Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type‐specific induction of apoptosis and mitotic catastrophe

Cotugno, Roberta; Fortunato, Rosaria; Gallotta, Dario; Braca, Alessandra; Tommasi, Nunziatina De; Belisario, Maria Antonietta

doi:10.1111/j.1365-2184.2011.00796.x

Cited by 37 publications

(23 citation statements)

References 55 publications

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“…The cytotoxic and apoptotic effects of STLs have been investigated in vitro against several cancer cell lines [70–75]. In result of all the chemical and pharmacological research on STLs, substances such as parthenolide and its synthetic analog, dimethylaminoparthenolide (DMAPT), thapsigargin, the artemisinin derivatives artemether and artesunate are presently in cancer clinical trials [56].…”

Section: Discussionmentioning

confidence: 99%

Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem

Shoaib

Shah

Ali

et al. 2017

BMC Complement Altern Med

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BackgroundSesquiterpene lactones (STLs) make a diverse and huge group of bio-active constituents that have been isolated from several plant families. However, the greatest numbers are present in Asteraceae family having more than 3000 different reported structures. Recently several researchers have reported that STLs have significant antioxidant and anticancer potentials.MethodsTo investigate the antioxidant, anticancer and antinociceptive potentials of STLs, gravity column chromatography technique was used for isolation from the biologically rich chloroform fraction of Artemisia macrocephala Jacquem. The antioxidant activity of the isolated STLs was determined by DPPH and ABTS free radical scavenging activity, anticancer activity was determined on 3 T3, HeLa and MCF-7 cells by MTT assay while the antinociceptive activity was determined through acetic acid induced writhings, tail immersion method and formalin induced nociception method.ResultsThe results showed that the STLs of Artemisia macrocephala possesses promising antioxidant activity and also it decreased the viability of 3 T3, HeLa and MCF-7 cells and mild to moderate antinociceptive activity.ConclusionSesquiterpenes lactones (STLs) are widely present in numerous genera of the family Asteraceae (compositae). They are described as the active constituents used in traditional medicine for the treatment of various diseases. The present study reveals the significant potentials of STL and may be used as an alternative for the management of cancer. Anyhow, the isolated compound is having no prominent antinociceptive potentials.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1517-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem

Shoaib

Shah

Ali

et al. 2017

BMC Complement Altern Med

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“…In recent years, anticancer activity of SLs has attracted a great deal of interest, and extensive researches have been carried out to illuminate their anticancer properties (S. Zhang, Won, Ong, & Shen, ). SLs have a variety of biological activities in inhibiting proliferation, migration, invasion, and inducing apoptosis in different types of cancer cells, such as lung cancer, breast cancer, leukaemia, and colorectal cancer (Cotugno et al, ; Fang et al, ; Lee, Hwangbo, Lee, Seo, & Lee, ; Rasul et al, ). However, the intracellular molecular targets of SLs have not been well elucidated, and continued work is needed to identify the mechanisms of SLs in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

“…have a variety of biological activities in inhibiting proliferation, migration, invasion, and inducing apoptosis in different types of cancer cells, such as lung cancer, breast cancer, leukaemia, and colorectal cancer (Cotugno et al, 2012;Fang et al, 2010;Lee, Hwangbo, Lee, Seo, & Lee, 2010;Rasul et al, 2013). However, the intracellular molecular targets of SLs have not been well elucidated, and continued work is needed to identify the mechanisms of SLs in cancer therapy.…”

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confidence: 99%

F1012‐2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy

Tian

Yan

Yang

et al. 2018

Phytotherapy Research

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Sesquiterpene lactones (SLs) are plant-derived constituents that have been proved to have potential antitumour activity. However, the intracellular molecular targets of SLs and the underlying molecular mechanisms have not been well elucidated. Here, we report that F1012-2, a novel SL active fraction, isolated from Eupatorium lindleyanum DC., can significantly inhibit the growth of triple-negative breast cancer (TNBC) cells (MDA-MB-231 and MDA-MB-468) but has no obvious inhibitory effect on the growth of human mammary epithelial cells (MCF-10A). The related mechanisms on cell growth inhibition of F1012-2 were demonstrated by inducing apoptosis in a caspase-dependent manner through the intrinsic pathway and extrinsic pathway. F1012-2 could also activate autophagy in TNBC cells. Simultaneously, we found that F1012-2-induced apoptosis was enhanced by inhibition of autophagy. Furthermore, F1012-2 could induce cell cycle arrest at G2/M phase with decreasing expression of cyclin B1, cdc2, and upregulating p21, p-cdc2. Also, F1012-2 activated Akt and p38 signalling pathways. In vivo, F1012-2 exhibited a potential antitumour effect in MDA-MB-231 xenografts without apparent toxicity. Taken together, our results identified that F1012-2 inhibited cell growth via multiple signalling pathways in vitro and in vivo. These data suggest that F1012-2 may be a potential natural active fraction for the treatment of TNBC.

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“…They employ it to treat injuries and gastrointestinal disorders. A recent study detected that the sesquiterpene of the plant is active against leukemia (Cotugno et al, 2012). Rue (Ruta graveolens L., Family Rutaceae), eucalyptus (Eucalyptus obliqua, Family Myrtaceae) and plantain (Plantago major, Family Plantaginaceae) presented a similar percentage of frequency (31-33%).…”

Section: Resultsmentioning

confidence: 61%

Medicinal Plants Used in Traditional Herbal Medicine in the Province of Chimborazo, Ecuador

Morales¹,

Padilla²,

Falconí³

2016

AJTCAM

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Background: Phyto-therapy studies on Chimborazo province in Ecuador are really limited. This area, located within the Andes, is considered a millenarian and intercultural province, where multiples cultures and ethnic groups coexist. Materials and Methods: The study was conducted through direct interviews with 84 ancestral healers from the Province of Chimborazo, Ecuador. Results: We presented ten most used species by ancestral healers of Chimborazo province to cure different illnesses and their medicinal uses. We also provided the application mode and some features of healing that should be emphasized. Conclusion:The nettle was the medicinal plant employed for more different illness and the chamomile was the one with higher prevalence. We could confirm that the Native Ecuadorians have a vast variety of traditions and popular medicinal practices that have great value and are needed to be researched and studied extensively.

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Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type‐specific induction of apoptosis and mitotic catastrophe

Cited by 37 publications

References 55 publications

Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem

Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem

F1012‐2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy

Medicinal Plants Used in Traditional Herbal Medicine in the Province of Chimborazo, Ecuador

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