The aim of this study was to detect the pathological affections in various body organs in dead animals by foot and mouth disease (FMD) throughout Kaluobia Governorate, Egypt. The study included 882 clinically affected animals showing characteristic signs of foot and mouth disease including, 827 cattle, and 55 buffalo. The age of the examined animals ranged from 30 days to 3 years and they were of both sexes. The total mortality rates were 6.65% in cattle and 54% in buffalos. The most common clinical signs that appeared on examined cases represented by fever, depression, recumbency, lameness, ropy salivation, ptyalism with protrusion of the tongue. Moreover, in young calf's sudden death was the only observed clinical signs. Histopathological examination of both young calves (1-2 months old) and aged calves (12-24 months old), revealed extensive inflammatory and necrotic lesions in the myocardium, lung, liver, kidney, spleen and intestine. Viral isolation from tongue epithelium and molecular identification revealed the presence of FMD virus 'type O'.