Effect of synthesis parameters of the sol–gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine

Kortesuo, Pirjo; Ahola, Manja; Kangas, Minna; Jokinen, Mika; Leino, Tiina; Vuorilehto, Lauri; Laakso, Sirpa; Kiesvaara, Juha; Yli‐Urpo, Antti; Marvola, Martti

doi:10.1016/s0142-9612(02)00016-9

Cited by 59 publications

(44 citation statements)

References 19 publications

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“…peptides, proteins) or other drugs can be also achieved through spray-drying technology associated to sol-gel polymerization process. In other words, sol-gel process is carried under soft conditions, and when combined with spray drying can deal with the production of microspheres with sensitive molecules entrapped on them [32,38]. Spray-dried silica gel microspheres are reported in the literature as a promising system to be administered in the form of a drug injectable [38,39].…”

Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

125

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Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.

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Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

125

View full text Add to dashboard Cite

show abstract

“…However, a study of the influence of the sol±gel parameters on the release rate of the spray-dried particles revealed that only limited control over the final release rate could be achieved. [30] Indeed, varying the pH of the sol±gel solution away from the isoelectric point led to burst release, due to a significant increase in the rate of matrix dissolution. Although increasing the water to alkoxide ratio successfully reduced the rate of matrix dissolution and associated drug release, this was achieved by increased coagulation of the droplets inside the spray-dryer.…”

Section: Particle Production: Using Droplets As Microreactorsmentioning

confidence: 99%

Silica Particles: A Novel Drug‐Delivery System

Barbé¹,

et al. 2004

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In recent decades, significant advances in drug‐delivery systems have enabled more effective drug administration. To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been designed. They suffer from limitations, including poor thermal and chemical stability, and rapid elimination by the immune system. In contrast, silica particles offer a biocompatible, stable, and “stealthy” alternative. Bioactive molecules can be easily encapsulated within silica particles by combining sol–gel polymerization with either spray‐drying or emulsion chemistry. Spray‐drying faces challenges, including low yield, surface segregation, and size limitations. In contrast, sol–gel emulsions enable the production of nanoparticles with homogeneous drug distribution, and permit ambient temperature processing, necessary for handling biologicals. Independent control of the size and release rate can be readily achieved. Preliminary in‐vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti‐tumor agents, show good potential for cancer treatment.

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“…The scanning electron microscopy analysis of spray dried powders showed spherical microparticles with nanoparticles on their surfaces (Müller et al, 2000;Pohlmann et al, 2002;Raffin et al, 2003). In parallel, silica nano and microparticles have been described as drug controlled release carriers prepared by sol-gel processes (Kortesuo et al, 2002;Smirnova et al, 2003), porous hollow silica nanoparticles (Chen et al, 2004) or organosilicate-polymer drug delivery systems (Cypes et al, 2003). Furthermore, silica particles have been studied for the adsolubilization of drugs and other substances on their surfaces, employing cationic or nonionic surfactants (Cherkaoui et al, 1998;Cherkaoui et al, 2000), and for development of powders for inhalation (Kawashima et al, 1998) and nanoparticles for in vitro gene transfer (Kneuer et al, 2000;Sameti et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Beck

Lionzo

Costa

et al. 2008

Braz. J. Chem. Eng.

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-This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.

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Effect of synthesis parameters of the sol–gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine

Cited by 59 publications

References 19 publications

Spray Drying: An Overview

Spray Drying: An Overview

Silica Particles: A Novel Drug‐Delivery System

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

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