Effect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trial

Karimi-Nazari, Elham; Nadjarzadeh, Azadeh; Masoumi, Roghayyeh; Marzban, Ameneh; Mohajeri, Seyed Ahmad; Ramezani‐Jolfaie, Nahid; Salehi‐Abargouei, Amin

doi:10.1016/j.clnesp.2019.07.012

Cited by 47 publications

(72 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three studies described allocation concealment. There are 6 trials that used placebo to achieve satisfactory blinding effect, such as Karimi-Nazari et al [ 32 ] and Lian et al [ 34 ]. The rest 16 trials provided lifestyle management treatment or no treatment or conventional Western medicine treatment as control intervention, which makes these trials under high risk of bias.…”

Section: Resultsmentioning

confidence: 99%

“…In this process, placebo plays an important role in blinding participants and nursing providers [ 59 ]. In our study, there are 6 trials adopted blinding methods by using placebo, such as placebo the Karimi-Nazari et al [ 32 ] and Lian et al [ 34 ] trials used placebo to achieve satisfactory blinding effect. The rest 16 trials provided lifestyle management treatment or no treatment or conventional Western medicine treatment as control intervention, which makes these trials under high risk of bias.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Song

Wang

Qin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. The aim of this study was to review existing evidence on the efficiency and safety of Chinese herbal medicine for the treatment of prediabetes. Methods. Randomized controlled trials (RCTs) of Chinese herbal medicine (CHM) to treat prediabetes were searched in the following databases from their inception date onwards until 2 May 2020: MEDLINE, Cochrane, EMBASE, Web of Science, EBSCO, CINAHL, CNKI, VIP database, CBM, and Wanfang database. Quality assessment of included trials was accessed according to the guidance in Cochrane. Researchers independently assessed the validity of included trials and extracted outcome data for synthesis. RevMan 5.3 was used for the meta-analysis. Results. Twenty-two RCTs including 3923 participants were included in the study. Our findings upon the 22 RCTs showed CHM is effective in the treatment of prediabetes, which can statistically reduce the incidence of diabetes (RR = 0.48; 95% CI = (0.41, 0.57); P < 0.001 ), increase the incidence of normalization of prediabetes (RR = 1.76; 95% CI = (1.57, 1.96); P < 0.001 ), and lower FPG (MD = −0.38; 95% CI = (−0.60, −0.16); P < 0.001 ), 2hPG (MD = −1.13; 95% CI = (−1.60, −0.67); P < 0.001 ), TG (MD = −0.23; 95% CI = (−0.33, −0.13); P < 0.001 ), TC (MD = −0.34; 95% CI = (−0.52, −0.16); P < 0.001 ), and BMI (MD = −0.48; 95% CI = (−0.78, −0.18); P < 0.001 ) after treatment, and there was no difference of HbA1c ( P > 0.05 ). Conclusion. CHM is effective for the treatment of prediabetes. CHM can statistically reduce the incidence of diabetes, increase the incidence of normalization of prediabetes, and lower the FPG, 2hPG, TG, TC, and BMI levels, but with no significant difference in HbA1c. In addition, CHM was relatively safe in clinical practice. More high-quality RCTs should be conducted to strengthen the finding.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Song

Wang

Qin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…A study was done by Hoshyar et al [14] which also reported that oral administration of saffron stigma extract in obese rats significantly decreased the level of fasting blood glucose, insulin, and leptin. More-over, a randomized, double-blind, and placebo-controlled study proved that the administration of saffron in eight weeks significantly reduced the concentration of fasting blood glucose and HbA1c in obese-diabetic patient [36]. A decreased level of glucose in obese rats treated with saffron extract and crocin could be related to SREBP-1c and ChREBP activity that is responsible in regulating carbohydrate metabolism (glycolysis and glycogen synthesis) and lipogenesis (triglycerides synthesis) in the liver [37].…”

