Effect of The Obesity Index on Plasma Taurine Levels in Korean Female Adolescents

Lee, Mi Young; Cheong, Sun Hee; Chang, Kyung Ja; Choi, Mi Ja; Kim, Soon Ki

doi:10.1007/978-1-4615-0077-3_36

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…Our findings suggest that reduced taurine concentrations could be linked also to increased adiposity in dogs, alternatively that lean dogs require less taurine and subsequently excrete more. A connection between taurine deficiency and overweight as suggested by our results, is well in line with findings in a number of studies in humans and rodents [ 35 , 36 ]. In humans, urinary taurine excretion has been negatively associated with body mass index [ 37 ] and in rodent models of obesity, a lower concentration of urinary taurine has been found in obese individuals [ 38 – 40 ].…”

Section: Discussionsupporting

confidence: 93%

The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge

Söder¹,

Hagman²,

Dicksved³

et al. 2017

PLoS ONE

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Obesity in dogs is an increasing problem and better knowledge of the metabolism of overweight dogs is needed. Identification of molecular changes related to overweight may lead to new methods to improve obesity prevention and treatment. The aim of the study was firstly to investigate whether Nuclear Magnetic Resonance (NMR) based metabolomics could be used to differentiate postprandial from fasting urine in dogs, and secondly to investigate whether metabolite profiles differ between lean and overweight dogs in fasting and postprandial urine, respectively. Twenty-eight healthy intact male Labrador Retrievers were included, 12 of which were classified as lean (body condition score (BCS) 4–5 on a 9-point scale) and 16 as overweight (BCS 6–8). After overnight fasting, a voided morning urine sample was collected. Dogs were then fed a high-fat mixed meal and postprandial urine was collected after 3 hours. Metabolic profiles were generated using NMR and 45 metabolites identified from the spectral data were evaluated using multivariate data analysis. The results revealed that fasting and postprandial urine differed in relative metabolite concentration (partial least-squares discriminant analysis (PLS-DA) 1 comp: R2Y = 0.4, Q2Y = 0.32; cross-validated ANOVA: P = 0.00006). Univariate analyses of discriminant metabolites showed that taurine and citrate concentrations were elevated in postprandial urine, while allantoin concentration had decreased. Interestingly, lean and overweight dogs differed in terms of relative metabolite concentrations in postprandial urine (PLS-DA 1 comp: R2Y = 0.5, Q2Y = 0.36, cross-validated ANOVA: P = 0.005) but not in fasting urine. Overweight dogs had lower postprandial taurine and a trend of higher allantoin concentrations compared with lean dogs. These findings demonstrate that metabolomics can differentiate 3-hour postprandial urine from fasting urine in dogs, and that postprandial urine metabolites may be more useful than fasting metabolites for identification of metabolic alterations linked to overweight. The lowered urinary taurine concentration in overweight dogs could indicate alterations in lipid metabolism and merits further investigation.

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Section: Discussionsupporting

confidence: 93%

The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge

Söder¹,

Hagman²,

Dicksved³

et al. 2017

PLoS ONE

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“…Plasma taurine levels were significantly lower (41%) in obese subjects as compared with nonobese subjects [15]. Similarly, in a study comprising obese, normal, and underweight Korean adolescent females, plasma taurine levels were lowest in obese subgroup [26]. Lower levels of plasma taurine have also been noted in patients with diabetes [16].…”

Section: Taurine Levels Of the Body In Obesitymentioning

confidence: 83%

“…Several studies showed that plasma taurine levels are lower in obese subjects and animals as compared with their nonobese counterparts. Blood taurine levels decreased in high‐fat diet‐induced obese mice.…”

Section: Taurine and Adipose Tissuesmentioning

confidence: 99%

Role of taurine in the pathogenesis of obesity

Murakami

2015

Molecular Nutrition Food Res

131

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Taurine is a sulfur-containing amino acid that is present in mammalian tissues in millimolar concentrations. Taurine is involved in a diverse array of biological and physiological functions, including bile salt conjugation, osmoregulation, membrane stabilization, calcium modulation, anti-oxidation, and immunomodulation. The prevalence of obesity and being overweight continues to rise worldwide at an alarming rate. Obesity is associated with a higher risk of metabolic and cardiovascular diseases, cancer, and other clinical conditions. Ingestion of taurine has been shown to alleviate metabolic diseases such as hyperlipidemia, diabetes, hypertension, and obesity in animal models. A global epidemiological survey showed that 24-h urinary taurine excretion, as a marker of dietary taurine intake, was inversely associated with BMI, blood pressure, and plasma cholesterol in humans. In addition, taurine chloramine, an endogenous product derived from activated neutrophils, has been reported to suppress obesity-induced oxidative stress and inflammation in adipocytes. Synthetic activity and concentration of taurine in adipose tissues and plasma have been shown to decrease in humans and animals during the development of obesity, suggesting a relationship between taurine deficiency and obesity. In this review, I summarize the effects of taurine on the progression of obesity in animal models and humans. Furthermore, I discuss possible mechanisms underlying the antiobesity effects of taurine.

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“…Among the various beneficial effects of taurine [ 8 , 9 ], the anti-obesity effect has been analyzed in clinical studies [ 10 , 11 , 12 ] as well as in animal models [ 13 , 14 , 15 , 16 ]. Many studies have indicated that taurine deficiency is associated with metabolic dysfunction, such as obesity or diabetes [ 17 , 18 ], and its supplementation may help slow down the progression of obesity.…”

Section: Introductionmentioning

confidence: 99%

Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model

Kim

Doss

Kim

et al. 2020

Foods

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This study was conducted to investigate if taurine supplementation stimulates the induction of thermogenic genes in fat tissues and muscles and decipher the mechanism by which taurine exerts its anti-obesity effect in a mildly obese ICR (CD-1®) mouse model. Three groups of ICR mice were fed a normal chow diet, a high-fat diet (HFD), or HFD supplemented with 2% taurine in drinking water for 28 weeks. The expression profiles of various genes were analyzed by real time PCR in interscapular brown adipose tissue (BAT), inguinal white adipose tissue (iWAT), and the quadriceps muscles of the experimental groups. Genes that are known to regulate thermogenesis like PGC-1α, UCP-1, Cox7a1, Cox8b, CIDE-A, and β1-, β2-, and β3-adrenergic receptors (β-ARs) were found to be differentially expressed in the three tissues. These genes were expressed at a very low level in iWAT as compared to BAT and muscle. Whereas, HFD increased the expression of these genes. Taurine supplementation stimulated the expression of UCP-1, Cox7a1, and Cox8b in BAT and only Cox7a1 in muscle, while there was a decrease in iWAT. In contrast, fat deposition-related genes, monoamine oxidases (MAO)-A, and -B, and lipin-1, were decreased by taurine supplementation only in iWAT and not in BAT or muscle. In conclusion, the potential anti-obesity effects of taurine may be partly due to upregulated thermogenesis in BAT, energy metabolism of muscle, and downregulated fat deposition in iWAT.

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Effect of The Obesity Index on Plasma Taurine Levels in Korean Female Adolescents

Cited by 11 publications

References 5 publications

The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge

The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge

Role of taurine in the pathogenesis of obesity

Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model

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