Effect of sugammadex on rocuronium induced changes in pancreatic mast cells

Abstract

Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. The aim of this study was to investigate the effects of sugammadex on pancreatic changes due to rocuronium. A total of 42 Sprague-Dawley male rats were divided into six equal groups to receive either rocuronium 1 mg/kg intravenously (i.v., R group), rocuronium 1 mg/kg + sugammadex 16 mg/kg i.v. (RS16 group), rocuronium 1 mg/kg + sugammadex 96 mg/kg i.v. (RS96 group), sugammadex 16 mg/kg (S16), sugammadex 96 mg/kg i.v. (S96 group), or 0.9% sodium chloride (control group). Sugammadex was administered 5s later following rocuronium. In R group, mast count was higher, and the distribution rate of granules and nuclear changes were different compared with other groups. Distribution rate of granules in groups S16 and S96 were similar to the control group and lower compared with other groups. The amount of mast cells and granule density in groups RS16 and RS96 was lower compared with R group. The amount of mast cells in groups RS16 and RS96 was significantly lower compared with other treatment groups. These results suggest that sugammadex may have an inhibitory effect on mobilization and morphological changes in pancreatic mast cells induced by administration of rocuronium and sugammadex in rats.

Sugammadex: What do we Know and What do we Still Need to Know? A Review of the Recent (2013 to 2014) Literature

“…However, there was also one case of a patient in whom sugammadex was not associated with immediate haemodynamic improvement 24 . A potential inhibitory effect of sugammadex on pancreatic mast cells in rats has also been reported 25 .…”

Does sugammadex suppress allergic inflammation due to rocuronium in animal model of rat?

“…The effects of rocuronium and sugammadex on mast cells and tryptase in liver and pancreas were investigated in rats. 18,19 However, its effects on the lung, one of the important organs affected in anaphylaxis, are unknown. We planned to investigate the changes caused by rocuronium in the lung and the effect of sugammadex on these changes with biochemical, light microscopic, and immunohistochemical parameters on a rat model.…”

Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

“…5,24 It has also been reported that ROS play a key role in decreasing immune system defense. 5,24,25 In addition, intense proinflammatory cytokine release, due to excessive ROS formation, has been reported during MTX treatment for cancer and autoimmune diseases. 5,6,24,25 Accumulation of ROS leads to neutrophil infiltration and proinflammatory cytokine release, which triggers apoptosis.…”

“…5,24,25 In addition, intense proinflammatory cytokine release, due to excessive ROS formation, has been reported during MTX treatment for cancer and autoimmune diseases. 5,6,24,25 Accumulation of ROS leads to neutrophil infiltration and proinflammatory cytokine release, which triggers apoptosis. 5,6,24,25 Methotrexate is used for the treatment of pancreatic cancer, but has been shown to destroy the beta cells of the pancreas, primarily through oxidative stress.…”

“…5,6,24,25 Methotrexate is used for the treatment of pancreatic cancer, but has been shown to destroy the beta cells of the pancreas, primarily through oxidative stress. 5,6,[24][25][26] A decrease in islets of Langerhans insulin and somatostatin-immunopositive cells was shown in this study following the administration of MTX (Fig. 2B, 3B).…”