Effect of silver nanoparticles (AgNPs) exposure on microRNA expression and global DNA methylation in endothelial cells EA.hy926

González-Palomo, Ana Karen; Saldaña-Villanueva, Kelvin; Cortés-García, Juan D.; Fernández-Macías, Juan Carlos; Méndez-Rodríguez, Karen Beatriz; Maldonado, Iván Nelinho Pérez

doi:10.1016/j.etap.2020.103543

Cited by 13 publications

(8 citation statements)

References 77 publications

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“…Nanodiamond (ND) induced abnormal upregulation of DNMT2 in human cervical carcinoma (HeLa) cells and increased overall DNA methylation (Mytych et al, 2014). Exposure of nerve cells and endothelial cells to AgNPs could stimulate DNA methylation as well as the expression of DNMTs, suggesting that the potential toxicity of NMs should not be ignored when applied in nanomedicines (Gonzalez‐Palomo et al, 2021; Mytych et al, 2017).…”

Section: Dna Methylationmentioning

confidence: 99%

“…Human umbilical vein endothelial cells (HUVECs) exposed to SiNPs (58.11 ± 7.30 nm) were found to negatively regulate IL6R/STAT/TF signaling pathway via miR‐451a, which had the potential to induce thrombosis by causing vascular endothelial dysfunction (Feng et al, 2019). Alternatively, Maldonado et al detected decreased miRNA‐126, 146, and 155 expression levels in endothelial cells exposed to AgNPs, and also found that elevated expression of vascular cell adhesion molecule‐1 (VCAM‐1) and interleukin 6 (IL‐6), the target genes of these miRNAs, caused inflammatory responses (Gonzalez‐Palomo et al, 2021). The above results suggested that exposure to NMs could induce cardiovascular disease and that miRNAs play a regulatory role in this process.…”

Section: Noncoding Rnamentioning

confidence: 99%

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The critical role of epigenetic mechanisms involved in nanotoxicology

Sun

et al. 2022

WIREs Nanomed Nanobiotechnol

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Over the past decades, nanomaterials (NMs) have been widely applied in the cosmetic, food, engineering, and medical fields. Along with the prevalence of NMs, the toxicological characteristics exhibited by these materials on health and the environment have gradually attracted attentions. A growing number of evidences have indicated that epigenetics holds an essential role in the onset and development of various diseases. NMs could cause epigenetic alterations such as DNA methylation, noncoding RNA (ncRNA) expression, and histone modifications. NMs might alternate either global DNA methylation or the methylation of specific genes to affect the biological function. Abnormal upregulation or downregulation of ncRNAs might also be a potential mechanism for the toxic effects caused by NMs. In parallel, the phosphorylation, acetylation, and methylation of histones also take an important part in the process of NMs‐induced toxicity. As the adverse effects of NMs continue to be explored, mechanisms such as chromosomal remodeling, genomic imprinting, and m6A modification are also gradually coming into the limelight. Since the epigenetic alterations often occur in the early development of diseases, thus the relevant studies not only provide insight into the pathogenesis of diseases, but also screen for the prospective biomarkers for early diagnosis and prevention. This review summarizes the epigenetic alterations elicited by NMs, hoping to provide a clue for nanotoxicity studies and security evaluation of NMs. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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Section: Dna Methylationmentioning

confidence: 99%

Section: Noncoding Rnamentioning

confidence: 99%

The critical role of epigenetic mechanisms involved in nanotoxicology

Sun

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…75,150 A variety of nanoparticles including gold and silver have been shown to enhance angiogenesis, possibly through the modulation of reactive oxygen species. [151][152][153] When testing the ability of biomaterials to regenerate bone, one can make changes in multiple properties, but the behavior of cells important for bone formation, bone resorption, vascularization, and the immune response need to be studied in order to more accurately predict the outcomes in vivo or in clinical trials, as osteoblasts are not the only cell type that instruct healthy bone formation.…”

Section: Balancing Multiple Cell Types and Interactionsmentioning

confidence: 99%

Biomaterial design strategies to address obstacles in craniomaxillofacial bone repair

Dewey

Harley

2021

RSC Adv.

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“…There are extensive studies which investigated the toxicity of metal particles to ECs (C. M. Chen et al, 2020; Duan et al, 2014; Gholinejad et al, 2019; Gonzalez‐Palomo et al, 2021; Guo et al, 2018; Guo et al, 2016; Khan et al, 2019; Lee et al, 2019; Liang et al, 2020; Liang et al, 2016; X. Liu et al, 2021; Poier et al, 2020; Shi et al, 2014; D. P. Wang et al, 2020; W. Wang et al, 2018; Yan et al, 2020; Zeng et al, 2018). Numerous studies have reported that silica NPs (Si NPs) can induced apoptosis, autophagy, inflammation and oxidative stress through multiple signaling pathways, which in turn trigger vascular endothelial cell injury (Duan et al, 2014; Guo et al, 2018; Guo et al, 2016; Lee et al, 2019; X. Liu et al, 2021; D. P. Wang et al, 2020; W. Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…But Si NPs modified with polyethylene glycol could significantly alleviate the vascular endothelial damage (Liang et al, 2020). Silver NPs (Ag NPs) could affect the function of ECs through various passages (Gonzalez‐Palomo et al, 2021; Khan et al, 2019; Shi et al, 2014). And, zinc oxide NPs (ZnO NPs) have been reported to cause damage in ECs (C. M. Chen et al, 2020; Liang et al, 2016; Poier et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The effect of nanoparticles of cobalt–chromium on human aortic endothelial cells in vitro

Zhu

Zhang

Liu

et al. 2021

J of Applied Toxicology

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Despite advances in stent technology for vascular interventions, in‐stent restenosis (ISR) remains a main complication. The corrosion of cobalt–chromium (CoCr) alloy coronary stents has been identified to be associated with ISR, whereas its role in ISR has not been elucidated. In the current work, CoCr nanoparticles, simulated corrosion products of CoCr alloy, were used to investigate their effect on the endothelial cells. It has been demonstrated that the cell viability declines and the cell membrane is damaged, indicating the cytotoxicity of CoCr nanoparticles. The expression of GRP78, CHOP, and cleaved‐caspase12 proteins has increased when exposed to CoCr nanoparticles, suggesting that CoCr nanoparticles induced cell apoptosis through endoplasmic reticulum (ER) stress‐mediated apoptotic pathway. An increased release of adhesion and inflammatory mediators was also induced by CoCr nanoparticles, including ICAM‐1, VCAM‐1, IL‐1β, IL‐6, and TNF‐α. Our results demonstrated that CoCr nanoparticles could trigger apoptosis, adhesion, and inflammation. These findings indicated potential damaging effects of CoCr nanoparticles on the vascular endothelium, which suggested corrosion of CoCr alloy may promote the progression and development of ISR.

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Effect of silver nanoparticles (AgNPs) exposure on microRNA expression and global DNA methylation in endothelial cells EA.hy926

Cited by 13 publications

References 77 publications

The critical role of epigenetic mechanisms involved in nanotoxicology

The critical role of epigenetic mechanisms involved in nanotoxicology

Biomaterial design strategies to address obstacles in craniomaxillofacial bone repair

The effect of nanoparticles of cobalt–chromium on human aortic endothelial cells in vitro

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