Effect of <scp>K</scp>ampo extracts on urinary stone formation: An experimental investigation

Nishihata, Masaya; Kohjimoto, Yasuo; Hara, Isao

doi:10.1111/iju.12098

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…In previous studies, Nishihata et al. 16 reported that the Kampo extracts Takusha and Sanshishi showed obvious inhibitory effects on CaOx aggregation (64.2 and 84.5%, respectively) and on crystal adhesion to Madin-Darby canine kidney cells (54.6 and 88.2%, respectively). However, in our in vitro assays, RPA had a dose-dependent effect on formed crystals.…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model

Wang

et al. 2017

Renal Failure

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Objective: To examine the effect of an aqueous extract of Radix Paeoniae Alba (RPA) on the formation of calcium oxalate (CaOx) stones and the potential mechanism underlying the effect.Materials and methods: An in vitro assay was used to determine whether the RPA extract prevents the formation of CaOx or promotes CaOx dissolution. We also investigated the efficacy of the extract in vivo as a preventive and therapeutic agent for experimentally induced CaOx nephrolithiasis in rats. Various biochemical, molecular, and histological parameters were assessed in kidney tissue and urine at the end of the in vivo experiment.Results: Significant dissolution of formed crystals (8.99 ± 1.43) and inhibition of crystal formation (2.55 ± 0.21) were observed in vitro after treatment with 64 mg/mL of the RPA extract compared with a control treatment (55.10 ± 4.98 and 54.57 ± 5.84, respectively) (p < .05). In preventive protocols, the RPA extract significantly reduced urinary and renal oxalate levels and increased urinary calcium and citrate levels compared to the control. In addition, the RPA preventive protocol significantly decreased osteopontin expression, renal crystallization, and pathological changes compared to the control. These changes were not observed in rats on the therapeutic protocol.Conclusions: RPA is a useful agent that prevents the formation of CaOx kidney stones.

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Section: Discussionmentioning

confidence: 99%

“… 20 Additionally, in our experiments, RPA not only dissolved formed crystals but also inhibited crystal formation, which is analogous to the inhibitory effect of Takusha and Sanshishi on CaOx crystal formation. 16 …”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model

Wang

et al. 2017

Renal Failure

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“…One of the Kampo medicine, choreito (CRT) is indicated for the symptomatic relief of the patients with following symptoms: decreased urine volume, dysuria, and cystitis 7–9 . In particular, CRT is widely prescribed for the spontaneous excretion of urinary tract stones, 10 and it has been reported that one of its actions is to inhibit the formation of oxalate calcite stones 11 . There are also several clinical reports that administration of CRT to patients with hemorrhagic cystitis improved urinary symptoms such as dysuria, pollakisuria, urinary urgency, and residual urine 12 …”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] In particular, CRT is widely prescribed for the spontaneous excretion of urinary tract stones, 10 and it has been reported that one of its actions is to inhibit the formation of oxalate calcite stones. 11 There are also several clinical reports that administration of CRT to patients with hemorrhagic cystitis improved urinary symptoms such as dysuria, pollakisuria, urinary urgency, and residual urine. 12 The purpose of the present study is to exploratory investigate the effect of CRT on IC/BPS-like symptoms induced by tranilast.…”

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confidence: 99%

Choreito, a Kampo medicine attenuates detrusor overactivity and bladder pain symptoms in rat tranilast‐induced interstitial cystitis/bladder pain syndrome‐like model

Tokita

Sugaya²,

Nishijima³

et al. 2022

Neurourology and Urodynamics

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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory condition of the bladder. However, there are only a few medicines that are of pharmaceutical grade and reliably effective for IC/BPS symptoms. Choreito (CRT) is a pharmaceutical-grade Kampo medicine and has been widely prescribed for patients of lower urinary tract symptoms (LUTS) and BPS in Japan. In this study, we exploratory investigated the effects of CRT on the IC/BPS-like symptoms induced by tranilast. Methods:The rat IC/BPS-like model was induced by feeding administration with 0.4% tranilast. The rats were divided into the three following treatment groups: normal diet (Normal), tranilast treatment (Control), and the groups of 1% CRT (CRT) treatment for IC/BPS-like model. After 4 weeks, continuous cystmetry, locomotor, and vascular permeability was assessed. Furthermore, the cytokine levels in bladder were analyzed by the Bio-Plex suspension array system and plasma monoamine were measured.Results: Control group exhibited 14.3% decrease of locomotor activity in the dark period, and which were 20.3% increase by 1%CRT treatment. The voiding interval was shorter in control than in other groups. 1%CRT suppressed the shortening of voiding interval. Evans blue leakage of bladder wall observed 44.8% higher in control group than in the normal group. The leakage of 1% CRT group was 33.3% less than in the control group. The cytokine level of IFNγ and VEGF were elevated in the control, and CRT treatment suppressed the elevation of IFNγ in the bladder. Plasma noradrenaline was significantly reduced by CRT treatment compared normal group. Conclusion: These results suggest that CRT can be an effective therapeutic agent for the treatment of IC/BPS-like symptoms.

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“…A . orientale also has therapeutic effects on hyperlipidaemia 6,7 , chronic prostatitis 8 , chronic obstructive pulmonary disease 9 , hepatic steatosis 10 , diabetes 11 , prophylaxis of urolithiasis 12 , anti-atherosclerotic actions 13 , cholestasis 14 , chronic kidney disease 15 and cancer 16–18 .…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptome and metabolite profiling of four tissues from Alisma orientale (Sam.) Juzep reveals its inflorescence developmental and medicinal characteristics

Lin

Sun

Zhang

et al. 2019

Sci Rep

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Alisma orientale (Sam.) Juzep ( A . orientale ) is an important medicinal plant in traditional Chinese medicine. In this study, de novo RNA-seq of A . orientale was performed based on the cDNA libraries from four different tissues, roots, leaves, scapes and inflorescences. A total of 41,685 unigenes were assembled, 25,024 unigene functional annotations were obtained by searching against the five public sequence databases, and 3,411 simple sequence repeats in A . orientale were reported for the first time. 15,402 differentially expressed genes were analysed. The morphological characteristics showed that compared to the other tissues, the leaves had more chlorophyll, the scapes had more vascular bundles, and the inflorescences contained more starch granules and protein. In addition, the metabolic profiles of eight kinds of alisols metabolite profiling, which were measured by ultra-Performance liquid chromatography-triple quadrupole-mass spectrometry showed that alisol B 23-acetate and alisol B were the major components of the four tissues at amounts of 0.068~0.350 mg/g and 0.046~0.587 mg/g, respectively. In addition, qRT-PCR validated that farnesyl pyrophosphate synthase and 3-hydroxy-3-methylglutaryl-CoA reductase should be considered the critical candidate genes involved in alisol biosynthesis. These transcriptome and metabolic profiles of A . orientale may help clarify the molecular mechanisms underlying the medicinal characteristics of A . orientale .

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Effect of Kampo extracts on urinary stone formation: An experimental investigation

Cited by 12 publications

References 7 publications

Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model

Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model

Choreito, a Kampo medicine attenuates detrusor overactivity and bladder pain symptoms in rat tranilast‐induced interstitial cystitis/bladder pain syndrome‐like model

Comparative transcriptome and metabolite profiling of four tissues from Alisma orientale (Sam.) Juzep reveals its inflorescence developmental and medicinal characteristics

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