“…Moreover, it is used as textile dyeing [14], antimicrobial, anti-tumor, anti-inflammatory [15] used in cosmetics ad as food colorant [16], live stimulant, purgative, anticholesterololeamic, antitumor, antiseptic, tonic, and, antiparlinson [17]. Hypatoprotective principles that can prevent and treat liver damage [18], blocks the binding of SARS-CoV S proein to ACE2 and infectivity of S protein pseudotyped retrovirus to vero E6 cells [19], Antidiabetic, similar to insulin [20], Nephroroprotective properties [21] anticancer, antioxidant [22,23]. R. spiciforme is also an adulterant and also used also in the treatment of boils, wounds, rheumatic pain.…”