Effect of the quaternary ammonium compound trospium chloride on 24 hour jejunal motility in healthy subjects.

Schmidt, Thomas; Widmer, R; Pfeiffer, A.; Kaess, H

doi:10.1136/gut.35.1.27

Cited by 26 publications

(30 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the interdigestive period there were three quantitative parameters that were significantly different between the patient group and the healthy controls: in dyspeptics the incidence of antral or jejunal phase 3s was reduced and the relative contribution of phase 2 to the MMC cycle was increased. These observations confirm previous findings,6 7 and the reference values obtained in the healthy volunteers are in accordance with other studies using ambulatory manometry 2425 Phase 3 has been interpreted as having a housekeeper function by causing rapid aboral and effective propagation of intraluminal contents 19.…”

Section: Discussionsupporting

confidence: 92%

Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms, and gastric emptying

Wilmer¹,

Cutsem²,

Andrioli³

et al. 1998

Gut

View full text Add to dashboard Cite

Background-Previousstudies have failed to identify manometric patterns of gastrointestinal motor activity that can distinguish dyspepsia from health. Aims-To test the hypothesis that the combined use of prolonged, ambulatory, antrojejunal manometry and computer aided analysis in patients selected for the severity of their symptoms could reveal new insights into gastrointestinal motor activity in patients with severe motilitylike dyspesia Methods-Twenty four hour antrojejunal ambulatory manometry was performed in 14 patients and 10 healthy volunteers. Parameters characterising digestive and fasted motility were obtained by a validated computer program and visual analysis. Scoring systems quantified the degree of dysmotility as well as the severity of symptoms. Gastric emptying times were measured in each patient. Results-There was a high prevalence of antral and jejunal dysmotility both during the interdigestive period (71% of patients) and in the postprandial period (78%). During the interdigestive period there was a reduced incidence of antral and jejunal phases, a larger contribution of phase 2 during migrating motor complex cycles, and aberrant configuration of jejunal phase 3 in 29% of patients. Postprandially, the most frequent finding was antral (29% of patients) or jejunal (29%) hypomotility or hypermotility. Minute rhythm was present both during the postprandial (29% of patients) and the interdigestive period (21%). There was no positive correlation between symptom scores, gastric half emptying times, or motility scores. Conclusion-Even with the use of prolonged recordings and advanced computer aided analysis, it is not possible to identify a specific motor pattern which can discriminate patients with severe motility-like dyspepsia from those with other diseases or even healthy individuals. Clinical symptoms or gastric half emptying times are poor predictors of gastrointestinal dysmotility in patients with functional dyspepsia. (Gut 1998;42:235-242)

show abstract

Section: Discussionsupporting

confidence: 92%

Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms, and gastric emptying

Wilmer¹,

Cutsem²,

Andrioli³

et al. 1998

Gut

View full text Add to dashboard Cite

show abstract

“…The chemical structures of oxybutynin, tolterodine, and trospium chloride are depicted in Figure 1 [6,7]. The major difference between tertiary and quaternary amines is the (+) charge and hydrophilic nature of trospium chloride, a quaternary amine.…”

Section: Chemical Structure: Tertiary Versus Quaternary Aminesmentioning

confidence: 99%

Trospium chloride: A quaternary amine with unique pharmacologic properties

Pak¹,

Petrou

Staskin³

2003

Curr Urol Rep

View full text Add to dashboard Cite

The mainstay of pharmacologic treatment of overactive bladder is anticholinergic therapy. Cholinergic blockade is efficacious in decreasing the symptoms of urgency, frequency, and urge incontinence, but also is associated with undesirable side effects such as dry mouth, blurred vision, constipation, and central nervous system side effects. The property of anticholinergic agents that has been associated with increased efficacy and tolerability is receptor specificity. The safety of anticholinergic agents has been associated with the pharmacokinetics, metabolism, protein binding, and ability to penetrate the blood brain barrier. Trospium chloride, available in Europe for more than 20 years and under review by the US Food and Drug Administration for the treatment of overactive bladder, is a quaternary amine that is minimally metabolized, not highly protein-bound, and theoretically should not cross the blood brain barrier. Some of the characteristics of this unique anticholinergic agent are reviewed in this article and the relative contributions of these factors are discussed.

show abstract

“…Intubation of the small intestine was performed as described in detail previously [5]. Briefly, after an overnight fast, the subjects were intubated transnasally with the MII manometry system after local anesthesia of nose and throat (Xylocaine Spray; Astra Chemicals, Wedel/Holstein, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…Manometry has established as a tool in clinical practice to test the integrity of the neuromuscular apparatus of the small intestine [2,3,4,5]. However, manometric studies do not provide information on the transport processes in the intestinal lumen.…”

Section: Introductionmentioning

confidence: 99%

Multiple Intraluminal Impedance Measurement and Manometry in the Jejunum of Healthy Subjects: A New Tool for Diagnosis of Small Bowel Motility

Seidl

Gundling²,

Pehl³

et al. 2010

Digestion

View full text Add to dashboard Cite

Background: The relationships between contractile activity and transport of intraluminal contents in the human small intestine are not well understood. Aim: To study both phenomena by combined measurements of intraluminal impedance and pressurein the jejunum of healthy subjects. Methods: 12 healthy volunteers (m 4, f 8), mean age 32.3 years (24–49 years), underwent jejunal combined impedance/manometry recordings (six channels at 2-cm intervals). Fasting (one MMC cycle) and postprandial motility were recorded. Results: Intestinal transport differed with the phases of motility. No transport was seen in phase I, regular bolus transport occurred during phase III. The longest duration of transport was observed in late phase II preceding phase III. Irregular and intermittent bolus transport occurred during early phase II and in the postprandial period. Three types of relationship between contractions and bolus transport were identified: transport with single contractions or migrating clustered contractions and transport without contractile activity. The frequency of these events differed with the direction of bolus transport, and a relationship between propagation velocity and bolus presence time was established. Conclusion: Combined simultaneous measurement of intraluminal impedance and manometry is a promising new method to elucidate the relationships between bolus transport and contractile activity in the human small bowel.

show abstract

Effect of the quaternary ammonium compound trospium chloride on 24 hour jejunal motility in healthy subjects.

Cited by 26 publications

References 24 publications

Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms, and gastric emptying

Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms, and gastric emptying

Trospium chloride: A quaternary amine with unique pharmacologic properties

Multiple Intraluminal Impedance Measurement and Manometry in the Jejunum of Healthy Subjects: A New Tool for Diagnosis of Small Bowel Motility

Contact Info

Product

Resources

About