Effect of Some Synthesized Pyrrolidines in Growth of L. infantum Promastigotes

Abstract

In this research, three pyrrolidine compounds (P1-P3) were synthesized and then tested for efficacy against L. infantum promastigotes in vitro.
 The study included preparation of some chalcones and schiff bases then the condensation of both to get the pyrrolidines and studying the effect of pyrrolidine compounds in growth, generation number and time of parasites. They determined using concentrations between (5-30) μg/ml. The effect of the compounds was found to be important to the parasite growth as the more the concentration the less the growth, generation number and increased the generation time. At the logarithmic phase, the LD50 were (10), (20) and (30)μg/ml for (P1-P3) compounds, respectively.