Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice

Ghaisas, Mahesh M.; Navghare, Vijay; Takawale, Abhijit; Zope, Vineet; Tanwar, M. B.; Deshpande, A. D.

doi:10.1016/j.jep.2009.01.008

Cited by 41 publications

(22 citation statements)

References 16 publications

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“…gallocatechin) [19,31]. These substances are frequently implicated in its anti-hyperglycemic effects [32][33][34][35]. Gallocatechin is one of the active constituents of Musa cavendish inner peel which increases peripheral glucose utilization [19,36].…”

Section: Discussion Blood Glucosementioning

confidence: 99%

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance.

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Section: Discussion Blood Glucosementioning

confidence: 99%

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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“…The antihyperglycemic effect of TG may be due to the chemical constituents of TG like glycosides, terpenoids, tannins, and saponins. Substances like glycosides, terpenoids, tannins and saponins are frequently implicated as having antidiabetic effects (Matsudha et al, 2002;Guy et al, 2007;Ghaisas et al, 2009) and are the major constituents of TG (Khare, 2007).…”

Section: Resultsmentioning

confidence: 99%

Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxan induced diabetic rats

Ghaisas¹,

Navghare²,

Takawale³

et al. 2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYIn India, Tectona grandis is traditionally used in the treatment of diabetes mellitus and lipid disorder. In the present study, the antihyperglycemic and lipid lowering effect of ethanolic extract of bark of Tectona grandis (TG) was evaluated using alloxan induced diabetes in rats. Alloxan was given at the dose of 140 mg/kg, i.p. After induction of diabetes, TG was administered for 42 days p. o. and simultaneously different biochemical parameters like plasma glucose, liver glycogen content, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P < 0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P < 0.01) in serum HDL-cholesterol and liver glycogen content. Treatment with TG showed significant reduction (P < 0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P < 0.01) by TG. TG treatment for 42 days showed significant decrease in serum LDL-cholesterol (P < 0.01) and significant increase in serum HDLcholesterol level (P < 0.01). Moreover, diabetic control there was significant decrease in liver glycogen content which was significantly increased (P < 0.05) by treatment with TG. Hence, from the result obtained in the present study it can be concluded that Tectona grandis has the potential to treat diabetes condition and associated lipid disorder.

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“…Marginal data have been available related with teak such as ethanolic extract of bark [32,33] and methanolic extract of root for the treatment of diabetes mellitus [34]. In spite of the above activities leaves of the plant also possess analgesic and antioxidant activity [35].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Phenolic Acids and Antioxidant Activities of Young and Mature Leaves of Tectona Grandis L F

Murukan

Murugan

2018

Asian J Pharm Clin Res

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Objective: The present study aims in comparison of phenolic acids and its antioxidant potentialities of young and mature leaf extract of Tectona grandis L f. Methods:Various phenolic acids present in methanolic leaf extract of young and mature leaves of T. grandis were analyzed by reversed-phase highperformance liquid chromatography analysis. The antioxidant potentiality of the extracts was determined by various analytical methods such as 2,2-diphenyl-1-picrylhydrazyl, ferric reducing/antioxidant power, and metal chelating activity.Results: Methanolic leaf extracts of young and mature leaf of T. grandis showed a pool of phenolic compounds such as gallic, vanillic, p-hydroxybenzoic, ferulic, chlorogenic, sinapic, p-coumarate, and cinnamic acids. Irrespective of the methods used for analyzing antioxidant capacity, young leaf extract showed potent antioxidant potentiality when compared with the mature leaf extract. Conclusion:The methanolic extract of teak leaves is rich source of many phenolic compounds, and these compounds attribute to the antioxidant capacity of the leaves. Meanwhile, by comparing the young and mature leaves, the young leaves showed much more potential than the other. It is, therefore, concluded that the young teak leaves can be used as a good source of natural antioxidant.

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Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice

Cited by 41 publications

References 16 publications

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxan induced diabetic rats

Comparison of Phenolic Acids and Antioxidant Activities of Young and Mature Leaves of Tectona Grandis L F

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