Effect of sulfated astragalus polysaccharide on cellular infectivity of infectious bursal disease virus

Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast

“…Some scholars reported that the sulfate of achyranthes bidentata polysaccharide is a promising inhibitor of HIV-1 [32], sulfated polysaccharide from Caulerpa racemosa is a selective inhibitor of HSV-1 and HSV-2 [33]. Our previous research also confirmed that sulfated modification could enhance antiviral activity of astragalus polysaccharide and epimedium polysaccharide [21,34].…”

Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit

“…Therefore, they have been widely used in medicine as immunomodulators due to their pharmaceutical therapy character and low toxicity [4,5]. The biological activities of polysaccharides are related to the weight-average molecular weight (Mw), degree of substitution (DS), water solubility and chemical structure of main chain and branches [6][7][8]. Especially, it is found chemical modification of polysaccharides provided a kind of method to obtain new pharmacological agents, lots of the polysaccharides have became antioxidant, anticoagulant, antithrombotic, antiviral and immunomodulatory after they are sulfated [9][10][11].…”

Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities

“…Chemical modification of polysaccharides provided an opportunity to obtain new pharmacological agents with possible therapeutic uses. To our knowledge, there are four main factors influenced the bioactivities of polysaccharides, namely the water solubility, weight-average molecular weight (M w ), chain conformation and introduction of suitable ionic groups with appropriate degree of substitution (DS) [5][6][7]. One water-insoluble polysaccharide from P. tuber-regium was modified by sulfate group exhibited relatively higher in vitro antitumor activity against human hepatic cancer cell line HepG2 than itself.…”