Effect of silver and fluoride ions on enamel demineralization: a quantitative study using micro‐computed tomography

Liu, B Y; Lo, Edward Chin Man; Li, C M T

doi:10.1111/j.1834-7819.2011.01641.x

Cited by 53 publications

(54 citation statements)

References 23 publications

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“…However, the differences in efficacy were not obvious, despite the 5 times difference in fluoride concentration. It should be noted that the high Ag concentration (24%) in the SDF solution was not responsible for the anti-demineralization effect as a previous study reported almost complete inhibition of enamel demineralization using 2.36 M AgF (25.5% Ag, 44,840 ppm F) or KF (44,840 ppm F), but no significant difference between 2.36 M AgNO 3 and the untreated (control) groups was observed 27) . An overall finding indicated that the antidemineralization efficacy was ranked in the order of SDF≑KF>ZnF 2/HCl>APF>ZnF2.…”

Section: Discussionmentioning

confidence: 98%

Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents

et al. 2016

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Root caries is developed because of demineralization followed by enzymatic collagen degradation. This in vitro study aimed to examine the inhibitory efficacy of ZnF2 on dentin demineralization and collagen degradation. Bovine dentin specimens were treated either with ZnF2 or HCl-acidified ZnF2 (ZnF2/HCl) and then demineralized. Anti-demineralization efficacy was assessed by TMR as mineral loss (ΔZ). The efficacy was compared with silver diammine fluoride (SDF), KF, and acidulated phosphate fluoride (APF). For evaluating anti-collagen degradation, EDTA-demineralized dentin specimens were treated by one of four fluoride agents [SDF, APF, ZnF2/HCl, NaF] followed by collagenase challenge. The eroded depth of collagen layer in the lesion was assessed using optical microscope. ΔZ of SDF, KF, ZnF2/HCl, and APF were significantly lower compared with ZnF2 and Control (no treatment). Regarding anti-collagen degradation, SDF and ZnF2/HCl demonstrated a significant difference in the eroded depth compared with Control. Although SDF possessed higher efficacy, ZnF2/HCl might be beneficial as a staining-free agent.

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Section: Discussionmentioning

confidence: 98%

Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents

et al. 2016

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“…Fluoride is available in a variety of dosage forms including sodium diamine fluoride (SDF), nanosilver fluoride (NSF), and propolis fluoride (PPF) [4][5][6][7][8][9][10][11][12][13][14]. Previous studies using SDF have shown that SDF consists of silver (Ag) and fluoride (F); silver acts as an antimicrobial agent and fluoride plays a role in enhancing remineralization as a strong anticaries agent [11].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Several Fluoride-Based Varnishes as Remineralization Agents: Morphological Studies, Dentin Surface Hardness, and Crystallinity Tests

et al. 2018

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Objectives:This study was conducted to analyze the effects of several fluoride-based varnishes: Sodium diamine fluoride (SDF), nanosilver fluoride (NSF), and propolis fluoride (PPF). Fluoride-based varnish is proven to remineralize and arrest caries progression with minimal side effects. SDF, the gold standard for this study, compared to NSF and PPF to observe the dentin morphology, hardness, and crystallinity test.Methods: Dentin blocks were allocated and divided into control groups and treatment groups with SDF (38%), NSF (3.16%, 3.66%, and 4.16%), and PPF (3%, 6%, and 10%). The dentin discs were demineralized using a demineralization solution (pH 4.4) for 96 h. Each dentin disc in the treatment group received a topical application of various fluoride-based varnishes and was then subjected to pH cycling for 8 days. The surface morphology of dentin was observed by a scanning electron micrograph (SEM), dentin hardness was analyzed by a Vickers microhardness tester, and the crystal characteristics of dentin blocks were investigated by X-ray diffraction (XRD). Results:This study showed crystal fluorapatite on the dentin surface of SDF and NSF. There was an amorphous layer on the dentin surface of PPF (10%) detected when using SEM. The Vickers hardness number of dentin increased after the application of SDF, NSF, and PPF. XRD revealed precipitates of apatite compounds, calcium compounds, and metal compounds in the treatment groups in higher concentrations than in the control (demineralized) group. Conclusion:It was concluded that SDF, NSF, and PPF were effective for dentin remineralization. Hence, NSF and PPF fluoride-based varnishes are promising as anticariogenic agents.

