Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus

Hosseinzadeh, Hossein; Parvardeh, Siavash; Nassiri‐Asl, Marjan; Sadeghnia, Hamid Reza; Ziaee, Toktam

doi:10.1016/j.phymed.2006.12.005

Cited by 235 publications

(173 citation statements)

References 37 publications

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“…However, the exact mechanism is not yet clear. [18] In our experimental study, renal ischemia for 45 min followed by reperfusion for 45 min caused significant renal dysfunction as assessed by a marked increase in the serum concentrations of urea and creatinine in the control group. We also evaluated NS treatment to decrease the I/R-induced elevations of TOS, OSI, and MPO levels, and NS also increased TAC and CAT levels in the renal tissue supernatants.…”

Section: Discussionmentioning

confidence: 65%

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

et al. 2010

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Section: Discussionmentioning

confidence: 65%

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

et al. 2010

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“…N. sativa plant is one of the most extensively studied, both phytochemically and pharmacologically. The extracts of N. sativa seeds have been used by patients to suppress coughs disintegrate renal calculi, retard the carcinogenic process (Worthen et al, 1998;Hosseinzadeh et al, 2007) treat abdominal pain, diarrhea, flatulence and polio (Enomoto et al, 2001), exert choleretic and uricosuric activities, antiinflammatory (Chakravarty, 1993;Houghton et al, 1995) and antioxidant effects (Mansour et al, 2002;Mansour, 2000). Besides, the essential oil was shown to have antihelminthic (Agarwal et al, 1979), antinematodal (Akhtar and Riffat, 1991), antischistosomal (Mahmoud et al, 2002), antimicrobial (Aboul-Ela et al, 1996;Hanafy and Hatem, 1991;Aboul-Ela, 2002) and antiviral (Salem and Hossain, 2000) effects.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Al-Haj¹,

Shamsudin²,

Alipiah³

et al. 2010

American Journal of Pharmacology and Toxicology

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Problem statement: Seeds of Nigella sativa L., commonly known as black seed, have been used in traditional medicine by many Asian, Middle Eastern and Far Eastern Countries to treat headache, coughs, abdominal pain, diarrhea, asthma, rheumatism and other diseases. The seeds of this plant are the most extensively studied, both phytochemically and pharmacologically. The aqueous and oil extracts of the seeds have been shown to possess especially nowadays in pharmaceutical antioxidant, anti-inflammatory, anticancer, analgesic, antimicrobial activities and medicinal and cosmetic applications, sanitary, cosmetic, agricultural and food industries. Approach: The aim of this study was to formulate a new delivery system for dermal and cosmetic application by the incorporation of Nigella sativa essential oil into solid lipid nanoparticles SLN. SLN formulations were prepared following the high-pressure homogenization after starring and ultra-trax homognization techniques using hydrogenated palm oil Softisan 154 and N. sativa essential oil as lipid matrix, sorbitol and water as surfactants. The SLN formulation particle size was determined using Photon Correlation System (PCS). Results: The change of particle charge was studied by Zeta Potential (ZP) measurements, while the melting and re-crystallization behavior was studied using Differential Scanning Calorimetry (DSC). Data showed a high physical stability for both formulations at various storage temperatures during 3 months of storage. In particular, average diameter of N. sativa essential oilloaded SLN did not vary during storage and increased slightly after freeze-drying the SLN dispersions. Conclusion: Therefore, obtained results showed that the studied SLN formulations are suitable carriers in pharmaceutical and cosmetic fields.

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“…[24] It is reported that the volatile components of NS such as thymoquinone decreases lipid peroxidation through suppression of reactive oxygen and nitrogen species formation and increases antioxidant defense system activity. [25,26] NS extracts have bronchodilatator, antibacterial, hypotensive, antidiabetic, gastro-protective, hepatoprotective, antihistaminic, anti-oxidative and neuroprotective effects. [27][28][29][30] The present study was carried out to investigate the antioxidant and protective effects of NS against oxidative stress and neuronal damage induced by FA administration on the frontal lobe of the rat brain, using histological, immunohistochemical and biochemical methods.…”

mentioning

confidence: 99%

Nigella sativa protects against formaldehyde-induced neurotoxicity in the rat frontal cortex

Mohamad¹,

Essa²,

Ata³

2015

Anatomy

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Formaldehyde (FA) is a compound commonly used in industry and medicine that can react with different macromolecules such as proteins, nucleic acids and low molecular weight substances as amino acids. [1,2] In particular, anatomists and medical students are exposed to FA gas during cadaver dissections. [3,4] Humans are exposed to FA from direct environmental sources like paint, plywood, cosmetics, cigarette smoke, photochemical smog and even various fruits as well as from the metabolism of xenobiotics. [5,6] FA is accepted as toxic over certain doses and its at high room temperatures its harmful effects increase due to volatility. [7][8][9][10] Physiological FA forms by the metabolism of L-methionine, histamine or methylamine in the body, and contribute to biological methylation by folic acid. [11] Acute exposure to FA causes central nervous system symptoms such as headache, malaise, insomnia, anorexia

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Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus

Cited by 235 publications

References 37 publications

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

Protective Effects of Nigella sativa against Ischemia-Reperfusion Injury of Kidneys

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Nigella sativa protects against formaldehyde-induced neurotoxicity in the rat frontal cortex

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