Determination of S‐methyl‐L‐methionine (SMM) from <i>Brassicaceae</i> Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco‐2 Cells

Song, Ji-Hoon; Lee, Hae-Rim; Shim, Soon‐Mi

doi:10.1111/1750-3841.13556

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…Therefore, rutin and kaempferol-rutinoside, in the forms of glycosides, could not be accumulated in Caco-2 cells. As a derivative of methionine, vit U was absorbed into Caco-2 cells according to time, concentration, and temperature, and the amount of vit U uptake increased proportionally depending on these factors [42]. Findings from our study suggest that SGK rather than SGV could provide better absorption of specific bioactive components, leading to more benefits for health.…”

Section: Resultsmentioning

confidence: 90%

Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification

Choi

Lee

et al. 2019

Nutrients

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Graviola leaves contain much vitamin U (vit U), but their sensory quality is not good enough for them to be developed as food ingredients. Addition of excipient natural ingredients formulated alongside vit U as active ingredients could enhance not only its sensory quality but also its bioavailability. The objectives of this study were to measure the bioaccessibility and intestinal cellular uptake of bioactive components, including rutin, kaempferol-rutinoside, and vit U, from steamed extract of graviola leaves (SGV) and SGV enriched with kale extract (SGK), and to examine how much they can detoxify nicotine in HepG2 cells. The bioaccessibility of vit U from SGV and SGK was 82.40% and 68.03%, respectively. The cellular uptake of vit U in SGK by Caco-2 cells was higher than that in SGV. Cotinine content converted from nicotine in HepG2 cells for 120 min was 0.22 and 0.25 μg/mg protein in 50 μg/mL of SGV and SGK, respectively, which were 2.86 and 3.57 times higher than the no-treatment control. SGK treatment of HepG2 cells upregulated CYP2A6 three times as much as did that of SGV. Our results suggest that graviola leaf extract enriched with excipient ingredients such as kale could improve vit U absorption and provide a natural therapy for detoxifying nicotine.

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Section: Resultsmentioning

confidence: 90%

Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification

Choi

Lee

et al. 2019

Nutrients

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“…The intestine is an important organ for the metabolism of SCAAs in the body. About 20% of the SCAAs in the diet are transmethylated into cysteine and homocysteine in the intestine [69]. Cysteine is the rate-limiting amino acid of glutathione synthesis and is the main cellular antioxidant in mammals [70].…”

Section: Impacts Of Amino Acids On Piglet Intestinal Healthmentioning

confidence: 99%

Amino Acids Influencing Intestinal Development and Health of the Piglets

Mou

Yang

Yin

et al. 2019

Animals

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The amino acids and other components of diet provide nourishment for piglet intestinal development and maturation. However, early-weaned piglets struggle with tremendous stress, impairing normal intestinal health and leading to intestinal dysfunction and even death. The high prevalence worldwide of post-weaning diarrhoea syndrome (PWDS) in piglets has led to much interest in understanding the important role of nutrients in the establishment and maintenance of a functional intestinal tract. In particular, the impacts of amino acids on these functions must be considered. Amino acid levels greatly influence intestinal development in weaning piglets. The lack of amino acids can cause marked structural and functional changes in the intestine. Therefore, a comprehensive understanding of the functions of amino acids is necessary to optimize amino acid requirements of the developing intestinal tract to maximize piglet health and growth performance. This review summarizes the role of specific amino acids (arginine, glutamate, threonine, sulphur-containing amino acids (SCAAs), and branched-chain amino acids (BCAAs)) that have been proven to be beneficial for the intestinal health of weaned piglets.

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“…in addition to being inversely associated with dietary protein, is detected in cruciferous vegetables, such as cabbage and corn (31)(32)(33).…”

Section: Figurementioning

confidence: 99%

“…Each metabolite was listed as belonging to a single metabolic superpathway and subpathway, whereas they could be appropriately classified in a different manner. For example, although S-methylmethionine was reported as an amino acid and specifically related to methionine, cysteine, S-adenosyl methionine and taurine metabolism, perhaps more relevant is that it is a potential biomarker of cruciferous vegetable consumption (31)(32)(33). Nonetheless, we used the pathway designation for the sake of consistency of reporting results from this platform.…”

Section: Figurementioning

confidence: 99%

The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

Rebholz

Surapaneni

Levey

et al. 2019

The Journal of Nutrition

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Background Dietary acid load is a clinically important aspect of the diet that reflects the balance between acid-producing foods, for example, meat and cheese, and base-producing foods, for example, fruits and vegetables. Methods We used metabolomics to identify blood biomarkers of dietary acid load in 2 independent studies of chronic kidney disease patients: the African American Study of Kidney Disease and Hypertension (AASK, n = 689) and the Modification of Diet in Renal Disease (MDRD, n = 356) study. Multivariable linear regression was used to assess the cross-sectional association between serum metabolites whose identity was known (outcome) and dietary acid load (exposure), estimated with net endogenous acid production (NEAP) based on 24-h urine urea nitrogen and potassium, and adjusted for age, sex, race, randomization group, measured glomerular filtration rate, log-transformed urine protein-to-creatinine ratio, history of cardiovascular disease, BMI, and smoking status. Results Out of the 757 known, nondrug metabolites identified in AASK, 26 were significantly associated with NEAP at the Bonferroni threshold for significance (P < 6.6 × 10−5). Twenty-three of the 26 metabolites were also identified in the MDRD study, and 13 of the 23 (57%) were significantly associated with NEAP (P < 2.2 × 10−3), including 5 amino acids (S-methylmethionine, indolepropionylglycine, indolepropionate, N-methylproline, N-δ-acetylornithine), 2 cofactors and vitamins (threonate, oxalate), 1 lipid (chiro-inositol), and 5 xenobiotics (methyl glucopyranoside, stachydrine, catechol sulfate, hippurate, and tartronate). Higher levels of all 13 replicated metabolites were associated with lower NEAP in both AASK and the MDRD study. Conclusion Metabolomic profiling of serum specimens from kidney disease patients in 2 study populations identified 13 replicated metabolites associated with dietary acid load. Additional studies are needed to validate these compounds in healthy populations. These 13 compounds may potentially be used as objective markers of dietary acid load in future nutrition research studies.

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Determination of S‐methyl‐L‐methionine (SMM) from Brassicaceae Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco‐2 Cells

Cited by 7 publications

References 45 publications

Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification

Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification

Amino Acids Influencing Intestinal Development and Health of the Piglets

The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

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