Section: Effect Of Saffron Extract and Crocin On Carbohydratementioning

confidence: 97%

Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats

Ramli

Sajak

Abas

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

The effect of saffron extract (Crocus sativus L.) and its primary compound crocin was studied on an induced obesity rat model. Our study is aimed at investigating and comparing the metabolite changes in obese and obese treated with saffron extract and crocin and at improving the understanding of the therapeutic effect of saffron extract and crocin. Two different doses of saffron extracts and crocin (40 and 80 mg/kg) were incorporated in a high-fat diet (HFD) and were given for eight weeks to the obese rats. The changes in metabolite profiles of the serum were determined using proton nuclear magnetic resonance (1H-NMR). Pattern recognition by multivariate data analysis (MVDA) showed that saffron extract and crocin at 80 mg/kg was the best dosage compared to 40 mg/kg. It also showed that both treatments work in different pathways, especially concerning glucose, lipid, and creatinine metabolism. In conclusion, although the pure compound, crocin, is superior to the saffron crude extract, this finding suggested that the saffron extract can be considered as an alternative aside from crocin in treating obesity.

show abstract

“…[7] It is a carotenoid-rich spice which has been studied for its wide-ranging medicinal properties such as antioxidant, [8] nerve sedative, [9] anti-inflammatory, [10] anticonvulsant, [11] anti-tumor, [12] hypolipidemic, and insulin resistance reducing effects . [13] Furthermore, it has used for treatment of menstruation disorders and liver disease . [14] The pharmacological activities of saffron are mainly attributed to three main constituents, including Crocin, Crocetin, and Safranal, which are also accountable for the color, taste and aroma .…”

Section: Introductionmentioning

confidence: 99%

“…[15] It also contains secondary metabolites such as flavonoids, terpenes, anthocyanins and carotenoids . [13] Another interesting activity of saffron is its effects in patients with type 2 diabetes . [16,17] Most of its hypoglycemic effects are due to the modulatory effects of saffron on inflammation and oxidative stress, the main underlying causes of diabetes mellitus and its complications .…”

Section: Introductionmentioning

confidence: 99%

Saffron supplementation effects on glycemic indices: a systematic review and meta-analysis of randomized controlled clinical trials

Sohaei

Hadi

Karimi

et al. 2020

International Journal of Food Properties

View full text Add to dashboard Cite

Existing evidence on the possible effects of saffron on glycemic indices were inconclusive. The aim of the present systematic review and meta-analysis was to clarify the effects of saffron supplementation on glycemic indices, including fasting blood glucose (FBG), fasting insulin, glycated hemoglobin (HbA1c), Quantitative Insulin Sensitivity Check Index (QUICKI) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) among both diabetic and nondiabetic patients. A systematic literature search of online databases PubMed, Scopus, ISI Web of science and Cochrane's library was conducted up to August 2020. Randomized controlled trials (RCTs) investigating the effects of saffron supplementation on glycemic indices in adults were included. A total of 15 trials involving 1139 participants were included in this systematic review and meta-analysis. Saffron supplementation resulted in a significant decrease in FBS (WMD = −5.26 mg/dL; 95% CI: −10.08 to −0.44; I 2 = 89.7%), HbA1c (WMD = −0.15%; 95% CI, −0.28 to −0.02; I 2 = 79.4%,), fasting insulin (WMD = 0.12 mIU/L; 95% CI, 0.03 to 0.20; I 2 = 26.6%), and an increase in QUICKI (WMD = 0.01; 95% CI, 0.001 to 0.009; I 2 = 78.4%) compared to control. Saffron supplementation could not reduce HOMA-IR significantly (SMD = −0.21; 95% CI, −0.45 to 0.02; I 2 = 0.0%). Saffron supplements may be beneficial to improve glyceamic indices. Therefore, saffron could be considered as a valuable adjuvant therapy regarding glycemic control of patients.

show abstract

Effect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trial

Cited by 47 publications

References 39 publications

Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats

Saffron supplementation effects on glycemic indices: a systematic review and meta-analysis of randomized controlled clinical trials

Contact Info

Product

Resources

About