Effect of testosterone supplementation on sexual functioning in aging men: a 6-month randomized controlled trial

Abstract

Serum testosterone levels decline significantly with aging and this has been associated with reduced sexual function. We have conducted a double-blind, randomized, placebo-controlled trial to investigate the effect of testosterone supplementation on sexual function in 237 elderly men with a testosterone level o13.7 nmol l À1 . Participants were randomly assigned to receive oral testosterone undecanoate or a placebo for 6 months. A total of 207 men completed the study. After treatment, there were no differences in scores on sexual function between the groups. Subanalysis showed that although a baseline testosterone level in the lowest tertile was associated with significantly lower scores for sexual fantasies, desire of sexual contact and frequency of sexual contact, supplementation of testosterone did not result in improvement on any of these items in this group. In conclusion, the findings do not support the view that testosterone undecanoate supplementation for 6 months to elderly men with low-normal testosterone concentrations favorably affects sexual function.

Testosterone Levels and Bone Mineral Density in Healthy Elderly Men

“…The results of the current study also indicate that higher values of os calcis, phalangeal QUS, and pBMD at the phalanges were observed in healthy elderly adults with higher T plasma levels. There are studies that have not found a positive association between T levels and BMD, but these do not support the data that Iucif and colleagues present, and based on the data presented, there may have been some misinterpretations.…”

Pathophysiology, evaluation and treatment of erectile dysfunction: review article

“…A utilização de reposição hormonal oral se dá principalmente pelo undecanoato de testosterona, com doses de 160 mg/dia, embora não haja relatos de que sua administração melhore a função sexual do paciente 95 . O undecanoato de testosterona também foi administrado via intramuscular tendo melhora parcial em alguns estudos e nenhuma melhora em outros [96][97][98][99] . A administração de dehidroepiandrosterona (DHEA) 50 mg, 2 vezes ao dia, pode ser feita, contudo não há estudos que documentem sua eficácia.…”

Sexual dysfunction in the older man

“…Sexual dysfunction in LOH includes not only low libido and ED, but also decreased penile sensation and difficulty attaining orgasm. 9,10,21,22 Biochemical diagnosis of LOH Men with symptoms suspicious for LOH should undergo assessment of serum T levels. A serum sample for total T should be obtained between 07.00 and 11.00 h, to exclude falsely low T levels due to diurnal variations.…”

“…In absence of clinical response, therapy should be discontinued and further investigations should be carried out to identify other potential causes of symptoms. 9,[22][23][24] Testosterone supplementation. T should preferably be administered in its natural form.…”