Effect of Shenfu injection on lipopolysaccharide (LPS)-induced septic shock in rabbits

Xi, Lifeng; Liu, Runzhe; Dai, Zhenfeng; Wu, Hao; Lin, Mingxiang; Fang, Tian; Gao, Ze-yu; Zhao, Xin; Sun, Yi; Pu, Xiaoping

doi:10.1016/j.jep.2019.01.008

Cited by 24 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the corresponding liver cells are damaged, the permeability of the cell membrane increases and the AST in the cytoplasm is released into the blood, so the serum concentration of AST can be increased [35]. CREA is mainly excreted by glomerular filtration and its abnormal blood content indicates kidney damage in aging mice [36]. CK is mostly in the cytoplasm and mitochondria of myocardium, and is an important kinase that is directly related to intracellular energy movement, muscle contraction, and ATP regeneration, which are related to aging.…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

Zhao

Gao

et al. 2019

Molecules

View full text Add to dashboard Cite

The present work mainly describes the preparation of acetylated mycelia polysaccharides (AMPS) from Pleurotus djamor and investigates the antioxidant and anti-aging effects in d-galactose-induced aging mice. The optimized procedure indicates the acetyl substitution degree of AMPS is 0.54 ± 0.04 under the conditions of a reaction time of 56 h, a reaction temperature of 37 °C, and 4 mL of added acetic anhydride. The in vitro analysis and in vivo animal experiments indicate that the AMPS could alleviate the aging properties by scavenging the radicals, elevating the enzyme activities, and reducing the lipid contents. As for serum levels, the AMPS can improve the serum biochemical indices and enhance immunological activity. The histopathological observations indicate that the injuries to the liver, kidney, and brain can be remitted by AMPS intervention. The characterization showed that AMPS was one kind of β-pyranose with the weight-average molecular weights of 3.61 × 105 Da and the major monosaccharides of mannose and glucose. The results suggest that AMPS can be used as a dietary supplement and functional food for the prevention of aging and age-related diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

Zhao

Gao

et al. 2019

Molecules

View full text Add to dashboard Cite

show abstract

“…In addition, SFI increased levels of adenosine triphosphate (ATP) and taurine in the heart, while reducing the level of adenosine monophosphate (AMP) in the heart. The results showed that SFI had a significant protective effect against LPS-induced septic shock (Liu et al, 2019b).…”

Section: Progress Of Pharmacological Research On Sfimentioning

confidence: 93%

“…Anti-shock Increases content of ATP and taurine, and reduces content of AMP in the heart (Liu et al, 2019b).…”

Section: Sepsismentioning

confidence: 99%

Chinese Patent Medicines in the Treatment of Coronavirus Disease 2019 (COVID-19) in China

et al. 2020

View full text Add to dashboard Cite

Background: Coronavirus Disease 2019 (COVID-19) is an emerging and rapidly evolving disease, with no recommended effective anti-coronavirus drug treatment. Traditional Chinese Patent Medicines (CPMs) have, however, been widely used to treat COVID-19 in China, and a number of clinical practice results have shown them to have a significant role in its treatment. Consequently, numerous guidelines and expert consensus have recommended the use of CPMs to treat COVID-19. Aim of the Study: The objectives of this review are to provide up-to-date information on the pharmacology and clinical research on CPMs in the treatment of COVID-19, discuss the research findings, and to better guide clinical application and scientific research on CPMs in the treatment of COVID-19. Methods: The frequencies of CPM recommendations by guidelines and expert consensus for treatment of COVID-19 in China were ranked. This report identifies the top 10 CPMs, which include Huoxiang Zhengqi capsule (HXZQC), Lianhua Qingwen capsule (LHQWC), Jinhua Qinggan granule (JHQGG), Shufeng Jiedu capsule (SFJDC), Tanreqing injection (TRQI), Xiyanping injection (XYPI), Xuebijing injection (XBJI), Shenfu injection (SFI), Shengmai injection (SMI), and Angong Niuhuang pill (AGNHP). Relevant studies from 2000 to 2020 on these top 10 CPMs, covering usage, dosage, mechanism, curative effect, and precautions, were collected from pharmacopoeia, reports, and theses via library and digital databases (including PubMed, CNKI, Google Scholar, Web of Science, and Elsevier). Results: The properties of the top 10 CPMs included antiviral, antibacterial, antiinflammatory, antipyretic and analgesic, anti-acute lung injury, anti-shock, immune regulation, and enhancement of pulmonary function. In addition, clinical research results and Chinese treatment data showed that the CPMs had good therapeutic efficacy in the treatment of COVID-19, and adverse reactions were minimal.

