Effect of thiabendazole and fenbendazole on glucose uptake and carbohydrate metabolism in trichuris globulosa

Jasra, Nisha; Sanyal, Sankar Nath; Khera, S.

doi:10.1016/0304-4017(90)90055-g

Cited by 22 publications

(24 citation statements)

References 15 publications

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“…For example, benzimidazoles have been shown to inhibit amino peptidase activity and glutamate catabolism, reduce glucose uptake, increase intracellular calcium levels, and inhibit microtubule formation. [14][15][16] Here we demonstrate that flubendazole displays antileukemia and antimyeloma activity in vitro and in vivo at pharmacologically achievable concentrations. Mechanistically, flubendazole alters tubulin structure and function by interacting with a site on tubulin distinct from Vinca alkaloid microtubule inhibitors.…”

Section: Introductionmentioning

confidence: 99%

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

Spagnuolo

Hurren

et al. 2010

Blood

124

128

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Section: Introductionmentioning

confidence: 99%

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

Spagnuolo

Hurren

et al. 2010

Blood

124

128

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“…Similar inhibitory effect of A. sativum on the LDH activity catalysing both the oxidation and reduction reactions in H. contortus has been reported by Veerakumari and Lakshmi [45]. The inhibition of lactate dehydrogenase might arrest the carbon influx in the glycolytic pathway and the generation of the necessary energy through oxidative phosphorylation [36]. Consequently, production of malate, which serves as main substrate for mitochondrial phosphorylation is reduced, which leads to reduced production of ATP [39].…”

Section: Resultsmentioning

confidence: 66%

“…Consequently, the energy yielding process is impaired and deprives the parasite of its ATP production. Decreased generation of ATP proves fatal to the parasites [36].The inhibition of PK and PEPCK activities treated with anthelmintics has been observed in other helminths [37,38,39]. Also, Navaneetha Lakshmi and Veerakumari [40] reported the inhibitory effect on the PK and PEPCK activities in Haemonchus contortus treated with Allium sativum.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Studies on the Effect of Ethanol Extract of Syzygium Aromaticum on the Carbohydrate Metabolism of Cotylophoron Cotylophorum

Dhanraj¹,

Veerakumari²

2015

IJAVST

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Paramphistomosis is one of the major pathogenic diseases in domestic animals and responsible for heavy economic loss in terms of reduced milk, meat and wool production. Cotylophoron cotylophorum is more prevalent in Tamilnadu. In the present investigation, the effect of Syzygium aromaticum ethanol extract on the enzymes of carbohydrate metabolism viz. pyruvate kinase, phosphoenolpyruvate carboxykinase, lactate dehydrogenase, malate dehydrogenase, fumarate reductase and succinate dehydrogenase of Cotylophoron cotylophorum was studied in vitro. The parasites were incubated in five different sub-lethal concentrations of ethanol extract of Syzygium aromaticum viz. 0.005, 0.01, 0.05, 0.1 and 0.5mg/ml for 2, 4 and 8 h. The activity of the enzymes was assayed using standard procedures. The enzyme activity was expressed in terms of protein. The data obtained were analyzed statistically. Ethanol extract of Syzygium aromaticum significantly inhibited the enzymes of carbohydrate metabolism and the percentage of inhibition was dose and time dependent. Inhibition of these enzymes leads to decreased ATP production which may be fatal to the parasites. The present study validates the anthelmintic property of ethanol extract of Syzygium aromaticum against C. cotylophorum.

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“…In addition, antihelminthic activity of Lawsonia may be due to its effect on inhibition of glucose uptake in the parasites and depletion of its glycogen synthesis (Bairagi et al 2011), a mechanism which is similar to that of flubendazole which inhibits cytoplasmic microtubules in the intestinal or absorptive cells of the worms, thus inhibiting glucose uptake and glycogen storage depletion, leading to death of the worms within days (Jasra et al 1990). However, Lawsonia has the additional advantage of being natural product with minimal side effects.…”

Section: Discussionmentioning

confidence: 99%

Comparison between the effect of Lawsonia inermis and flubendazole on Strongyloides species using scanning electron microscopy

et al. 2014

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Strongyloides species is a helminth of worldwide distribution primarily in tropical and subtropical regions. It is the only soil-transmitted helminth with the ability for autoinfection so; it may lead to severe systemic manifestations especially in immunosuppressed patients. Chemotherapy is currently considered the best therapeutic option for strongyloidiasis but some drugs are expensive and others have side effects as nausea, diarrhea and headache. Strongyloides larva is resistant to most chemical agents so, search for plant extracts may provide other effective but less expensive treatment. Lawsonia inermis Linn, popularly known as Henna, has been proven to have antihelminthic, antibacterial and antifungal properties. The current study was carried out to evaluate the efficacy of Lawsonia inermis on Strongyloides spp. In vitro using scanning electron microscopy. Fifty Strongyloides species. larvae and free living females were incubated with different concentrations of Lawsonia (1, 10, 100 mg/ml), for different incubation periods (24, 48, 72 and 96 h) in comparison to the same concentrations of flubendazole at the same different time points. The results showed that Lawsonia inermis in a concentration of 10 mg/ml incubated with Strongyloides spp. female for 24 h affected the parasite cuticular surface in the form of transverse and longitudinal fissures and transverse depression in comparison to no cuticular change with flubendazole (100 mg/ml). This suggests that Lawsonia inermis may be a promising phytotherapeutic agent for strongyloidiasis.

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Effect of thiabendazole and fenbendazole on glucose uptake and carbohydrate metabolism in trichuris globulosa

Cited by 22 publications

References 15 publications

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

In Vitro Studies on the Effect of Ethanol Extract of Syzygium Aromaticum on the Carbohydrate Metabolism of Cotylophoron Cotylophorum

Comparison between the effect of Lawsonia inermis and flubendazole on Strongyloides species using scanning electron microscopy

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