Effect of topical ketanserin administration on intraocular pressure.

Abstract

The effect of topical ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes was evaluated. The study was performed on 10 healthy volunteers and 10 glaucomatous patients. Systolic arterial blood pressure (SBP), diastolic arterial blood pressure (DBP), heart rate (HR), IOP, tonographic outflow facility, pupil diameter, corneal thickness, and tear secretion were recorded at baseline and at 1 hour intervals for 12 hours after topical administration of 0-5% ketanserin or placebo, given in a randomised, double masked, crossover fashion. The alternative treatment was given 1 week later. In ali subjects ketanserin significantly lowered IOP, while no variations in SBP, DBP, HR, pupil diameter, corneal thickness, and tear secretion were found. When subjects received placebo no significant variations of lOP occurred. Total outflow facility, measured by conventional tonography, increased significantly after drug administration in all subjects. Ketanserin is effective up to 6 hours in control subjects and 9 hours in glaucomatous patients. The placebo did not induce any change in this component of the aqueous humour dynamic in normal or in glaucomatous eyes. The findings indicate that topical ketanserin might be added to the list of antiglaucomatous agents. (BrJ Ophthalmol 1993; 77: 344-348) Eye Clinic,

Intraocular pressure in schizophrenic patients treated with psychiatric medications

“…Some studies have shown acute angle closure glaucoma and IOP raise in patients using SSRI drugs, possibly due to 5-HT action (9)(10)(11) . 5-HT receptors have already been demostraded in the human eye (12)(13)(14) . Tryciclic antidepressants due to their anticholinergic proprieties can also lead to acute angle closure glaucoma or worsen primary open-angle glaucoma because of their potential of causing mydriasis (15)(16) .…”

Effect of Ketanserin Administration on Intraocular Pressure

“…Costagliola et al [3, 4, 5]reported that oral and topical ketanserin administration significantly reduced intraocular pressure (IOP) both in healthy volunteers and glaucomatous patients by increasing the total outflow facility and by reducing the outflow resistance. In experimental models ketanserin has been shown to reduce ocular pressure when applied topically [6, 7, 8].…”

Color Doppler Imaging of Ocular Blood Flow after Topical Ketanserin

“…We may think that serotonin causes an increase in permeability of the vessels mediated by S 2 receptors and that ketanserin antagonizes these receptors and reduces the aqueous secretion. Moreover, we may suppose that ketanserin lowers the intraocular pressure aqueous outflow [9]through the secondary outflow pathways: choroidal vessels and vorticose vein.…”

“…The topical application of ketanserin 0.5%, an antagonist of 5-HT 2 serotoninergic receptors, induced a decrease in intraocular pressure both in normal and glaucomatous eyes [7, 9]. …”

“…This substance was found in the ciliary body and abundantly in the aqueous humor of both experimental animals and humans [5, 6]. Oral and topical administration of this drug lowers intraocular pressure in males [7, 8, 9]. …”