Effect of teriparatide on repair of femoral metaphyseal defect in ovariectomized rats

Tao, Zhou-Shan; Lv, Yang-Xun; Cui, Wei; Huang, Zheng-Liang; Tu, Kai-kai; Zhou, Qiang; Sun, Tao; Yang, Lei

doi:10.1007/s00391-015-0949-1

Cited by 23 publications

(18 citation statements)

References 24 publications

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“…A critical-sized bone defect is defined as an intraosseous wound that will not spontaneously heal completely without intervention, 28 the diameter of 3 mm considered as critical in animal model of OVX rat, 29 including already confirmed previous studies by our group. 19,30 The operative management of critical-size bone defects in humans is an outstanding problem in contemporary orthopedics and trauma surgery. To date, autologous bone graft is the gold standard to treat such injuries but this method is greatly restricted by important morbidities related to the bone graft collection procedure 31 and there is a crucial need for developing new bone substitutes.…”

Section: Discussionmentioning

confidence: 99%

Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats

et al. 2018

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The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defect, strontium-modified calcium phosphate cement was prepared by mixing sieved granules of calcium phosphate cement and 5% SrCO for medical use, and then strontium-modified calcium phosphate cement with dripped bone morphogenetic protein-2 solution (5 µg) was implanted into the defect of OVX rats until death at eight weeks. The defected area in distal femurs of rats was harvested for evaluation by histology, micro-CT, and biomechanics. The results of our study show that a lower single-dose local administration of bone morphogenetic protein-2 combined local usage of strontium-modified calcium phosphate cement can increase the healing of defects in OVX rats. Furthermore, treatments with single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement showed a stronger effect on accelerating the local bone formation than calcium phosphate cement and strontium-modified calcium phosphate cement used alone. The results from our study demonstrate that combination of a lower single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement had an additive effect on local bone formation in osteoporosis rats.

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Section: Discussionmentioning

confidence: 99%

Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats

et al. 2018

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“… 11 Conversely, significant reduction of sliding of lag screw, femoral shortening, varus collapse, and incidence of cut-out of the lag screw was noted in patients who received teriparatide (Table 1 ). Tao et al 33 study 27 female Sprague–Dawley rats and concluded that 8 weeks of teriparatide use provides a positive effect on repair of femoral metaphyseal defect. This positive effect provides sufficient contact between fracture fragments to decreases excessive sliding of the lag screw and prevents subsequent complications.…”

Section: Discussionmentioning

confidence: 99%

Teriparatide Improves Fracture Healing and Early Functional Recovery in Treatment of Osteoporotic Intertrochanteric Fractures

et al. 2016

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Osteoporotic intertrochanteric fractures result in serious health problems and decrease health-related quality of life (HRQoL). Faster time-to-union is important for early return to daily activities and reduction of complications. Teriparatide has been shown to accelerate fracture healing, but the literature is sparse on this topic. The aim of this study is to assess whether teriparatide accelerates fracture healing.Between 2008 and 2014, patients with osteoporotic intertrochanteric fractures who underwent surgical interventions were enrolled in this retrospective cohort study. Group 1 included patients who were not on any osteoporosis medication prior to fracture and who postoperatively received only calcium and vitamin D; patients in Group 2 were not on any osteoporosis medication prior to fracture, and received teriparatide and calcium and vitamin D postoperatively. Patients in Group 3 were those who were on alendronate prior to fracture and postfracture received teriparatide as well as calcium and vitamin D. Demographics, time-to-union, HRQoL (short-form health survey [SF]-12 physical component summary [PCS] and SF-12 mental component summary [MCS]), morbidities, mortalities, and radiographic and functional outcomes between groups were compared.A total of 189 patients were enrolled in this study. There were 83 patients in Group 1, 47 patients in Group 2, and 59 patients in Group 3. A significantly shorter time-to-union was found in the teriparatide-treated groups (mean, 13.6, 12.3, and 10.6 weeks, respectively [P = 0.002]). With regard to SF-12 PCS, the scores were significantly better in teriparatide-treated groups at 3 months (mean, 19, 28, and 29, respectively [P = 0.002]) and 6 months (mean, 28, 37, and 38, respectively [P = 0.008]). Similar inter-group differences were noted when comparing the pain scores, the ability to get around the house, the ability to get out of the house, and the ability to go shopping at 3 and 6 months. Complications and mortality were also markedly reduced in the teriparatide-treated groups.Postoperative use of teriparatide for 6 months appears to be an effective adjunct therapy in the treatment of patients with osteoporotic intertrochanteric fractures. However, because of the limited power of the study, a prospective, randomized, large-scale cohort study is still required for determining the efficacy of teriparatide.

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“…Several animal studies have shown that PTPD by dual mechanism of action, influencing both bone formation activity and bone resorption. [8,9,44,45] PTPD up-regulate gene markers associated with osteoblast differentiation and an inhibitor of the Wnt pathway. [6,46] Successful attempt to use of TPTD even after revision surgery of nonunion has been published.…”

Section: Can Tptd Be An Alternative For Nonunion?mentioning

confidence: 99%

“…Its anabolic effect is given by the stimulation of the osteoblast, and fibroblast growth factor 2 is also up-reguhttps://doi.org/10.11005/jbm.2020.27.3.167 lated in TPTD treated individuals. [8][9][10] There has been previous reviews that suggest the role of TPTD as alternate to induce fracture healing. [11][12][13] However, to date, many clinical trials have been undertaken to elucidate the efficacy of TPTD for inducing fracture healing in several situations, such as atypical femoral fracture (AFF).…”

Section: Introductionmentioning

confidence: 99%

Does Teriparatide Improve Fracture Union?: A Systematic Review

Yoon

Kim

2020

J Bone Metab

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We conducted an updated review of the evidence of teriparatide (TPTD) for fracture healing for the following questions. (1) Does it decrease fracture healing time?; (2) Can it be an alternative treatment for nonunion?; (3) Does it aid the union of atypical femoral fracture (AFF)? We searched PubMed, EMBASE, and Cochrane Library including "Fracture" AND "nonunion" AND "Teriparatide". In total, 57 publications met our inclusion criteria were summarized. This systemic review of the available literature revealed that TPTD works positively with regard to enhancing fracture healing time and union of AFF. There are also many case studies on the use of TPTD could be a potential new safe treatment for nonunion with no side effects. However, level 1 studies on the evidence of TPTD are still lacking so far. Over the last decade, a growing body of evidence has accumulated suggesting that TPTD can be an adjunct to enhance fracture healing or a therapeutic option to treat nonunion, but greater evidences from large volume prospective trials are needed.

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Effect of teriparatide on repair of femoral metaphyseal defect in ovariectomized rats

Abstract: Our findings suggest a positive effect of PTH on defect healing in ovariectomized rats.

Cited by 23 publications

References 24 publications

Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats

Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats

Teriparatide Improves Fracture Healing and Early Functional Recovery in Treatment of Osteoporotic Intertrochanteric Fractures

Does Teriparatide Improve Fracture Union?: A Systematic Review

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