Effect of ruthenium red upon Ca2+ and Mn2+ uptake in Saccharomyces cerevisiae. Comparison with the effect of La3+

Pal, Ranu; Belde, P.J.M.; Theuvenet, A.P.R.; Peters, P.H.J.; Borst-Pauwels, G.W.F.H.

doi:10.1016/0005-2736(87)90131-3

Cited by 3 publications

(1 citation statement)

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“…Use of EGTA or calcium-depleted medium prevented death in response to carbon source depletion [66], the intracellular calcium chelator BAPTA-AM prevented death in response to glutathione depletion [67]. Ruthenium red is thought to inhibit Ca 2+ uptake by the mitochondria but possibly has a more complex effect on calcium transport [68]. This com-pound prevents death in response to several toxic flavone compounds [69,70].…”

Section: Calcium Signalingmentioning

confidence: 99%

A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors

Grosfeld

Bidiuk

Mitkevich

et al. 2021

JoF

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Cell death in response to distinct stimuli can manifest different morphological traits. It also depends on various cell death signaling pathways, extensively characterized in higher eukaryotes but less so in microorganisms. The study of cell death in yeast, and specifically Saccharomyces cerevisiae, can potentially be productive for understanding cell death, since numerous killing stimuli have been characterized for this organism. Here, we systematized the literature on external treatments that kill yeast, and which contains at least minimal data on cell death mechanisms. Data from 707 papers from the 7000 obtained using keyword searches were used to create a reference table for filtering types of cell death according to commonly assayed parameters. This table provides a resource for orientation within the literature; however, it also highlights that the common view of similarity between non-necrotic death in yeast and apoptosis in mammals has not provided sufficient progress to create a clear classification of cell death types. Differences in experimental setups also prevent direct comparison between different stimuli. Thus, side-by-side comparisons of various cell death-inducing stimuli under comparable conditions using existing and novel markers that can differentiate between types of cell death seem like a promising direction for future studies.

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