Effect of selenium on cultured bovine luteal cells

Kamada, Hiroki; Ikumo, Haruhisa

doi:10.1016/s0378-4320(96)01617-x

Cited by 22 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, FSH receptor expression and biosynthetic pathway of estradiol were predominantly influenced by selenium (Basini & Tamanini, 2000). Selenium can also stimulate luteal cell proliferation and decrease toxic lipid peroxides, and consequently elevate progesterone level affecting luteal cells (Kamada & Hodate, 1998;Kamada & Ikumo, 1997). Therefore, it can be concluded that the observed maintenance of estrous cyclicity in PCO rats, after treatment by ANGIPARSÔ, was mainly due to restoring steroid status and enabling ovaries to function normally.…”

Section: Discussionmentioning

confidence: 96%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Submit your article to this journal Results: PCO rats exhibited ovarian cystogenesis which was preserved by the application of carvedilol and ANGIPARSä. In comparison with controls, decreased level of the total antioxidant power (TAP) and higher levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in serum and ovaries (2.41 ± 0.67 versus 0.72 ± 0.11; and 0.17 ± 0.04 versus 0.05 ± 0.01; 5.48 ± 1.30 versus 10.56 ± 0.77; and 7.06 ± 1.94 versus 17.98 ± 0.98; p50.05, respectively) were detected in PCO rats. Moreover, the PCO rats exhibited hyperandrogenism due to a 3.7-fold increase in serum testosterone concentration (35.04 ± 3.17 versus 131.09 ± 13.24; p50.05) along with a 2.98-fold decrease in serum progesterone (6.19 ± 0.40 versus 18.50 ± 1.03; p50.05) and 5.2-fold decrease in serum estradiol (9.30 ± 0.61 versus 48.3 ± 2.10; p50.05) when compared with those of the control group. However, similar to the control group, normal levels of OS markers and sex hormones were detected in ANGIPARSä and carvedilol co-treated PCO rats. Besides, when compared with controls, increased levels of TNF-a (770.75 ± 42.06 versus 477.14 ± 28.77; p50.05) and insulin (1.27 ± 0.10 versus 0.36 ± 0.05; p50.05) in PCO rats were significantly inhibited by carvedilol and ANGIPARSä co-treatment. Discussion and conclusion: We evidenced the beneficial effects of carvedilol and ANGIPARSä in PCO, which underpin the new alternative approach in using these kinds of medicines in female reproductive disorders.

show abstract

Section: Discussionmentioning

confidence: 96%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…Although the critical importance of Se in the growth of various cell lines has been reported [48,49], the delineation of Se function at low concentrations in cell cycle is lacking. At supranutritional levels, Se has anticancer effects that are mediated through changes in the proliferation of certain cells, apoptosis and/or toxic effects [50,51].…”

Section: Discussionmentioning

confidence: 99%

Dietary selenium variation-induced oxidative stress modulates CDC2/cyclin B1 expression and apoptosis of germ cells in mice testis

Kaushal

Bansal

2007

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…Actually, Musicki et al [20] reported that peroxides inhibit protein and RNA syntheses in cultured luteal cells, and the accumulation of H 2 O 2 or LPO is observed in the corpus luteum at functional luteal regression [24]. A role of Se in the corpus luteum may be to degrade H 2 O 2 or peroxides as a component of GSHpx or PH-GSHpx, a supposition which is supported by data from the in vitro experiment in which Se addition to a luteal cell culture decreased the amount of LPO in the cell [17]. However, other possibilities cannot be neglected because there are many Se-containing proteins whose functions are unknown [3,28].…”

mentioning

confidence: 81%

“…Our previous experiments using cultured bovine luteal cells showed the possibility that Se is able to maintain the function of the corpus luteum [17]. Namely, Se addition to a luteal cell culture increased the progesterone concentration in that medium.…”

mentioning

confidence: 97%

Effect of Dietary Selenium Supplementation on the Plasma Progesterone Concentration in Cows.

Kamada

Hodate

1998

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT. The effect of selenium (Se) supplementation to the diet on the plasma progesterone concentration was investigated in nonlactating and non-pregnant cows. Italian ryegrass wafers and concentrates, with or without 0.5 ppm of Se, were fed to cows at a maintenance level. The plasma Se concentrations in the each treatment were 0.047 ppm (-Se) and 0.081 ppm (+Se), respectively. Se supplementation did not affect the length of the estrous cycle, but it did increase the concentration of plasma progesterone in the estrous cycle (P<0.001). These results suggest the possibility that Se contributes to the progesterone production of corpus luteum. -KEY WORDS: cattle, progesterone, selenium.

show abstract

Effect of selenium on cultured bovine luteal cells

Cited by 22 publications

References 22 publications

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Dietary selenium variation-induced oxidative stress modulates CDC2/cyclin B1 expression and apoptosis of germ cells in mice testis

Effect of Dietary Selenium Supplementation on the Plasma Progesterone Concentration in Cows.

Contact Info

Product

Resources

About