Effect of the metal nature on hemostatic activity of water-soluble gold and silver nanocomposites

Абзаева, К. А.; Zhilitskaya, L. V.; Belozerskaya, G.G.; Ostrovskaya, L. A.

doi:10.1007/s11172-017-2021-3

Cited by 12 publications

(1 citation statement)

References 16 publications

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“…Известно, что полиакрилат золота, будучи эффективным гемостатиком, обладает высокой специфичностью взаимодействия с молекулой альбумина, образуя при этом интерполимерный комплекс [21]. Можно полагать, что и в организме животных-опухоленосителей аурумакрил после поступления в кровяное русло связывается с альбуминами сыворотки крови и в виде комплекса с альбумином попадает в ткани органов и опухоли, где происходит дальнейшее взаимодействие этого комплекса с внутриклеточными макромолекулами.…”

Section: обсуждение результатовunclassified

Aurum Polyacrylate: The Experimental Study of the Antitumor Activity

Островская¹,

Корман²,

Блюхтерова³

et al. 2020

Rossijskij bioterapevtičeskij žurnal

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Introduction. The investigation of metal substituted organic compounds as potential antitumor drugs is one of the promising areas of research in experimental and clinical oncology.Objective. The pre-clinical study of the original antitumor drug aurum polyacrylate (aurumacryl) which belongs to such new for oncology group of compounds as polyacrylates of metals was the aim of this work.Materials and methods. Aurumacryl antitumor activity was determined as the tumor growth inhibitory effect against some of the murine solid tumors (Lewis lung carcinoma, Acatol adenocarcinoma and Ca-755 adenocarcinoma). Drug cytotoxic effect against some of the human tumor cells (Mel-Mo melanoma, A549 lung carcinoma, MCF-7 breast carcinoma, HCT116 colon adenocarcinoma) was evaluated with standard МТТ-test. The aurumacryl pharmacokinetics in tumor bearing mice (Lewis lung carcinoma) was studied. The inductively coupled plasma mass spectrometry method was used for the estimation of the aurum maintenance in the tested tissues (tumor, blood, kidneys, liver, lungs, spleen, brain).Results. The 80–90 % tumor growth inhibitory effect of aurumacryl against some solid tumors in mice had been revealed in vivo as well as the death of the 60–90 % human tumor cells of various origins in vitro. Beside this the strong decrease of the number of proliferating MCF-7 tumor cells had been shown. The distribution of aurumacryl in the body of the mice with the solid tumor had been revealed.Conclusion. On the base of the data obtained the further study of the aurumacryl as a potential antitumor agent seems rather promising.

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Section: обсуждение результатовunclassified