Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

Harada, Naoaki; Okajima, Kenji; Narimatsu, Noriko; Kurihara, Hiroki; Nakagata, Naomi

doi:10.1016/j.ghir.2008.01.005

Cited by 43 publications

(24 citation statements)

References 38 publications

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“…In conclusion, our data in this study provide evidence that Asc 2‐P treatment increases IGF‐1 secretion from DP cells, promotes proliferation of follicular keratinocytes and stimulates human hair follicle growth in vitro . Our data are in line with the very recent finding that raspberry ketone increases IGF‐1 production, thereby promoting hair growth 22 . These data, together with the correlation of the expression of IGF‐1 in follicular DP with the therapeutic efficacy of finasteride in androgenetic alopecia, 23 point to the feasibility of treatment and prevention of hair loss by means of triggering the expression of IGF‐1 via PI3K signalling in DP cells.…”

Section: Discussionsupporting

confidence: 89%

l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

Kwack

Shin

Kim

et al. 2009

British Journal of Dermatology

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Section: Discussionsupporting

confidence: 89%

l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

Kwack

Shin

Kim

et al. 2009

British Journal of Dermatology

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“…The MXD and CO groups showed a significantly higher IGF-1 mRNA expression, as compared to the SA group. The result is consistent with recent reports that IGF-1 mRNA expression was increased in the region promoting hair growth (21) and, in the absence of IGF-1 protein, organ-cultured human HF undergoes a transformation reminiscent of the events at the beginning of the catagen phase characterized by the lack of cells proliferation (22). In particular, the CO group showed a higher expression than the MXD group during the experimental period.…”

Section: Discussionsupporting

confidence: 92%

Action Mechanism of Chamaecyparis obtusa Oil on Hair Growth

Park¹,

Kim²,

Kim³

2013

Toxicological Research

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This study was carried out to examine the action mechanism of Chamaecyparis obtusa oil (CO) on hair growth in C57BL/6 mice. For alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GT) activities in the skin tissue, at week 4, the 3% minoxidil (MXD) and 3% CO treatment groups showed an ALP activity that was significantly higher by 85% (p < 0.001) and 48% (p < 0.05) and an γ-GT activity that was significantly higher by 294% (p < 0.01) and 254% (p < 0.05) respectively, as compared to the saline (SA) treatment group. For insulin-like growth factor-1 (IGF-1) mRNA expression in the skin tissue, at week 4, the MXD and CO groups showed a significantly higher expression by 204% (p < 0.05) and 426% (p < 0.01) respectively, as compared to the SA group. At week 4, vascular endothelial growth factor (VEGF) expression in the MXD and CO groups showed a significantly higher expression by 74% and 96% (p < 0.05) respectively, however, epidermal growth factor (EGF) expression in the MXD and CO groups showed a significantly lower expression by 66% and 61% (p < 0.05) respectively, as compared to the SA group. Stem cell factor (SCF) expression in the MXD and CO groups was observed by immunohistochemistry as significant in a part of the bulge around the hair follicle and in a part of the basal layer of the epidermis. Taking all the results together, on the basis of effects on ALP and γ-GT activity, and the expression of IGF-1, VEGF and SCF, which are related to the promotion of hair growth, it can be concluded that CO induced a proliferation and division of hair follicle cells and maintained the anagen phase. Because EGF expression was decreased significantly, CO could delay the transition to the catagen phase.

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“…Capsaicin is commonly applied topically to reduce aches and burning feelings, the frequently reported symptoms of painful neuropathy (14). It is currently used in topical creams and high‐dose dermal patches to relieve the pain of peripheral neuropathies such as postherpetic neuralgia caused by shingles, and can be directly applied to abdominal skin with no side effects in animal models and humans (15,16).…”

Section: Introductionmentioning

confidence: 99%

Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high‐fat diet‐induced obese mice

Lee

Shin

Yoon

et al. 2013

Obesity

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Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

Cited by 43 publications

References 38 publications

l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

Action Mechanism of Chamaecyparis obtusa Oil on Hair Growth

Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high‐fat diet‐induced obese mice

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