Effect of s‐methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs

Kopinski, J. S.; Fogarty, R; McVeigh, J. F.

doi:10.1111/j.1751-0813.2007.00197.x

Cited by 17 publications

(17 citation statements)

References 4 publications

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“…Consistent with this observation is the fact that certain vegetables such as cabbage and seaweed also have shown these anti-ulcer properties, and these contain significantly large amounts of SMMS [7][8][9][10][11] . Therefore, the anti-ulcer properties of SMMS have been widely studied, especially in the treatment of a variety of peptic ulcers [1,2,11,12] . Accelerated healing of gastric mucosal damage and a cytoprotective effect of SMMS is reportedly caused by increased mucin secretion [3,13] .…”

Section: Introductionmentioning

confidence: 99%

Accelerated Wound Healing by <i>S</i>-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway

et al. 2010

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S-Methylmethionine sulfonium (SMMS) is a derivative of the amino acid methionine, and is synthesized in a variety of plants. SMMS is widely referred to as vitamin U because of its potent therapeutic effect on gastrointestinal ulceration. Skin wounds are accompanied by mucosal erosion and share similar histopathological aspects with gastric ulcers, so it is plausible that SMMS may promote skin wound healing. In animal models, topical administration of SMMS for a given period of time, to both physical and chemical wounds, facilitated wound closure and promoted re-epithelialization compared with a control. In addition, single SMMS treatment was sufficient to promote the growth of human dermal fibroblasts (hDFs) as well as the migration of hDFs, which are indispensable steps for skin wound healing. The promotion of hDF proliferation and migration resulted from considerable activation of ERK1/2 by SMMS, and inhibition of ERK activity by a chemical inhibitor significantly abrogated both the promoted proliferation and migration of hDFs. Therefore, we concluded that SMMS facilitated the repair process of skin damage by activation of dermal fibroblasts, which suggests that SMMS has potential as a skin wound-healing agent.

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Section: Introductionmentioning

confidence: 99%

Accelerated Wound Healing by <i>S</i>-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway

et al. 2010

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“…The study found that SMM pretreatment at 100 mg/kg body weight prevented mucosal lesions and that SMM pretreatment ranged from 10 to 500 mg/kg body weight increased surface mucin content in ethanol‐induced gastric mucosal damage in rats (Watanabe and Others ). The administration of SMM (200 mg/kg body weight) induced reduction in symptom of esophageal gastric ulcers in pigs (Kopinski and others ). In addition, another research discovered that SMM supplementation at the level of 50 mg/kg body weight/day lessened liver damage by reducing oxidative stress in rats (Sokmen and others ).…”

Section: Introductionmentioning

confidence: 99%

“…SMM, considered as a sulfur compound, has various biological properties such as suppression of gastric disorder, trapping reactive oxygen species, and protection of a blood‐vessel (Takeuchi and others ; Hiraishi and others ; Watanabe and others ; Shin and others ; Son and Shim ). The effect of SMM with various dosages of gastric disease has been conducted by in vivo study (Watanabe and Others ; Kopinski and others ; Ichikawa and others ; Shim and Lim ). For instance, oral intake of SMM at the daily level of 500 mg/kg body weight affected biosynthesis and accumulation of mucin, resulting in enhancing the surface mucus cells in rat gastric mucosa (Ichikawa and others ).…”

Section: Introductionmentioning

confidence: 99%

Determination of S‐methyl‐L‐methionine (SMM) from Brassicaceae Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco‐2 Cells

Song

Lee

Shim

2016

Journal of Food Science

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The objectives of the current study were to determine S-methyl-L-methionine (SMM) from various Brassicaceae family vegetables by using validated analytical method and to characterize the intestinal transport mechanism of SMM by the Caco-2 cells. The SMM is well known to provide therapeutic activity in peptic ulcers. The amount of SMM from various Brassicaceae family vegetables ranged from 89.08 ± 1.68 μg/g to 535.98 ± 4.85 μg/g of dry weight by using validated ultra-performance liquid chromatography-electrospray ionization-mass spectrometry method. For elucidating intestinal transport mechanism, the cells were incubated with or without transport inhibitors, energy source, or a metabolic inhibitor. Phloridzin and verapamil as inhibitors of sodium glucose transport protein (SGLT1) and P-glycoprotein, respectively, were not responsible for cellular uptake of SMM. Glucose and sodium azide were not affected by the cellular accumulation of SMM. The efflux ratio of SMM was 0.26, implying that it is not effluxed through Caco-2 cells. The apparent coefficient permeability (P ) of SMM was 4.69 × 10 cm/s, indicating that it will show good oral absorption in in vivo.

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“…In experimental nephrotic hyperlipidemia, SMM ameliorated cholesterol and phospholipid levels in blood (Seri et al ., 1979). Moreover, SMM showed protective effect not only on rat gastro-intestinal mucosa (Ichikawa et al ., 2009) but also on oesophagogastric ulcers in pig studies (Kopinski et al ., 2007). …”

mentioning

confidence: 94%

Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-_L-Methionine

Kim

et al. 2017

Biomolecules & Therapeutics

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S-methyl-l-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of −3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhanced in vitro permeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol significantly increased the in vivo deposition of SMM in the epidermis/dermis for 12 hr, which was high enough to exert a therapeutic effect. Therefore, based on the in vitro and in vivo studies, the combination of oleic acid and ethanol was shown to be effective in improving the topical skin delivery of SMM, which may be applied in the cosmetic production process for SMM.

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Effect of s‐methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs

Cited by 17 publications

References 4 publications

Accelerated Wound Healing by <i>S</i>-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway

Accelerated Wound Healing by <i>S</i>-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway

Determination of S‐methyl‐L‐methionine (SMM) from Brassicaceae Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco‐2 Cells

Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-_L-Methionine

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Effect of s‐methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs

Cited by 17 publications

References 4 publications

Accelerated Wound Healing by <i>S</i>-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway

Accelerated Wound Healing by <i>S</i>-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway

Determination of S‐methyl‐L‐methionine (SMM) from Brassicaceae Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco‐2 Cells

Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-L-Methionine

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Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-_L-Methionine