Effect of the Addition of Antimicrobial Agents on Shore A Hardness and Roughness of Soft Lining Materials

Abstract

The smallest changes of hardness and roughness with time in the modified groups compared to controls were observed for itraconazole groups for both materials.

Surface Properties of Temporary Soft Liners Modified by Minimum Inhibitory Concentrations of Antifungals

“…The test was performed at a constant load of 10 N/s, and the results were obtained in Shore A units on a scale from 0 to 100 (14). Five measurements were carried out with a 6 mm distance between them (14) and the mean was obtained for each specimen at each evaluation period.…”

“…Then, another glass slab was placed over each filled mold and maintained under digital pressure until final plastification, as recommended by the manufacturer. After this, the specimens were separated from the molds and the edges were carefully smoothed with a scalpel (14). Specimens were then individually immersed in 17.5 mL of distilled water at 37 °C (MA 0324; Marconi Equipamentos para Laboratórios Ltda., Piracicaba, SP, Brazil) for 24 h, 7 days or 14 days (12,24) prior to the hardness/roughness measurements.…”

“…Because the temporary soft lining material's life cycle is approximately 14 days, the treatment period of denture-induced stomatitis using these drug-modified materials is similar to the period required for conventional topical antifungal agents (10). However, it has been shown that the incorporation of drugs at commercially available concentrations in soft liners may affect its morphological structure (11) and properties such as tensile strength (9,12), water sorption (13), modulus of elasticity, and weight (9), hardness (9,14) and roughness (14). In the search for antifungal concentrations compatible with the properties of these materials, Bueno et al (15) determined the minimum inhibitory concentrations (MICs) for C. albicans biofilm of antifungal agents (nystatin, miconazole, ketoconazole, itraconazole and chlorhexidine) incorporated in temporary resilient liners (Trusoft and Softone).…”

Effect of different beverages on the hardness and surface roughness of soft denture lining materials

“…Most of them were conducted on color changes, surface roughness and bonding properties to denture bases. [11][12][13][14][15][16] However, only two study was carried out on the effect of beverages on the hardness of the soft denture lining material and in that research Safari et al 17 report that the hardness of the temporary acrylic soft lining materials more increased in water than alcohol and cola after 12 day immersion period. Stored in liquid media increased the hardness is in accordance with our research.…”

Efeito da incorporação de agentes antimicrobianos sobre propriedades físicas de materiais resilientes temporários para base de prótese

“…Apesar das vantagens terapêuticas apresentadas pelos fármacos adicionados em concentrações comercialmente disponíveis aos materiais resilientes temporários modificados, tem sido demonstrado que modificação por adição de fármacos pode afetar suas caraterísticas estruturais (ADDY, M;URBAN et al, 2009), módulo de elasticidade e peso (ADDY, M; HANDLEY, R, 1981) além de outras propriedades como resistência à tração (SCHNEID, 1992;URBAN et al, 2006), dureza SCHNEID, 1992;URBAN et al, 2013) rugosidade superficial e resistência da união ao descolamento da resina acrílica para base de prótese (ALCANTARA et al, 2012) O objetivo do estudo de foi determinar, em laboratório, concentrações inferiores às utilizadas pelos estudos supracitados para os fármacos incorporados a materiais resilientes temporários, de forma a se atingir uma efetiva inibição fúngica sem causar efeitos indesejados às propriedades da matriz polimérica modificada. Assim, determinaram as mínimas concentrações inibitórias (MCIs) de biofilme de C. albicans para cinco agentes antifúngicos/antimicrobianos incorporados a um condicionador tecidual (Softone) e um reembasador temporário (Trusoft).…”