Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues

Öztürk, Bahadır; Durak, Zahide Esra; Büber, Süleyman; Kocaoğlu, Ender Hilmi

doi:10.1155/2016/8608462

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…Sirmatel et al found after 1.5 T SMF exposure, total antioxidant capacity (TAC) increased significantly in 33 male volunteers [ 39 ]. Along with the increase in total antioxidant capacity, the level of lipid peroxidation was reduced ( Figure 5 F) in mice, which was consistent with Öztürk’s study, which also found that MDA levels were reduced after 60 min, 100 mT SMF exposure in 24 non-cancerous adjacent gastric tissues [ 40 ].…”

Section: Discussionsupporting

confidence: 87%

The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice

Yang

Chen

et al. 2022

Biology

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Because of the high cost and safety of ultra-high magnetic resonance imaging (MRI), its application has certain limitations. Whereas 0.5–3 T MRI has been widely applied in hospitals, static magnetic fields (SMFs) have been shown to improve mice mental health and have anti-tumor potentials. Here, we compared the effects of the upward and downward 150 mT SMF groups with the sham group on C57BL/6J adult female mice. Locomotor and exploratory activity were also measured by behavioral tests, including the open field and elevated plus test. Additionally, physiology, pathology indicators and gut microbiota were examined. We found that 150 mT SMFs long-term exposure enhanced locomotive and exploratory activity of mice, especially the downward 150 mT SMF. Compared with the downward 150 mT SMF group, the movement speed and distance in the center area of the sham group were increased by 65.99% (p < 0.0001) and 68.58% (p = 0.0038), respectively. Moreover, compared to the sham group, downward 150 mT SMF increased the number of entrances to the center area by 67.0% (p = 0.0082) and time in the center area by 77.12% (p = 0.0054). Additionally, we observed that upward 150 mT SMF improved the number of follicles (~2.5 times, p = 0.0325) and uterine glands through increasing the total antioxidant capacity and reducing lipid peroxidation level in mice. Gut microbiome analysis showed that 150 mT SMFs long-term exposure improved the microbiota abundance (Clostridium, Bifidobacterium, Ralstonia and Yaniella) in the genus level, which may affect metabolism, anxiety and behavior in adult female mice. Our results demonstrated that 150 mT SMFs long-term exposure not only had good biosafety, but also improved athletic performance, emotion and the function of ovarian, uterine and gut microbiota abundance in adult female mice, which unraveled the potential of moderate long-term SMF exposure in clinical applications.

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Section: Discussionsupporting

confidence: 87%

The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice

Yang

Chen

et al. 2022

Biology

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“…Öztürk et al 21 compared 24 cancerous gastric tissues to the same number of non-cancerous tissues also taken from the stomach. The material was obtained during surgical operations.…”

Section: Discussionmentioning

confidence: 99%

The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study

Cecerska-Heryć,

Gliźniewicz,

Grygorcewicz

et al. 2024

Sci Rep

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Oxidative stress is characterized by an excessive concentration of reactive oxygen species (ROS) resulting from a disturbance in the balance between ROS production and their removal by antioxidant systems (SOD, CAT, GPx). Prolonged and intense oxidative stress can cause various forms of damage to cells, which markers are total antioxidant capacity (TAC), reactive oxygen species modulator (ROMO1), and malondialdehyde (MDA). It has been demonstrated that magnetic fields can positively affect human health, for example, by reducing oxidative stress. Determination of the effect of a rotating magnetic field (RMF) on the activity/concentration of selected oxidative stress markers. A group of 30 healthy volunteers (15 women and 15 men) (mean age 24.8 ± 5.1) in the study classified into the following groups: internal control group (CG);1 h 25 Hz (samples placed in the field for one hour at 25 Hz); 3 h 25 Hz (samples placed in the field for 3 h at 25 Hz), the 1 h 50 Hz group ( placed in RMF for an hour at 50 Hz), and a group of 3 h 50 Hz (samples placed in the field for 3 h at 50 Hz). Serum samples were collected in K2EDTA tubes.. The magnetic induction value obtained for RMF is 37.06 mT and 42.64 mT.Activity/concentration of selected oxidative stress markers was analyzed by ELISA. The influence of an RMF on the activity/concentration of SOD, MDA, TAC, and ROMO1 was demonstrated (p < 0.001; p = 0.0013; p < 0.001; p = 0.003). The RFM can reduce oxidative stress, as evidenced by higher SOD and CAT activities in the CG than in samples placed in the RFM. Prolonged exposure to the RFM at 50 Hz increased the TAC level, indicating an intensification of oxidative stress in these samples. The optimal conditions for staying in the RFM (reducing oxidative stress) are 1 h 50 Hz for SOD and MDA; 3 h 25 Hz for CAT and TAC. In the case of ROMO1, it is stated that 1 h 25 Hz are the optimal conditions for no increased production of ROS.

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“…A change in ion balance caused by a magnetic field may thus affect DNA synthesis (25). Exposure of gastric cancer to a static magnetic field increased superoxide dismutase (SOD) activity in the cells (26). Similarly, the proliferation of fibroblasts in bleomycin-induced pulmonary fibrosis is thought to be due to increased release of PDGF-A from alveolar macrophages.…”

Section: Discussionmentioning

confidence: 99%

A static magnetic field inhibits the expression of platelet-derived growth factor-AA in human oral squamous cell carcinoma

et al. 2018

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Magnetic attachments are commonly used for overdentures. The deleterious effects of exposure to magnetic flux on human health have not been substantiated so far; nevertheless, there is a need to understand the extent of magnetic field exposure in the oral area resulting from the use of magnetic attachments. The purpose of this study was to investigate the influence of a magnetic field on oral squamous cell carcinoma. Tumor cells cultured on a magnetic plate were compared with those not cultured on a magnetic plate (controls). The cells were seeded at a density of 1 × 10 cells/well and cultured for 6 days. The influence of the magnetic field on cytokine production was examined by cytokine array analysis. Secretion of platelet-derived growth factor-AA (PDGF-AA) was measured by enzyme-linked immunosorbent assay and Western blotting. The expression of PDGF-AA messenger RNA was examined by real-time polymerase chain reaction, whereas nuclear factor-kappa B activity was measured by luciferase assay. The results indicated that the magnetic field inhibited the secretion of PDGF-AA, thereby inhibiting PDGF-AA-induced expression, thus reducing the risk of cancer recurrence.

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Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues

Cited by 7 publications

References 24 publications

The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice

The Effect of Long-Term Moderate Static Magnetic Field Exposure on Adult Female Mice

The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study

A static magnetic field inhibits the expression of platelet-derived growth factor-AA in human oral squamous cell carcinoma

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