Effect of sulfated galactan from Porphyra haitanensis on H2O2-induced premature senescence in WI-38 cells

Zhang, Zhongshan; Wang, Xiaomei; Su, Huili; Pan, Yuxiang; Han, Jianfang; Zhang, Taisheng; Mao, Genxiang

doi:10.1016/j.ijbiomac.2017.08.123

Cited by 30 publications

(7 citation statements)

References 26 publications

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“…In addition, studies disclosed that red algal polysaccharides can alleviate cell damage and aging [113,114], but the possible protective mechanisms of red algal polysaccharides on cell damage are still unclear. Subsequently, studies revealed that oxidative stress and DNA damage could be relieved by red algal polysaccharides via reducing the activity of SA-β-gal and inhibiting p53-p21 pathways, and ultimately attenuating senescence of WI-38 cells induced by H 2 O 2 [93].…”

Section: Red Algal Polysaccharidesmentioning

confidence: 99%

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

et al. 2019

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Marine-derived antioxidant polysaccharides have aroused extensive attention because of their potential nutritional and therapeutic benefits. However, the comprehensive comparison of identified marine-derived antioxidant polysaccharides is still inaccessible, which would facilitate the discovery of more efficient antioxidants from marine organisms. Thus, this review summarizes the sources, chemical composition, structural characteristics, and antioxidant capacity of marine antioxidant polysaccharides, as well as their protective in vivo effects mediated by antioxidative stress reported in the last few years (2013–2019), and especially highlights the dominant role of marine algae as antioxidant polysaccharide source. In addition, the relationships between the chemical composition and structural characteristics of marine antioxidant polysaccharides with their antioxidant capacity were also discussed. The antioxidant activity was found to be determined by multiple factors, including molecular weight, monosaccharide composition, sulfate position and its degree.

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Section: Red Algal Polysaccharidesmentioning

confidence: 99%

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

et al. 2019

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“…Similarly, a previous study reported that treatment with H 2 O 2 decreased cell survival by 43%, while caffeic acid elicited a cell-protective effect by increasing the cell survival rate [ 32 ]. In another study, treatment with H 2 O 2 was shown to decrease cell viability by up to 70%, which was reversed following administration of porphyrin, which promoted cell viability [ 33 ]. These results indicate that CBV2 protects cells against acute oxidative stress conditions without causing cell toxicity.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Obesity, and Anti-Aging Activities of Jeju Citrus Blended Vinegar

Yun¹,

Park²,

Kim³

et al. 2021

Foods

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Various types of vinegars have been developed as interest in their health benefits has increased. In this study, we prepared Jeju citrus blended vinegars (CBVs) by mixing premature mandarin vinegar and mandarin vinegar, with mandarin vinegar used as a control. The physicochemical properties of the vinegars, including pH, total acidity, and sugar content was determined. Moreover, antioxidant, anti-obesity, and anti-aging activities of the vinegars were investigated. Physicochemical analysis revealed that the CBVs had a pH similar to that of mandarin vinegar, whereas CBVs with relatively high premature mandarin vinegar content showed higher acidity and lower sugar content (p < 0.05). Moreover, the antioxidant activities and phenol contents of CBVs were significantly higher than those of mandarin vinegar (p < 0.05). Meanwhile, CBVs showed significantly decreased intracellular triglyceride, lipid accumulation, and anti-obesity related gene levels (p < 0.05), thereby highlighting their anti-obesity activity. In addition, CBVs showed anti-aging activity by increasing cell viability and cell lifespan, while decreasing the expression of senescence-related genes under H2O2-induced oxidative stress. Therefore, CBVs may be useful as a functional food with antioxidant, anti-obesity, and anti-aging effects in various food fields.

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“…[41] Cell viability It has been reported that cells induced with H 2 O 2 undergo premature senescence. [42] This leads to reduced cell viability and cell damage. It has been previously shown that human embryonic lung diploid fibroblasts cells can be used to establish models of stress-induced premature senescence.…”

Section: Resultsmentioning

confidence: 99%

In vitro antioxidant and anti-aging properties of swim bladder peptides from Atlantic cod (Gadus morhua)

et al. 2020

International Journal of Food Properties

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Two bioactive peptide fractions (SWP-I and SWP-II) of swim bladder peptides from Atlantic cod (Gadus morhua) were obtained through enzymatic hydrolysis and isolated by gel filtration chromatography. The properties of two fractions were characterized by FT-IR, UV scanning spectroscopy, amino acid composition analysis and molecular weight determination. The results showed that the content of aromatic amino acids in SWP-II was higher than that in SWP-I, and the molecular of SWP-I and SWP-II were 4976 Da and 1960 Da, respectively. The radical scavenging activities showed that SWP-I and SWP-II were effective scavengers of DPPH•, HO•, and O 2-•, and demonstrated high Fe 2+-chelating activity. The scavenging capacities of SWP-II were stronger than those of SWP-I at the same concentration. Cytoprotective experiment suggested that SWP-I and SWP-II possessed ROSscavenging activity. Pretreatment with these two peptides increased viability rates, suppressed SA-β-gal activities and inhibited apoptosis rates in hydrogen peroxide (H 2 O 2)-induced premature senescent 2BS cells. In conclusion, the enzymatic peptides from swim bladders of Atlantic cod (Gadus morhua) possessed antioxidant activities and could effectively protect premature cell senescence induced by H 2 O 2 .

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Effect of sulfated galactan from Porphyra haitanensis on H2O2-induced premature senescence in WI-38 cells

Cited by 30 publications

References 26 publications

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

Antioxidant, Anti-Obesity, and Anti-Aging Activities of Jeju Citrus Blended Vinegar

In vitro antioxidant and anti-aging properties of swim bladder peptides from Atlantic cod (Gadus morhua)

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