Effect of static magnetic field on bone and its molecular mechanism

Yang, Juhua; Zhang, Hao; Shang, Peng

doi:10.1360/tb-2019-0888

Cited by 6 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a noninvasive physical factor, clinical and animal studies showed that static magnetic fields (SMFs) have beneficial effects on osteoporosis, the nonunion of fractures, bone defect repair, and osteoarthritis. At the cellular level, SMFs promote the activity of osteoblasts and inhibit the differentiation of osteoclasts [ 6 ]. In recent years, an increasing number of studies have found that a combination of SMFs and IONPs is more effective than IONPs alone in promoting osteoblast differentiation and inhibiting osteoclast formation [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Yang

Guo

et al. 2022

Cells

View full text Add to dashboard Cite

Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fields (SMFs) were also found to enhance osteoblast differentiation and hinder osteoclastic differentiation. Once IONPs are exposed to an SMF, they become rapidly magnetized. IONPs and SMFs work together to synergistically enhance the effectiveness of their individual effects on the differentiation and function of osteoblasts and osteoclasts. This article reviewed the individual and combined effects of different types of IONPs and different intensities of SMFs on bone remodeling. We also discussed the mechanism underlying the synergistic effects of IONPs and SMFs on bone remodeling.

show abstract

Section: Introductionmentioning

confidence: 99%

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Yang

Guo

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…It is well known that various cells, such as mesenchymal stem cells, osteoblasts, and endothelial cells are magnetically sensitive due to the diamagnetism of cell membranes [ 43 ]. Inspired by these, researchers have applied different external magnetic fields to study the roles of magnetic stimulation in bone repair in recent years [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Shuai

Chen

et al. 2022

Biomater Res

View full text Add to dashboard Cite

Background Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. Results The results show that the Fe3O4@SiO2 nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair.

show abstract

“…It is well known that various cells, such as mesenchymal stem cells, osteoblasts, and endothelial cells are magnetically sensitive due to the diamagnetism of cell membranes [45]. Inspired by these, researchers have applied different external magnetic elds to study the roles of magnetic stimulation in bone repair in recent years [46,47].…”

Section: Discussionmentioning

confidence: 99%

Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Shuai

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods: In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology.Results: The results show that the Fe3O4@SiO2 nanochains with unique core-shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion: In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair.

show abstract

Effect of static magnetic field on bone and its molecular mechanism

Cited by 6 publications

References 38 publications

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Contact Info

Product

Resources

About