The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

Rebholz, Casey M.; Surapaneni, Aditya; Levey, Andrew S.; Sarnak, Mark J.; Inker, Lesley A.; Appel, Lawrence J.; Coresh, Josef; Grams, Morgan E.

doi:10.1093/jn/nxy311

Cited by 16 publications

(14 citation statements)

References 40 publications

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“…Like Odoribacter , it is a butyrate producer and the test foods had opposite effects on its abundance in this study. Paradoxically with the seemingly healthy effects of Christensenellaceae, it was negatively correlated with catechol sulfate, a metabolite that was negatively associated with net endogenous acid production in adults with CKD [ 59 ]. This acid production is associated with an elevated risk of CKD and faster decline in GFR.…”

Section: Discussionmentioning

confidence: 99%

Effect of Added Dietary Betaine and Soluble Fiber on Metabolites and Fecal Microbiome in Dogs with Early Renal Disease

Ephraim¹,

Jewell

2020

Metabolites

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Renal diets are recommended for dogs with chronic kidney disease (CKD). This study examined the effects of foods with added betaine and fiber on the plasma and fecal metabolome and fecal microbiome in dogs with early stage CKD. At baseline, several metabolites differed between healthy dogs and those with CKD. Dogs with CKD (n = 28) received a control food, low soluble fiber plus betaine food (0.5% betaine, 0.39% oat beta-glucan, and 0.27% short-chain fructooligosaccharides (scFOS)), or high soluble fiber plus betaine food (0.5% betaine, 0.59% oat beta-glucan, and 0.41% scFOS) each for 10 weeks in different sequences. Consumption of test foods led to several favorable, significant changes in the plasma metabolome, including decreases of several uremic toxins and other deleterious metabolites, and increases in favorable metabolites compared with the control food. Only 7 fecal metabolites significantly changed with consumption of the test foods compared with the control food, largely increases in polyphenols and lignans. Few changes were seen in the fecal microbiome, though some taxa that significantly changed in response to the test foods have beneficial effects on health, with some negatively correlating with uremic toxins. Overall, foods with added betaine and soluble fiber showed positive effects on the plasma and fecal metabolomes.

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Section: Discussionmentioning

confidence: 99%

Effect of Added Dietary Betaine and Soluble Fiber on Metabolites and Fecal Microbiome in Dogs with Early Renal Disease

Ephraim¹,

Jewell

2020

Metabolites

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“…Metabolomics thus provides an integrated profile of an individual's biological status: ‘the genome defines what may happen, the metabolome defines what has happened’ 1 . Metabolomics profiles are also influenced by environmental exposure 2–8 . There are two main analytical approaches used in metabolomics research: targeted and untargeted.…”

Section: Metabolomicsmentioning

confidence: 99%

“…1 Metabolomics profiles are also influenced by environmental exposure. [2][3][4][5][6][7][8] There are two main analytical approaches used in metabolomics research: targeted and untargeted. Untargeted approaches involve comprehensive analysis of all the measurable analytes in a sample.…”

Section: Metabolomicsmentioning

confidence: 99%

Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

Koh

Kovalik

2021

ESC Heart Failure

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The purpose of this review is to explore how metabolomics can help uncover new biomarkers and mechanisms for cardiovascular ageing. Cardiovascular ageing refers to cardiovascular structural and functional alterations that occur with chronological ageing and that can lead to the development of cardiovascular disease. These alterations, which were previously only detectable on tissue histology or corroborated on blood samples, are now detectable with modern imaging techniques. Despite the emergence of powerful new imaging tools, clinical investigation into cardiovascular ageing is challenging because ageing is a life course phenomenon involving known and unknown risk factors that play out in a dynamic fashion. Metabolomic profiling measures large numbers of metabolites with diverse chemical properties. Metabolomics has the potential to capture changes in biochemistry brought about by pathophysiologic processes as well as by normal ageing. When combined with non-invasive cardiovascular imaging tools, metabolomics can be used to understand pathological consequences of cardiovascular ageing. This review will summarize previous metabolomics and imaging studies in cardiovascular ageing. These methods may be a clinically relevant and novel approach to identify mechanisms of cardiovascular ageing and formulate or personalize treatment strategies.

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“…Higher dietary acid load results from the consumption of acid-producing foods (e.g., meat and cheese) and is associated with higher risk of incident kidney disease. [31,32] Indole-3-propanoic acid may be indicative of metabolic pathways relevant to diet-disease relationships. Lysophosphatidylcholine (LPC) C24:0 was also inversely associated with the meat and fast food dietary pattern.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Markers of Southern Dietary Patterns in the Jackson Heart Study

Rebholz

Gao

Talegawkar

et al. 2021

Molecular Nutrition Food Res

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New biomarkers are needed that are representative of dietary intake. Methods and Results: We assess metabolites associated with Southern dietary patterns in 1401 Jackson Heart Study participants. Three dietary patterns are empirically derived using principal component analysis: meat and fast food, fish and vegetables, and starchy foods. We randomly select two subsets of the study population: two-third sample for discovery (n = 934) and one-third sample for replication (n = 467). Among the 327 metabolites analyzed, 14 are significantly associated with the meat and fast food dietary pattern, four are significantly associated with the fish and vegetables dietary pattern, and none are associated with the starchy foods dietary pattern in the discovery sample. In the replication sample, nine remain associated with the meat and fast food dietary pattern [indole-3-propanoic acid, C24:0 lysophosphatidylcholine (LPC), N-methyl proline, proline betaine, C34:2 phosphatidylethanolamine (PE) plasmalogen, C36:5 PE plasmalogen, C38:5 PE plasmalogen, cotinine, hydroxyproline] and three remain associated with the fish and vegetables dietary pattern [1,7-dimethyluric acid, C22:6 lysophosphatidylethanolamine, docosahexaenoic acid (DHA)]. Conclusion: Twelve metabolites are discovered and replicated in association with dietary patterns detected in a Southern U.S. African-American population, which could be useful as biomarkers of Southern dietary patterns.

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The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

Cited by 16 publications

References 40 publications

Effect of Added Dietary Betaine and Soluble Fiber on Metabolites and Fecal Microbiome in Dogs with Early Renal Disease

Effect of Added Dietary Betaine and Soluble Fiber on Metabolites and Fecal Microbiome in Dogs with Early Renal Disease

Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

Metabolomic Markers of Southern Dietary Patterns in the Jackson Heart Study

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