show abstract

“…Three ginseng containing formulations, Shenfu Injection, Shengmai Injection and Shenmai Injection had similar therapeutic effects of tonifying Qi and preventing exhaustion, they could be adjuvant rescue and alternative treatment of COVID-19 patients with septic shock, viral myocarditis, and cardiogenic shock in clinical practice [91][92][93]. For example, in rabbits with LPS-induced septic shock, Shenfu injection could increase mean arterial pressure, decrease the serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and glutamate transaminase (ALT) levels, improve the tissue morphology of heart, liver and kidney, and increase the contents of ATP and taurine in the heart tissue during septic shock [94]. Besides, previous studies demonstrated that Shenfu Injection, Shengmai Injection and Shenmai Injection were associated with protective effects on lung ischemia-reperfusion injury, reducing chemotherapy-induced adverse effects, and promoting cellular immunity and cognitive dysfunction and so on, presumably, these clinical functions might improve symptoms of critical patients with COVID-19 in terms of lung inflammation, virus infection, drug-induced disease lung injury [95][96][97][98].…”

Section: Only Adjuvant Rescue For Critical Infectionmentioning

confidence: 99%

The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence

Zhang

et al. 2020

Pharmacological Research

View full text Add to dashboard Cite

The outbreak of emerging infectious pneumonia caused by 2019 Novel Coronavirus (2019-nCoV) has posed an enormous threat to public health, and traditional Chinese medicine (TCM) have made vast contribution to the prevention, treatment and rehabilitation of coronavirus disease 19 (COVID-19) among Chinese population. As an indispensable part of TCM, Chinese patent medicines (CPMs) are highly valued and critically acclaimed in their campaign to contain and tackle the epidemic, they can achieve considerable effects for both suspected cases under medical observation period, and confirmed individuals with serious underlying diseases or critical conditions. Given this, based on the Guideline on Diagnosis and Treatment of Coronavirus Disease 2019 in China, the present review summarized the basic information, clinical evidence and published literatures of recommended CPMs against COVID-19. The details were thoroughly introduced involving compositions, therapeutic effects, clinical indications, medication history of CPMs and the profiles of corresponding research. With regard to infected patients with different stages and syndrome, the preferable potentials and therapeutic mechanism of CPMs were addressed through the comprehensive collection of relevant literatures and ongoing clinical trials. This study could provide an insight into clinical application and underlying mechanism of recommended CPMs against COVID-19, with the aim to share the Chinese experience in clinical practice and facilitate scientific development of TCM, especially CPMs in the fierce battle of COVID-19. million confirmed cases with COVID-19 worldwide, of these, a total of 277,965 subjects were from the United States [13,14]. According to official release on April 4, 2020 by National Health Commission of the People's Republic of China, more than 80,000 cases had been confirmed as COVID-19 with 3326 death cases [15]. Currently, the global pandemic of COVID-19 continues to accelerate and escalate, the health-care systems of different countries are beavering away to contain the virus, therefore, there is urgent need to seek for effective or adjuvant therapies with excellent safety profiles against COVID-19 [16-18]. In the theory of traditional Chinese medicine (TCM), 2019-nCoV infected pneumonia was deemed to the category of "Pestilence", and the characteristics of its pathogenesis was "dampness, toxin, stasis and closure" [19,20]. Over the past few months, TCM exhibited remarkable benefits against COVID-19 in China, and it was convinced that TCM achieved satisfactory therapeutic superiority for patients infected by 2019-nCoV with regard to preventive treatment of diseases, comprehensive therapies and rehabilitation by the

show abstract

Effect of Shenfu injection on lipopolysaccharide (LPS)-induced septic shock in rabbits

Cited by 24 publications

References 33 publications

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

Chinese Patent Medicines in the Treatment of Coronavirus Disease 2019 (COVID-19) in China

The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence

Contact Info

Product

Resources

About