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“…Moreover, there is a technical problem with the method used in this study when assessing lesions in pit and fissure areas because they have irregular surface borders. 17 The difficulties lie in drawing the region of interest properly and in measuring the path length of the irregular lesion surface border accurately. 17 Nonetheless, the data from the present study clearly showed that micro-CT offers a reproducible, noninvasive technique for the 3D assessment of demineralization and remineralization of dental enamel.…”

Section: Discussionmentioning

confidence: 99%

“…17 The difficulties lie in drawing the region of interest properly and in measuring the path length of the irregular lesion surface border accurately. 17 Nonetheless, the data from the present study clearly showed that micro-CT offers a reproducible, noninvasive technique for the 3D assessment of demineralization and remineralization of dental enamel. Because micro-CT is nondestructive approach, it is possible to analyze the mineralization of dental enamel before, during and after pH cycling.…”

Section: Discussionmentioning

confidence: 99%

“…An unvarnished occlusal surface window was created for each of these 40 tooth blocks by covering each occlusal surface with a 3x5 mm 2 sticker and painting all other surfaces with an acid-resistant varnish. 17 These blocks were randomly allocated into four groups that were immersed in remineralizing solutions for 26 minutes at 37°C: Group A, milk; Group B, milk and tea; Group C, milk and 0.2% NaF; and Group D, deionized water (control). Next, the tooth blocks were immersed in a buffered demineralization solution at pH 4.4 for 3 days.…”

Section: Methodsmentioning

confidence: 99%

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The Effect of Milk or its Combination with Tea and 0.2% NaF on Dental Enamel Demineralization Analyzed by Micro Computed Tomography

Rahardjo¹,

Sahertian²,

Ramadhani³

et al. 2014

J Dent Indones

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Fluoride and calcium play an important role in the prevention of dental caries, promoting the inhibition of demineralization and the increase of remineralization. Objective: To investigate the effects of milk with/without the combination of tea and 0.2% NaF on enamel demineralization using micro-computed tomography (micro-CT). Methods: The coronal parts of 40 extracted sound premolars were prepared as tooth blocks. An unvarnished occlusal surface window was created for each tooth by covering the occlusal surface with a 3x5 mm 2 sticker and painting all other surfaces with an acid-resistant varnish. These blocks were randomly allocated into four groups that were immersed in remineralizing solutions for 26 minutes: Group A, milk; Group B, milk and tea; Group C, milk and 0.2% NaF; and Group D, deionized water (control). Results: After 3 days of immersion in a buffered demineralization solution at pH 4.4, micro-CT scans were taken. The mean grayscale values and the standard deviations are: 98.1 ± 24.0; 90.8 ± 9.1; 92.6 ± 21.4; 81.1 ± 20.3, respectively. The mean grayscale values were significantly different among the four groups (p<0.05), except between groups A and B and between groups A and C. Conclusion: Topical application with milk alone showed a higher protective effect against demineralization compared to the synergic application of milk and tea and milk and 0.2% NaF. ABSTRAKEfek susu, kombinasinya dengan teh, dan NaF 0,2% terhadap demineralisasi email gigi: analisis microcomputed tomography. Fluor dan kalsium berperan penting dalam pencegahan karies gigi, karena dapat menghambat demineralisasi dan meningkatkan remineralisasi Tujuan: Menganalisis efek dari susu sendiri dan kombinasi dengan teh, dan NaF 0,2% pada demineralisasi email gigi menggunakan micro-computed tomography (micro-CT). Metode: Pada bagian koronal 40 gigi premolar manusia yang telah diekstraksi, dibuatkan region of interest. Permukaan oklusal tiap gigi tersebut ditutupi stiker 3x5 mm 2 dan semua permukaan lainnya ditutupi dengan pernis tahan asam. Gigi-gigi yang telah dipersiapkan ini secara acak dan dialokasikan ke dalam empat kelompok yang direndam dalam larutan remineralisasi selama 26 menit, yakni: Grup A, susu; Grup B, susu dan teh; Grup C, susu dan NaF 0,2%; dan Grup D, deionized air (kontrol). Hasil: Setelah 3 hari perendaman dalam larutan buffer pada pH 4,4, dilakukan pemindaian dengan micro-CT. Nilai rata-rata grayscale dan standar deviasi secara berurutan: 98,1 ± 24,0; 90,8 ± 9,1; 92,6 ± 21,4; 81,1 ± 20,3. Nilai rata-rata grayscale yang berbeda bermakna secara signifikan antara empat kelompok tersebut (p<0,05), kecuali antara kelompok A dan B dan antara kelompok A dan C. Simpulan: Topikal aplikasi dengan susu saja menunjukkan efek perlindungan yang lebih tinggi terhadap demineralisasi dibandingkan dengan aplikasi sinergis susu dengan teh dan, susu dengan, 0,2% NaF.

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Effect of silver and fluoride ions on enamel demineralization: a quantitative study using micro‐computed tomography

Cited by 53 publications

References 23 publications

Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents

Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents

The Potential of Several Fluoride-Based Varnishes as Remineralization Agents: Morphological Studies, Dentin Surface Hardness, and Crystallinity Tests

The Effect of Milk or its Combination with Tea and 0.2% NaF on Dental Enamel Demineralization Analyzed by Micro Computed Tomography

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