2009
DOI: 10.1248/bpb.32.1931
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Effect of Resveratrol on <i>Helicobacter pylori</i>-Induced Interleukin-8 Secretion, Reactive Oxygen Species Generation and Morphological Changes in Human Gastric Epithelial Cells

Abstract: Inflammatory cytokine interleukin-8 (IL-8) and reactive oxygen species (ROS) overexpressed in the gastric mucosa when exposed to Helicobacter pylori, defined as a class I carcinogen. Moreover, infection with H. pylori leads to morphological changes in co-cultured cells known as hummingbird phenomenon along with increased motility. Resveratrol, a highly abundant polyphenol in red grapes, has shown anti-inflammatory, anti-cancer, cardioprotective and neuroprotective activities. However, the effect of resveratrol… Show more

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Cited by 54 publications
(39 citation statements)
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“…Therefore, the anti-inflammatory effect of CM observed in this study might not be due to inference of bacterial binding to the host cells. Our group had shown similar effects of resveratrol 23) and curcumin, 30) and this phenomenon was referred with the previously coined term of "chemoprevention." 20) Furthermore various other medicinal plants with similar properties are under investigation by our group and will be reported elsewhere.…”
Section: )mentioning
confidence: 69%
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“…Therefore, the anti-inflammatory effect of CM observed in this study might not be due to inference of bacterial binding to the host cells. Our group had shown similar effects of resveratrol 23) and curcumin, 30) and this phenomenon was referred with the previously coined term of "chemoprevention." 20) Furthermore various other medicinal plants with similar properties are under investigation by our group and will be reported elsewhere.…”
Section: )mentioning
confidence: 69%
“…20) In this study non-bactericidal concentration of CM (SigmaAldrich, Japan) was evaluated by the method described with minor modifications. 23) Briefly, H. pylori were either left untreated or treated with CM diluted in dimethyl sulfoxide (DMSO) at various concentration range for 1 h at 37°C. Bacteria were then serially diluted and inoculated onto commercial selective Pylori agar plates (Kyokuto; Tokyo, Japan) under microaerophilic conditions as presented above.…”
Section: )mentioning
confidence: 99%
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“…Although salmeterol also seems to protect the respiratory epithelium against H. influenzae-induced damage [126], in vivo data show that inhalation of this bronchodilator may negatively influence the effective clearance of NTHi from the murine respiratory tract [127]. In contrast, resveratrol has been shown to ameliorate Serratia marcescens-induced acute pneumonia in rats [128], inhibit swarming and virulence factor expression in Proteus mirabilis [129], be a potential candidate against various Helicobacter pylori-related gastric pathogenic processes [130], and selectively inhibit N. gonorrhoeae and N. meningitidis [131]. in urinary tract infections caused by uropathogenic Escherichia coli [132].…”
Section: Impact Of Anti-inflammatory Therapies On Bacterial Respiratomentioning
confidence: 99%
“…Predominantly caused by Helicobacter pylori infection in about 50% of the world's population [2], which can colonize in the gastric antrum of all patients producing an extensive, noninvasive inflammatory reaction in the gastric mucosa [3]. It stimulates overexpression of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF-α] and interleukin [IL-1β, IL-6, and IL-8]) in gastric epithelial cells, which activate neutrophil and lead to leukocyte infiltration [4]. There is an increasing difficulties in the conventional H. pylori eradication triple therapy mostly due to antimicrobial resistance [5], which were replaced with many other H. pylori eradication protocols [6].…”
Section: Introductionmentioning
confidence: 99%