerald; Beale, Tamara; Huang, Grant D.; Noda, Art; George, Mark S.

doi:10.1001/jamapsychiatry.2018.1483

Cited by 143 publications

(132 citation statements)

References 21 publications

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“…Alternately, disease heterogeneity may be related to changes in FC that are challenging to predict at the individual level with current approaches. Others have reported the opposite direction of association with the largest improvements in depression being associated with the largest reductions in FC between sgACC and mDMN (66); however, their patient cohort had comorbid post-traumatic stress disorder, which may respond differently to rTMS of the lDLPFC (67). Further, both Philip et al (66) and our current report found an overall reduction in mean FC between sgACC and DMN in participants with improved depressive symptoms.…”

Section: Discussioncontrasting

confidence: 48%

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Xiao

Bentzley

Cole

et al. 2019

Preprint

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NRW and KDS have filed intellectual property on the methodology discussed in this manuscript.Major depressive disorder is common and debilitating. It has been difficult to study the brain changes associated with recovery from depression, because treatments take weeks-to-months to become effective, and symptoms fail to resolve in many people. We recently developed a type of magnetic brain stimulation called SAINT. SAINT leads to full remission from depression in 90% of people within 5 days. We used SAINT and functional magnetic resonance imaging to determine how the brain changes with rapid remission from depression. We found changes in areas of the brain associated with emotion regulation. This provides a significantly clearer picture of how the non-depressed brain differs from the depressed brain, which can be used to develop rapid and effective treatments for depression.

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Section: Discussioncontrasting

confidence: 48%

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Xiao

Bentzley

Cole

et al. 2019

Preprint

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“…Electroencephalography might represent a more thorough reflection of cortical excitability than motor evoked potentials (MEP) (Rocchi et al, 2018). Consistent with this variability in healthy subjects, another study observed that less than half of patients with major depression could achieve symptom remission after days of rTMS treatment (Yesavage et al, 2018). Here, we defined the after-effects induced by days of rTMS as long-term effect (LTE).…”

Section: Introductionmentioning

confidence: 79%

“…Although rTMS protocols may stably increase or decrease the neural excitability at the group level, high variability of the after-effect was also reported across subjects Yesavage et al, 2018). In these studies, MEP is frequently used as a readout measure.…”

Section: Individual Predictionmentioning

confidence: 99%

“…It has been widely used to map brain function of healthy subjects or alleviate clinical symptoms for neuropsychological patients. However, high variability of rTMS after-effects has also been reported in both neuroscientific and clinical studies Yesavage et al, 2018). For instance, although continuous theta-burst stimulation (cTBS) was initially proposed as an inhibitory protocol (Huang et al, 2005), a study with a larger sample size (n = 52) indicated that only 42% subjects respond to the stimulation as expected .…”

Section: Introductionmentioning

confidence: 99%

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Predicting Long-Term After-Effects of Theta-Burst Stimulation on Supplementary Motor Network Through One-Session Response

Sun

et al. 2020

Front. Neurosci.

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To understand the neural mechanism of repetitive transcranial magnetic stimulation (rTMS), the after-effects following one session or multiple days of stimulation have been widely investigated. However, the relation between the short-term effect (STE) and long-term effect (LTE) of rTMS is largely unknown. This study aims to explore whether the after-effects of 5-day rTMS on supplementary motor area (SMA) network could be predicted by one-session response. A primary cohort of 38 healthy participants underwent five daily sessions of real or sham continuous theta-burst stimulation (cTBS) on the left SMA. Resting-state functional magnetic resonance imaging (fMRI) data were acquired at the first (before and after the first stimulation) and sixth experimental day. The SMA connectivity changes after the first cTBS and after 5 days of stimulation were defined as STE and LTE, respectively. Compared to the baseline, significant STE and LTE were found in the bilateral paracentral gyrus (ParaCG) after real stimulation, suggesting shared neural correlates of short-and long-term stimulations. Region-ofinterest analysis indicated that the resting-state functional connectivity between SMA and ParaCG increased after real stimulation, while no significant change was found after sham stimulation. Leave-one-out cross-validation indicated that the LTE in ParaCG could be predicted by the STE after real but not sham stimulations. In an independent cohort, the after-effects of rTMS on ParaCG and short-to long-term prediction were reproduced at the region-of-interest level. These imaging evidences indicate that onesession rTMS can aid to predict the regions responsive to long-term stimulation and the individualized response degree.

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“…There have been four large, multicenter, randomized controlled trials on the antidepressant effect of high‐frequency prefrontal rTMS (for a total of 782 subjects studied) . Of these (291 participants), two revealed negative results with no difference in the responder rates of the real and the sham treatment groups (differently from the others, one of these studies involved adjunctive TMS and medications starting simultaneously rather than TMS as the primary treatment or monotherapy). The other two trials showed positive results, that is, 3 to 6 weeks of daily (weekdays only) high‐frequency rTMS over the left DLPFC improved clinical outcomes significantly more than placebo .…”

Section: Why Rtms Might Be Used As a Therapeutic Toolmentioning

confidence: 99%

The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

et al. 2019

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A BS TRACT: Background: Transcranial magnetic stimulation is a safe and painless non-invasive brain stimulation technique that has been largely used in the past 30 years to explore cortical function in healthy participants and, inter alia, the pathophysiology of movement disorders. During the years, its use has evolved from primarily research purposes to treatment of a large variety of neurological and psychiatric diseases. In this article, we illustrate the basic principles on which the therapeutic use of transcranial magnetic stimulation is based and review the clinical trials that have been performed in patients with movement disorders.

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Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans

Abstract: ClinicalTrials.gov Identifier: NCT01191333.

Cited by 143 publications

References 21 publications

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Predicting Long-Term After-Effects of Theta-Burst Stimulation on Supplementary Motor Network Through One-Session Response

The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

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