Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride‐induced hepatotoxicity in rats

Moresco, Rafael Noal; Sperotto, Rita Leal; Bernardi, Anie Schiavo; Cardoso, Ricardo França; Gomes, Patrícia Bezerra

doi:10.1002/ptr.2158

Cited by 28 publications

(30 citation statements)

References 8 publications

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“…The main compounds present in the ASc (gallic acid, chlorogenic acid and rutin) can be responsible for these effects, since they have been known by their antioxidant capacity. The protection effect of ASc observed in the present study is consistent with the beneficial results found by Stanley [75], Moresco [76] and Bopp [44].…”

Section: Discussionsupporting

confidence: 82%

Syzygium cumini Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

Bona

Bellé

Sari

et al. 2010

Cell Physiol Biochem

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Diabetes mellitus, a chronic metabolic disorder, has assumed epidemic proportions and its long-term complications can have devastating consequences. The oxidative stress in diabetes was greatly increased due to prolonged exposure to hyperglycemia and impairment of oxidant/antioxidant equilibrium. Syzygium cumini is being widely used to treat diabetes by the traditional practitioners over many centuries. Adenosine deaminase (ADA) and 5′-Nucleotidase (5′NT) are enzymes of purine nucleoside metabolism that play an important role in the regulation of adenosine (Ado) levels. In this study, we investigated the effect of Syzygium cumini aqueous leaves extract (ASc) on ADA and 5′NT activities and on parameters of oxidative stress under in vitro conditions, using platelets of patients with Type 2 diabetes mellitus. Platelet-Rich Plasma (PRP) was assayed by ADA, 5′NT, Catalase (CAT), Superoxide Dismutase (SOD) activities and Thiobarbituric acid reactive substances (TBARS) levels. We observed that ADA, 5′NT activities and TBARS levels were significantly higher when compared to the control group, and ASc (100 and 200 µg/mL) prevented these effects. Our study demonstrates that ASc was able to remove oxidant species generated in diabetic conditions and modulates in the Ado levels. Then, ASc may promote a compensatory response in platelet function, improving the susceptibility-induced by the diabetes mellitus.

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Section: Discussionsupporting

confidence: 82%

Syzygium cumini Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

Bona

Bellé

Sari

et al. 2010

Cell Physiol Biochem

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“…66 The fruit extract of Jamun has also been reported to protect rat hepatocytes against carbon tetrachloride-induced toxicity in vitro. 30 Similarly, the administration of ethanol extract of Jamun fruit pulp for 8 consecutive days prior to paracetamol treatment has been shown to protect rats against paracetamol-induced hepatotoxicity.…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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“…It has several medicinal properties. 5 The phenolic content of S. cumini leaves and antioxident activity were found high and the latter was comparable to ascorbic acid. 6 The presence of polyphenolic compounds in ethanolic leaf extract of S. cumini might be responsible for its high antioxidant activity.…”

Section: Introductionmentioning

confidence: 90%

Leaf Extract of Syzygium cumini Shows Anti-Vibrio Activity Involving DNA Damage

Ahsan

Paul

Islam

et al. 2012

Dhaka Univ. J. Pharm. Sci

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ABSTRACT:The aim of the study was to investigate the effect of an ethanol extract of leaf (EEL) of Syzygium cumini against Vibrio cholerae serogroups Ogawa and Inaba. The antimicrobial activity of EEL was evaluated by the disc diffusion method against multi-drug resistant Ogawa and Inaba. The EEL effectively inhibited the growth of both serogroups. This growth inhibition was accompanied by fragmentation of genomic DNA as revealed by agarose gel electrophoresis. This result suggested that the EEL might inhibit bacterial growth involving DNA damage either through activation of signal transduction pathways or through direct interaction of the metabolites present in the EEL with DNA. Therefore, EEL of S. cumini has potential growth inhibitory activity against multi drug resistant Vibrios. This inhibitory effect of EEL might be explored to develop effective candidate(s) to combat cholera.

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Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride‐induced hepatotoxicity in rats

Cited by 28 publications

References 8 publications

<i>Syzygium cumini</i> Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

<i>Syzygium cumini</i> Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Leaf Extract of Syzygium cumini Shows Anti-Vibrio Activity Involving DNA Damage

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