Background: Stroke is a disease caused by interference with blood flow in the brain which is still a global problem today. Post-stroke care needs to be done to prevent worsening of the condition. One of the right interventions that can be done is virtual reality therapy and range of motion exercise. This study aims to examine, analyze and estimate changes in the range of motion of stroke patients with virtual reality therapy and range of motion exercise. Subjects and Method: Meta-analysis was carried out according to the PRISMA flow chart and the PICO model (Population: stroke patients, Intervention: virtual reality therapy and range of motion exercise, Comparison: not performed virtual reality therapy and range of motion exercise Outcome: range of motion). The databases used are Google Scholar, PubMed, and Science Direct. The keywords used ("virtual reality" OR VR) AND (stroke OR CVD) AND ("range of motion exercise" OR ROM OR "motor exercise") AND (stroke OR CVD) AND "Randomized Control Trial". The inclusion criteria were full text articles with RCT studies published in 2012-2022, articles in English, and bivariate and multivariate analysis. Analysis was performed using ReVman 5.3. Results: There were 20 articles with a randomized control trial design originating from Iran,